Geris Liesbet

Département d'aérospatiale et mécanique > Génie biomécanique

GIGA In silico medecine - Biomechanics Research Unit

See author's contact details
ORCID
0000-0002-8180-1445
Main Referenced Co-authors
Van Oosterwyck, Hans (85)
Vander Sloten, Jos (60)
Papantoniou, Ioannis (39)
Schrooten, Jan (39)
Carlier, Aurélie  (25)
Main Referenced Keywords
Animals (26); Humans (22); Computer Simulation (18); tissue engineering (14); Models, Biological (12);
Main Referenced Unit & Research Centers
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE] (8)
Biomechanics Research Unit, ULiège and Prometheus, KU Leuven (3)
Biomechanics Research Unit (2)
GIGA In silico medecine-Biomechanics Research Unit - ULiège [BE] (2)
Prometheus, the KU Leuven R&D Division of Skeletal Tissue Engineering (http://www.kuleuven.be/prometheus) (2)
Main Referenced Disciplines
Engineering, computing & technology: Multidisciplinary, general & others (269)
Biochemistry, biophysics & molecular biology (73)
Mechanical engineering (50)
Microbiology (33)
Computer science (18)

Publications (total 397)

The most downloaded
3740 downloads
Van schepdael, Carlier, A., & Geris, L. (2016). Sensitivity analysis by design of experiments. In L. Geris & D. Gomez-Cabrero (Eds.), Uncertainty in Biology: a computational modeling approach (pp. 327-366). Springer. https://hdl.handle.net/2268/225469

The most cited

296 citations (Scopus®)

Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., Gilbert, A., Fernandes, J. F., Bukhari, H. A., Wajdan, A., Martinez, M. V., Santos, M. S., Shamohammdi, M., Luo, H., Westphal, P., Leeson, P., DiAchille, P., Gurev, V., Mayr, M., ... Lamata, P. (21 December 2020). The 'Digital Twin' to enable the vision of precision cardiology. European Heart Journal, 41 (48), 4556-4564. doi:10.1093/eurheartj/ehaa159 https://hdl.handle.net/2268/292771

Books and journal issues published as editor or director

Geris, L., & Gomez-Cabrero, D. (Eds.). (2015). Uncertainty in biology: a computational modeling approach. Springer.

Geris, L. (Ed.). (2013). Computational modeling in tissue engineering. (1). Springer.

Book chapters or contributions to a collective book as author or co-author

Papantoniou, I., Lambrechts, T., Gupta, P., de Bournonville, S., Loverdou, N., Geris, L., & Aerts, J. (2022). Bioreactor Sensing and Monitoring for Cell Therapy Manufacturing. In: Bioreactors for Stem Cell Expansion and Differentiation. In Bioreactors for Stem Cell Expansion and Differentiation. CRC Press.
Peer reviewed

Reina-Romo, E., Papantoniou, I., Bloemen, V., & Geris, L. (2019). 4 - Computational design of tissue engineering scaffolds. In M. Mozafari, F. Sefat, ... A. Atala (Eds.), Woodhead Publishing Series in Biomaterials. Woodhead Publishing. doi:10.1016/B978-0-08-102563-5.00004-6
Peer reviewed

Geris, L. (2017). Utopie voor morgen: digitale gezondheidszorg. In B. Pattyn & d'Hoine, Lessen voor de eenentwintigste eeuw. Leuven University Press.
Peer reviewed

Van schepdael, Carlier, A., & Geris, L. (2016). Sensitivity analysis by design of experiments. In L. Geris & D. Gomez-Cabrero (Eds.), Uncertainty in Biology: a computational modeling approach (pp. 327-366). Springer.
Peer reviewed

Geris, L., & Van Hoyweghen, I. (2016). Digital Health Care for Real Patients. In V. Achten, G. Bouckaert, ... E. Schokkaert (Eds.), A Truly Golden Handbook’: The Scholarly Quest for Utopia. University Press Leuven.
Peer reviewed

papantoniou, I., mantalaris, A., sonnaert, M., lambrechts, T., aerts, J.-M., Geris, L., & schrooten, J. (2015). Product and Process Design: Toward Industrial TE Manufacturing. In C. Van Blitterswijk (Ed.), Tissue Engineering. Elsevier.
Peer reviewed

van oosterwyck, H., Geris, L., & Garcia-Aznar, J.-M. (2015). Cell Mechanics and Mechanobiology. In M. Doblare & J. Merodio, Component Encyclopedia of PHYSICAL SCIENCES, ENGINEERING AND TECHNOLOGY RESOURCES, Biomechanics (pp. 271-300). United Kingdom: Eolss Publishers/UNESCO.
Peer reviewed

Geris, L., & Gomez-Cabrero, D. (2015). An introduction to uncertainty in the development of computational models of biological processes. In Modeling under uncertainty: a computational modeling approach. Springer.
Peer reviewed

Gomez-Cabrero, D., Tegner, J., & Geris, L. (2015). Computational modeling under uncertainty: challenges and opportunities. In Modeling under uncertainty: a computational modeling approach. Springer.
Peer reviewed

Carlier, A., Van Oosterwyck, H., & Geris, L. (2014). In silico biology of bone regeneration inside calcium phosphate scaffolds. In Tissue Engineering: Computer Modeling, Biofabrication and Cell Behavior. Netherlands: Springer.
Peer reviewed

Geris, L. (2013). In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering. In Computational modeling in tissue engineering. Springer.
Peer reviewed

Hulsman, M., Geris, L., & Reinders, M. (2013). Computational analysis of high-throughput material screens. In J. de Boer & C. Van Blitterswijck (Eds.), Materiomics: high-throughput screening of biomaterial properties. Cambridge University Press.
Peer reviewed

Geris, L., & Gerisch, A. (2011). Mathematical modeling of cell-cell and cell-matrix adhesion in tissue engineering using continuum models. In A. Geffen (Ed.), Cellular and Biomolecular Mechanics and Mechanobiology (1st, pp. 431-450). Springer-Verlag.

Gerisch, A., & Geris, L. (2007). A Finite Volume Spatial Discretisation for taxis-diffusion-reaction systems with axi-symmetry: application to fracture healing. In A. Deutsch, L. Brusch, H. Byrne, G. de Vries, ... H. Herzel (Eds.), Advances in Mathematical Modeling of Biological Systems (pp. 303-316). Boston, United States - Massachusetts: Birkhäuser.

Gerisch, A., Geris, L., Van Oosterwyck, H., Vander Sloten, J., & Weiner, R. (2005). Reliable and efficient numerical simulation of a model of tissue differentiation in a bone chamber model. In G. Bischoff (Ed.), Micro- and Nanostructures of Biological Systems (pp. 60-76).

Geris, L., Van Oosterwyck, H., Duyck, J., Naert, I., & Vander Sloten, J. (2005). Mechanobiology of bone regeneration and bone adaptation to achieve stable long-term fixation of endosseous implants. In M. E. Zeman & M. Cerrolaza (Eds.), Computational Modeling of Tissue Surgery (pp. 2-37). Southampton, United Kingdom: WITPress.

Duyck, J., Geris, L., Van Oosterwyck, H., Vander Sloten, J., & Naert, I. (2005). Kanttekeningen bij immediate belasting van orale implantaten. In C. de Baat, J. K. N. Aps, W. G. Brands, C. E. L. Carels, R. Jacobs, R. Kooke, ... W. van Welsenes (Eds.), Het Tandheelkundig jaar 2006 (pp. 132-145). Netherlands: Bohn Stafleu van Loghum.

Articles accepted in reviewed journal

Salar Amoli, M., Anand, R., EzEldeen, M., Geris, L., Jacobs, R., & Bloemen, V. (12 February 2024). Development of 3D Printed pNIPAM-Chitosan Scaffolds for Dentoalveolar Tissue Engineering. Gels (Basel, Switzerland), 10 (2). doi:10.3390/gels10020140
Peer reviewed

Decoene, I., Nasello, G., Madeiro de Costa, R. F., Nilsson Hall, G., Pastore, A., Van Hoven, I., Ribeiro Viseu, S., Verfaillie, C., Geris, L., Luyten, F. P., & Papantoniou, I. (2024). Robotics-Driven Manufacturing of Cartilaginous Microtissues for Skeletal Tissue Engineering Applications. Stem Cells Translational Medicine. doi:10.1093/stcltm/szad091
Peer Reviewed verified by ORBi

Liang, B., Sadeghian Dehkord, E., Van hede, D., Barzegari, M., Verlee, B., Pirson, J., Nolens, G., Lambert, F., & Geris, L. (03 December 2023). Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds. Journal of Functional Biomaterials, 14 (563), 22. doi:10.3390/jfb14120563
Peer Reviewed verified by ORBi

Ansoms, P., Barzegari, M., Vander Sloten, J., & Geris, L. (November 2023). Coupling biomechanical models of implants with biodegradation models: A case study for biodegradable mandibular bone fixation plates. Journal of the Mechanical Behavior of Biomedical Materials, 147, 106120. doi:10.1016/j.jmbbm.2023.106120
Peer Reviewed verified by ORBi

Crump, K. B.* , Alminnawi, A.* , Bermudez-Lekerika, P., Compte, R., Gualdi, F., McSweeney, T., Muñoz-Moya, E., Nüesch, A., Geris, L., Dudli, S., Karppinen, J., Noailly, J., Le Maitre, C., & Gantenbein, B. (2023). Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research. JOR Spine. doi:10.1002/jsp2.1294
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Viceconti, M., De Vos, M., Mellone, S., & Geris, L. (11 October 2023). Position paper From the digital twins in healthcare to the Virtual Human Twin: a moon-shot project for digital health research. IEEE Journal of Biomedical and Health Informatics, PP. doi:10.1109/JBHI.2023.3323688
Peer Reviewed verified by ORBi

Bouakaz, I., Sadeghian Dehkord, E., Meille, S., Schrijnemakers, A., Boschini, F., Preux, N., Hocquet, S., Geris, L., Nolens, G., Grossin, D., & Dupret-Bories, A. (2023). 3D printed triply periodic minimal surfaces calcium phosphate bone substitute: The effect of porosity design on mechanical properties. Ceramics International. doi:10.1016/j.ceramint.2023.10.238
Peer Reviewed verified by ORBi

Sadeghian Dehkord, E., Kerckhofs, G., Compère, P., Lambert, F., & Geris, L. (22 July 2023). An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation. Journal of Functional Biomaterials, 14 (7), 388. doi:10.3390/jfb14070388
Peer Reviewed verified by ORBi

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (July 2023). A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics. Computational and Structural Biotechnology Journal, 21, 3768-3795. doi:10.1016/j.csbj.2023.07.016
Peer Reviewed verified by ORBi

Stein, M., Elefteriou, F., Busse, B., Fiedler, I. A., Kwon, R. Y., Farrell, E., Ahmad, M., Ignatius, A., Grover, L., Geris, L., & Tuckermann, J. (2023). Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society. Journal of Bone and Mineral Research. doi:10.1002/jbmr.4868
Peer Reviewed verified by ORBi

Sremački, I., Asadian, M., De Geyter, N., Leys, C., Geris, L., & Nikiforov, A. (08 May 2023). Potentials of a Plasma-Aerosol System for Wound Healing Advanced by Drug Introduction: An In Vitro Study. ACS Biomaterial Science and Engineering, 9 (5), 2392 - 2407. doi:10.1021/acsbiomaterials.2c01391
Peer Reviewed verified by ORBi

Joiret, M., Leclercq, M., Lambrechts, G., Rapino, F., Close, P., Louppe, G., & Geris, L. (06 April 2023). Cracking the genetic code with neural networks. Frontiers in Artificial Intelligence, 6. doi:10.3389/frai.2023.1128153
Peer Reviewed verified by ORBi

Borgiani, E., Nasello, G., Ory, L., Herpelinck, T., GROENEVELDT, L., Bucher, C. H., Schmidt-Bleek, K., & Geris, L. (2023). COMMBINI: an experimentally-informed COmputational Model of Macrophage dynamics in the Bone INjury Immunoresponse. Frontiers in Immunology, 14, 1231329. doi:10.3389/fimmu.2023.1231329
Peer Reviewed verified by ORBi

Lesage, R., Van Oudheusden, M., Schievano, S., Van Hoyweghen, I., Geris, L., & Capelli, C. (2023). Mapping the use of computational modelling and simulation in clinics: A survey. Frontiers in Medical Technology, 5, 1125524. doi:10.3389/fmedt.2023.1125524
Peer reviewed

Schamberger, B., Roschger, A., Ziege, R., Anselme, K., Amar, M. B., Bykowski, M., Castro, A. P. G., Cipitria, A., Coles, R., Dimova, R., Eder, M., Ehrig, S., Escudero, L. M., Evans, M. E., Fernandes, P. R., Fratzl, P., Geris, L., Gierlinger, N., Hannezo, E., ... Dunlop, J. W. C. (2022). Curvature in Biological Systems: Its quantification, Emergence and Implications Across the Scales. Advanced Materials, 2206110. doi:10.1002/adma.202206110
Peer reviewed

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J. V. M., & Geris, L. (09 November 2022). An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. BMC Biology, 20 (1), 253. doi:10.1186/s12915-022-01451-8
Peer Reviewed verified by ORBi

Kanapeckaitė, A., Mažeikienė, A., Geris, L., Burokienė, N., Cottrell, G. S., & Widera, D. (November 2022). Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crises. Biophysical Chemistry, 290, 106891. doi:10.1016/j.bpc.2022.106891
Peer Reviewed verified by ORBi

Pappalardo, F., Wilkinson, J., Busquet, F., Bril, A., Palmer, M., Walker, B., Curreli, C., Russo, G., Marchal, T., Toschi, E., Alessandrello, R., Costignola, V., Klingmann, I., Contin, M., Staumont, B., Woiczinski, M., Kaddick, C., Salvatore, V. D., Aldieri, A., ... Viceconti, M. (November 2022). Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices. IEEE Journal of Biomedical and Health Informatics, 26 (11), 5282-5286. doi:10.1109/JBHI.2022.3198145
Peer Reviewed verified by ORBi

Hall, G. N., Chandrakar, A., Pastore, A., Ioannidis, K., Moisley, K., Cirstea, M., Geris, L., Moroni, L., Luyten, F. P., Wieringa, P., & Papantoniou, I. (2022). Engineering bone-forming biohybrid sheets through the integration of melt electrowritten membranes and cartilaginous microspheroids. Acta Biomaterialia. doi:10.1016/j.actbio.2022.10.037
Peer Reviewed verified by ORBi

Salar Amoli, M., Anand, R., EzEldeen, M., Amorim, P. A., Geris, L., Jacobs, R., & Bloemen, V. (01 August 2022). The development of a 3D printable chitosan-based copolymer with tunable properties for dentoalveolar regeneration. Carbohydrate Polymers, 289, 119441. doi:10.1016/j.carbpol.2022.119441
Peer Reviewed verified by ORBi

Corradi, M. P. F., de Haan, A. M., Staumont, B., Piersma, A. H., Geris, L., Pieters, R. H. H., Krul, C. A. M., & Teunis, M. A. T. (August 2022). Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies. Biomaterials and Biosystems, 7, 100061. doi:10.1016/j.bbiosy.2022.100061
Peer Reviewed verified by ORBi

Anand, R., Salar Amoli, M., Huysecom, A.-S., Amorim, P. A., Agten, H., Geris, L., & Bloemen, V. (24 June 2022). A tunable gelatin-hyaluronan dialdehyde/methacryloyl gelatin interpenetrating polymer network hydrogel for additive tissue manufacturing. Biomedical Materials, 17 (4), 045027. doi:10.1088/1748-605X/ac78b8
Peer Reviewed verified by ORBi

Barzegari, M., & Geris, L. (14 June 2022). BioDeg: A finite element software for the simulation ofthe corrosion and biodegradation process in metallicbiomaterials. Journal of Open Source Software, 7 (74), 4281. doi:10.21105/joss.04281
Peer Reviewed verified by ORBi

Bekisz, S., Baudin, L., Buntinx, F., Noël, A., & Geris, L. (16 March 2022). In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies. Cancers, 14 (6), 1525. doi:10.3390/cancers14061525
Peer Reviewed verified by ORBi

Barzegari, M., & Geris, L. (March 2022). Highly scalable numerical simulation of coupled reaction–Diffusion systems with moving interfaces. International Journal of High Performance Computing Applications, 36 (2), 198 - 213. doi:10.1177/10943420211045939
Peer Reviewed verified by ORBi

Sermeus, Y., Vangheel, J., Geris, L., Smeets, B., & Tylzanowski, P. (26 January 2022). Mechanical Regulation of Limb Bud Formation. Cells, 11 (3). doi:10.3390/cells11030420
Peer Reviewed verified by ORBi

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (13 January 2022). Ribosome exit tunnel electrostatics. Physical Review. E, 105 (1), 014409-1 - 014409-43. doi:10.1103/PhysRevE.105.014409
Peer Reviewed verified by ORBi

Bermudez-Lekerika, P., Crump, K. B., Tseranidou, S., Nüesch, A., Kanelis, E., Alminnawi, A., Baumgartner, L., Muñoz-Moya, E., Compte, R., Gualdi, F., Alexopoulos, L. G., Geris, L., Wuertz-Kozak, K., Le Maitre, C. L., Noailly, J., & Gantenbein, B. (2022). Immuno-Modulatory Effects of Intervertebral Disc Cells. Frontiers in Cell and Developmental Biology, 10, 924692. doi:10.3389/fcell.2022.924692
Peer Reviewed verified by ORBi

Van hede, D., Liang, B., Anania, S., Barzegari, M., Verlée, B., Nolens, G., Pirson, J., Geris, L., & LAMBERT, F. (2022). 3D-Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo. Advanced Functional Materials. doi:10.1002/adfm.202105002
Peer Reviewed verified by ORBi

Perez-Boerema, F., Barzegari, M., & Geris, L. (2022). A flexible and easy-to-use open-source tool for designing functionally graded 3D porous structures. Virtual and Physical Prototyping, 17 (3), 682 - 699. doi:10.1080/17452759.2022.2048956
Peer Reviewed verified by ORBi

Lammens, J., Maréchal, M., Delport, H., Geris, L., & Luyten, F. P. (2022). A Flowchart for the Translational Research of CellBased Therapy in the Treatment of Long Bone Defects. Journal of Regenerative Medicine, 10 (1).
Peer reviewed

Loverdou, N., Cuvelier, M., Nilsson Hall, G., Christiaens, A.-S., Decoene, I., Bernaerts, K., Smeets, B., Ramon, H., Luyten, F. P., Geris, L., & Papantoniou, I. (2022). Stirred culture of cartilaginous microtissues promotes chondrogenic hypertrophy through exposure to intermittent shear stress. Bioengineering and Translational Medicine. doi:10.1002/btm2.10468
Peer Reviewed verified by ORBi

Elahi, S. A., Tanska, P., Mukherjee, S., Korhonen, R. K., Geris, L., Jonkers, I., & Famaey, N. (December 2021). Guide to mechanical characterization of articular cartilage and hydrogel constructs based on a systematic in silico parameter sensitivity analysis. Journal of the Mechanical Behavior of Biomedical Materials, 124, 104795. doi:10.1016/j.jmbbm.2021.104795
Peer Reviewed verified by ORBi

Farzin, A., Hassan, S., Teixeira, L. S. M., Gurian, M., Crispim, J. F., Manhas, V., Carlier, A., Bae, H., Geris, L., Noshadi, I., Shin, S. R., & Leijten, J. (14 October 2021). Self-Oxygenation of Tissues Orchestrates Full-Thickness Vascularization of Living Implants. Advanced Functional Materials, 31 (42). doi:10.1002/adfm.202100850
Peer Reviewed verified by ORBi

Viceconti, M., Emili, L., Afshari, P., Courcelles, E., Curreli, C., Famaey, N., Geris, L., Horner, M., Jori, M. C., Kulesza, A., Loewe, A., Neidlin, M., Reiterer, M., Rousseau, C. F., Russo, G., Sonntag, S. J., Voisin, E. M., & Pappalardo, F. (October 2021). Possible Contexts of Use for In Silico Trials Methodologies: A Consensus-Based Review. IEEE Journal of Biomedical and Health Informatics, 25 (10), 3977-3982. doi:10.1109/JBHI.2021.3090469
Peer Reviewed verified by ORBi

Tam, W. L., Freitas Mendes, L., Chen, X., Lesage, R., Van Hoven, I., Leysen, E., Kerckhofs, G., Bosmans, K., Chai, Y. C., Yamashita, A., Tsumaki, N., Geris, L., Roberts, S. J., & Luyten, F. P. (25 September 2021). Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects. Stem Cell Research and Therapy, 12 (1), 513. doi:10.1186/s13287-021-02580-7
Peer Reviewed verified by ORBi

Nilsson Hall, G., Rutten, I., Lammertyn, J., Eberhardt, J., Geris, L., Luyten, F. P., & Papantoniou, I. (21 September 2021). Cartilaginous spheroid-assembly design considerations for endochondral ossification: towards robotic-driven biomanufacturing. Biofabrication, 13 (4). doi:10.1088/1758-5090/ac2208
Peer reviewed

Barzegari, M., Mei, D., Lamaka, S. V., & Geris, L. (September 2021). Computational modeling of degradation process of biodegradable magnesium biomaterials. Corrosion Science, 190, 109674. doi:10.1016/j.corsci.2021.109674
Peer Reviewed verified by ORBi

Musuamba, F. T., Skottheim Rusten, I., Lesage, R., Russo, G., Bursi, R., Emili, L., Wangorsch, G., Manolis, E., Karlsson, K. E., Kulesza, A., Courcelles, E., Boissel, J.-P., Rousseau, C. F., Voisin, E. M., Alessandrello, R., Curado, N., Dall'ara, E., Rodriguez, B., Pappalardo, F., & Geris, L. (August 2021). Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility. CPT: Pharmacometrics and Systems Pharmacology, 10 (8), 804-825. doi:10.1002/psp4.12669
Peer Reviewed verified by ORBi

Vinken, M., Benfenati, E., Busquet, F., Castell, J., Clevert, D.-A., de Kok, T. M., Dirven, H., Fritsche, E., Geris, L., Gozalbes, R., Hartung, T., Jennen, D., Jover, R., Kandarova, H., Kramer, N., Krul, C., Luechtefeld, T., Masereeuw, R., Roggen, E., ... Piersma, A. H. (30 June 2021). Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology, 458, 152846. doi:10.1016/j.tox.2021.152846
Peer Reviewed verified by ORBi

Barzegari, M., & Geris, L. (27 June 2021). An open source crash course on parameter estimation of computational models using a Bayesian optimization approach. Journal of Open Source Education, 4 (40), 89. doi:10.21105/jose.00089
Peer reviewed

Hall, G. N., Tam, W. L., Andrikopoulos, K. S., Casas-Fraile, L., Voyiatzis, G. A., Geris, L., Luyten, F. P., & Papantoniou, I. (June 2021). Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo. Biomaterials, 273, 120820. doi:10.1016/j.biomaterials.2021.120820
Peer Reviewed verified by ORBi

de Bournonville, S., Geris, L., & Kerckhofs, G. (02 February 2021). Micro computed tomography with and without contrast enhancement for the characterization of microcarriers in dry and wet state. Scientific Reports, 11 (1), 2819. doi:10.1038/s41598-021-81998-8
Peer Reviewed verified by ORBi

Gorgun, C., Ceresa, D., Lesage, R., Villa, F., Reverberi, D., Balbi, C., Santamaria, S., Cortese, K., Malatesta, P., Geris, L., Quarto, R., & Tasso, R. (February 2021). Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs). Biomaterials, 269, 120633. doi:10.1016/j.biomaterials.2020.120633
Peer Reviewed verified by ORBi

Papantoniou, I., Nilsson Hall, G., Loverdou, N., Lesage, R., Herpelinck, T., Mendes, L., & Geris, L. (February 2021). Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering. Advanced Drug Delivery Reviews, 169, 22-39. doi:10.1016/j.addr.2020.11.012
Peer Reviewed verified by ORBi

Van de Velde, M., Ebroin, M., Durré, T., Joiret, M., Gillot, L., Blacher, S., Geris, L., Kridelka, F., & Noël, A. (2021). Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6. Cancer Letters, 497, 154-164. doi:10.1016/j.canlet.2020.10.020
Peer Reviewed verified by ORBi

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Reina Romo, E.* , Mandal, S.* , Amorim, P., Bloemen, V., Ferraris, E., & Geris, L. (2021). Towards the Experimentally-Informed In Silico Nozzle Design Optimization for Extrusion-Based Bioprinting of Shear-Thinning Hydrogels. Frontiers in Bioengineering and Biotechnology, 9, 701778. doi:10.3389/fbioe.2021.701778
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Lafuente-Gracia, L., Borgiani, E., Nasello, G., & Geris, L. (2021). Towards in silico Models of the Inflammatory Response in Bone Fracture Healing. Frontiers in Bioengineering and Biotechnology, 9, 703725. doi:10.3389/fbioe.2021.703725
Peer Reviewed verified by ORBi

Gallez, A., Blacher, S., Maquoi, E., Konradowski, E., Joiret, M., Primac, I., Gérard, C., Taziaux, M., Houtman, R., Geris, L., Lenfant, F., Marangoni, E., Sounni, N. E., Foidart, J.-M., Noël, A., & Pequeux, C. (2021). Estetrol combined to progestogen for menopause or contraception indication is neutral on breast cancer. Cancers. doi:10.3390/cancers13102486
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Khurana, S., Schivo, S., Plass, J. R. M., Mersinis, N., Scholma, J., Kerkhofs, J., Zhong, L., van de Pol, J., Langerak, R., Geris, L., Karperien, M., & Post, J. N. (2021). An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation. Frontiers in Bioengineering and Biotechnology, 9, 732917. doi:10.3389/fbioe.2021.732917
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Corral-Acero, J., Margara, F., Marciniak, M., Rodero, C., Loncaric, F., Feng, Y., Gilbert, A., Fernandes, J. F., Bukhari, H. A., Wajdan, A., Martinez, M. V., Santos, M. S., Shamohammdi, M., Luo, H., Westphal, P., Leeson, P., DiAchille, P., Gurev, V., Mayr, M., ... Lamata, P. (21 December 2020). The 'Digital Twin' to enable the vision of precision cardiology. European Heart Journal, 41 (48), 4556-4564. doi:10.1093/eurheartj/ehaa159
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Bekisz, S., & Geris, L. (October 2020). Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications. Journal of Computational Science, 46 (101198). doi:10.1016/j.jocs.2020.101198
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Lammens, J., Maréchal, M., Delport, H., Geris, L., Oppermann, H., Vukicevic, S., & Luyten, F. P. (September 2020). A cell-based combination product for the repair of large bone defects. BONE, 138, 115511. doi:10.1016/j.bone.2020.115511
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Musuamba, F. T., Bursi, R., Manolis, E., Karlsson, K., Kulesza, A., Courcelles, E., Boissel, J.-P., Lesage, R., Crozatier, C., Voisin, E. M., Rousseau, C. F., Marchal, T., Alessandrello, R., & Geris, L. (April 2020). Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges. CPT: Pharmacometrics and Systems Pharmacology, 9 (4), 195-197. doi:10.1002/psp4.12504
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Schivo, S., Khurana, S., Govindaraj, K., Scholma, J., Kerkhofs, J., Zhong, L., Huang, X., van de Pol, J., Langerak, R., van Wijnen, A. J., Geris, L., Karperien, M., & Post, J. N. (April 2020). ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cellular Signalling, 68, 109471. doi:10.1016/j.cellsig.2019.109471
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Bolander, J., Herpelinck, T., Chaklader, M., Gklava, C., Geris, L., & Luyten, F. P. (March 2020). Single-cell characterization and metabolic profiling of in vitro cultured human skeletal progenitors with enhanced in vivo bone forming capacity. Stem Cells Translational Medicine, 9 (3), 389-402. doi:10.1002/sctm.19-0151
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Kamperman, T., Teixeira, L. M., Salehi, S. S., Kerckhofs, G., Guyot, Y., Geven, M., Geris, L., Grijpma, D., Blanquer, S., & Leijten, J. (07 February 2020). Engineering 3D parallelized microfluidic droplet generators with equal flow profiles by computational fluid dynamics and stereolithographic printing. Lab on a Chip, 20 (3), 490-495. doi:10.1039/c9lc00980a
Peer reviewed

Mehrian, M., Lambrechts, T., Papantoniou, I., & Geris, L. (2020). Computational Modeling of Human Mesenchymal Stromal Cell Proliferation and Extra-Cellular Matrix Production in 3D Porous Scaffolds in a Perfusion Bioreactor: The Effect of Growth Factors. Frontiers in Bioengineering and Biotechnology, 8, 376. doi:10.3389/fbioe.2020.00376
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Groeneveldt, L. C., Herpelinck, T., Maréchal, M., Politis, C., van IJcken, W. F. J., Huylebroeck, D., Geris, L., Mulugeta, E., & Luyten, F. P. (2020). The Bone-Forming Properties of Periosteum-Derived Cells Differ Between Harvest Sites. Frontiers in Cell and Developmental Biology, 8, 554984. doi:10.3389/fcell.2020.554984
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Mehrian, M., & Geris, L. (2020). Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms. Computer Methods in Biomechanics and Biomedical Engineering, 23 (7), 285-294. doi:10.1080/10255842.2020.1719081
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Zappia, J., Joiret, M., Sanchez, C., Lambert, C., Geris, L., Muller, M., & Henrotin, Y. (2020). From translation to protein degradation as mechanisms for regulating biological functions: A review on the SLRP family in skeletal tissues. Biomolecules, 10, 80. doi:10.3390/biom10010080
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Mukherjee, S., Nazemi, M., Jonkers, I., & Geris, L. (2020). Use of Computational Modeling to Study Joint Degeneration: A Review. Frontiers in Bioengineering and Biotechnology, 8, 93. doi:10.3389/fbioe.2020.00093
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Nilsson Hall, G., Mendes, L. F., Gklava, C., Geris, L., Luyten, F. P., & Papantoniou, I. (2020). Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing. Advanced Science, 7 (2), 1902295. doi:10.1002/advs.201902295
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Mehrian, M., Lambrechts, T., Marechal, M., Luyten, F. P., Papantoniou, I., & Geris, L. (2020). Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning. Cytotherapy, 22 (2), 82-90. doi:10.1016/j.jcyt.2019.12.006
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van Gastel, N., Stegen, S., Eelen, G., Schoors, S., Carlier, A., Daniëls, V. W., Baryawno, N., Przybylski, D., Depypere, M., Stiers, P.-J., Lambrechts, D., Van Looveren, R., Torrekens, S., Sharda, A., Agostinis, P., Lambrechts, D., Maes, F., Swinnen, J. V., Geris, L., ... Carmeliet, G. (2020). Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature, 579 (7797), 111-117. doi:10.1038/s41586-020-2050-1
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Van Sint Jan, S., & Geris, L. (December 2019). Modelling towards a more holistic medicine: The Virtual Physiological Human (VPH). Morphologie, 103 (343), 127-130. doi:10.1016/j.morpho.2019.10.044
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Grivas, K. N., Vavva, M. G., Polyzos, D., Carlier, A., Geris, L., Van Oosterwyck, H., & Fotiadis, D. I. (February 2019). Effect of ultrasound on bone fracture healing: A computational mechanobioregulatory model. Journal of the Acoustical Society of America, 145 (2), 1048. doi:10.1121/1.5089221
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de Bournonville, S., Lambrechts, T., Vanhulst, J., Luyten, F. P., Papantoniou, I., & Geris, L. (2019). Towards Self-Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture. Biotechnology Journal, 1800545. doi:10.1002/biot.201800545
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Gupta, P., Hall, G. N., Geris, L., Luyten, F. P., & Papantoniou, I. (2019). Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture. Stem Cells Translational Medicine. doi:10.1002/sctm.18-0216
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Verbeeck, L., Geris, L., Tylzanowski, P., & Luyten, F. P. (2019). Uncoupling of in-vitro identity of embryonic limb derived skeletal progenitors and their in-vivo bone forming potential. Scientific Reports, 9 (1). doi:10.1038/s41598-019-42259-x
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Brekelmans, C., Hollants, S., De Groote, C., Sohier, N., Marechal, M., Geris, L., Luyten, F. P., Ginckels, L., Sciot, R., de Ravel, T., De Smet, L., Lammens, J., Legius, E., & Brems, H. (2019). Neurofibromatosis type 1-related pseudarthrosis: Beyond the pseudarthrosis site. Human Mutation. doi:10.1002/humu.23783
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Geris, L., & Papantoniou, I. (2019). The Third Era of Tissue Engineering: Reversing the Innovation Drivers. Tissue Engineering. Part A, 25 (11-12), 821-826. doi:10.1089/ten.TEA.2019.0064
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Geris, L., Lambrechts, T., Carlier, A., & Papantoniou, I. (June 2018). The future is digital: In silico tissue engineering. Current Opinion in Biomedical Engineering, 6, 92-98. doi:10.1016/j.cobme.2018.04.001
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Hoekstra, A. G., Bavel, E. V., Siebes, M., Gijsen, F., & Geris, L. (2018). Virtual physiological human 2016: Translating the virtual physiological human to the clinic. Interface Focus, 8 (1). doi:10.1098/rsfs.2017.0067
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Olofsson, S., Mehrian, M., Calandra, R., Geris, L., Deisenroth, M. P., & Misener, R. (2018). Bayesian Multi-Objective Optimisation with Mixed Analytical and Black-Box Functions: Application to Tissue Engineering. IEEE Transactions on Biomedical Engineering. doi:10.1109/TBME.2018.2855404
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Lang, A., Volkamer, A., Behm, L., Roblitz, S., Ehrig, R., Schneider, M., Geris, L., Wichard, J., & Buttgereit, F. (2018). In silico methods - Computational alternatives to animal testing. ALTEX: Alternatives to Animal Experimentation, 35 (1), 124-126. doi:10.14573/altex.1712031
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Lesage, R., Kerkhofs, J., & Geris, L. (2018). Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine. Frontiers in Bioengineering and Biotechnology, 6, 165. doi:10.3389/fbioe.2018.00165
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Kerckhofs, G., Stegen, S., van Gastel, N., Sap, A., Falgayrac, G., Penel, G., Durand, M., Luyten, F. P., Geris, L., Vandamme, K., Parac-Vogt, T., & Carmeliet, G. (2018). Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure. Biomaterials, 159, 1-12. doi:10.1016/j.biomaterials.2017.12.016
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Ji, W., Kerckhofs, G., Geeroms, C., Maréchal, M., Geris, L., & Luyten, F. P. (2018). Deciphering the combined effect of bone morphogenetic protein 6 (BMP6) and calcium phosphate on bone formation capacity of periosteum derived cells-based tissue engineering constructs. Acta Biomaterialia. doi:10.1016/j.actbio.2018.09.046
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Mendes, L. F., Katagiri, H., Tam, W. L., Chai, Y. C., Geris, L., Roberts, S. J., & Luyten, F. P. (2018). Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo. Stem Cell Research and Therapy, 9 (1), 42. doi:10.1186/s13287-018-0787-3
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Vavva, M. G., Grivas, K. N., Carlier, A., Polyzos, D., Geris, L., Van Oosterwyck, H., & Fotiadis, D. I. (2018). Effect of ultrasound on bone fracture healing: A computational bioregulatory model. Computers in Biology and Medicine, 100, 74-85. doi:10.1016/j.compbiomed.2018.06.024
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Carlier, A., Vasilevich, A., de Boer, J., Geris, L., & Maréchal, M. (Other coll.). (2018). In silico clinical trials for pediatric orphan diseases. Scientific Reports, 8 (1), 2465. doi:10.1038/s41598-018-20737-y
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Mehrian, M., Guyot, Y., Papantoniou, I., Olofsson, S., Sonnaert, M., Misener, R., & Geris, L. (2017). Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization. Biotechnology and Bioengineering. doi:10.1002/bit.26500
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Gupta, P., Geris, L., Luyten, F. P., & Papantoniou, I. (2017). An Integrated Bioprocess for the Expansion and Chondrogenic Priming of Human Periosteum-Derived Progenitor Cells in Suspension Bioreactors. Biotechnology Journal. doi:10.1002/biot.201700087
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Fernando, W. A., Papantoniou, I., Mendes, L. F., Hall, G. N., Bosmans, K., Tam, W. L., Teixeira, L. M., Moos, M. J., Luyten, F., & Geris, L. (2017). Limb derived cells as a paradigm for engineering self-assembling skeletal tissues. Journal of Tissue Engineering and Regenerative Medicine. doi:10.1002/term.2498
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Lammens, J., Maréchal, M., Geris, L., Van Der Aa, J., Van Hauwermeiren, H., Luyten, F. P., & Delport, H. (2017). Warning about the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model. Tissue Engineering. Part C, Methods, 23 (11), 694-699. doi:10.1089/ten.tec.2017.0147
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Manhas, V., Guyot, Y., Kerckhofs, G., Chai, Y. C., & Geris, L. (2016). Computational modelling of local calcium ions release from calcium phosphate-based scaffolds. Biomechanics and Modeling in Mechanobiology. doi:10.1007/s10237-016-0827-9
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Bajger, P., Ashbourn, J., Manhas, V., Guyot, Y., Lietaert, K., & Geris, L. (2016). Mathematical modelling of the degradation behaviour of biodegradable metals. Biomechanics and Modeling in Mechanobiology. doi:10.1007/s10237-016-0812-3
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Kerckhofs, G., Durand, M., Vangoitsenhoven, R., Marin, C., Van der Schueren, B., Carmeliet, G., Luyten, F. P., Geris, L., & Vandamme, K. (2016). Changes in bone macro- and microstructure in diabetic obese mice revealed by high resolution microfocus X-ray computed tomography. Scientific Reports, 6, 35517. doi:10.1038/srep35517
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Bolander, J., Ji, W., Geris, L., Bloemen, V., Chai, Y. C., Schrooten, J., & Luyten, F. P. (2016). The combined mechanism of bone morphogenetic protein- and calcium phosphate-induced skeletal tissue formation by human periosteum derived cells. European Cells and Materials, 31, 11-25. doi:10.22203/eCM.v031a02
Peer reviewed

Guyot, Y., Papantoniou, I., Luyten, F. P., & Geris, L. (2016). Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold. Biomechanics and Modeling in Mechanobiology, 15 (1), 169-80. doi:10.1007/s10237-015-0753-2
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Kerckhofs, G., Chai, Y. C., Luyten, F. P., & Geris, L. (2016). Combining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation. Acta Biomaterialia, 35, 330-40. doi:10.1016/j.actbio.2016.02.037
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Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F. P., Post, J. N., & Geris, L. (2016). A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy. PLoS ONE, 11 (8), 0162052. doi:10.1371/journal.pone.0162052
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Bolander, J., Chai, Y. C., Geris, L., Schrooten, J., Lambrechts, D., Roberts, S. J., & Luyten, F. P. (2016). Early BMP, Wnt and Ca(2+)/PKC pathway activation predicts the bone forming capacity of periosteal cells in combination with calcium phosphates. Biomaterials, 86, 106-18. doi:10.1016/j.biomaterials.2016.01.059
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Mendes, L. F., Tam, W. L., Chai, Y. C., Geris, L., Luyten, F. P., & Roberts, S. J. (2016). Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells. Tissue Engineering. Part C, Methods, 22 (5), 473-86. doi:10.1089/ten.TEC.2015.0436
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Guyot, Y., Smeets, B., Odenthal, T., Subramani, R., Luyten, F. P., Ramon, H., Papantoniou, I., & Geris, L. (2016). Immersed Boundary Models for Quantifying Flow-Induced Mechanical Stimuli on Stem Cells Seeded on 3D Scaffolds in Perfusion Bioreactors. PLoS Computational Biology, 12 (9), 1005108. doi:10.1371/journal.pcbi.1005108
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Geris, L., Guyot, Y., Schrooten, J., & Papantoniou, I. (2016). In silico regenerative medicine: how computational tools allow regulatory and financial challenges to be addressed in a volatile market. Interface Focus, 6 (2), 20150105. doi:10.1098/rsfs.2015.0105
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carlier, A., brems, H., ashbourn, J. M. A., nica, I., legius, E., & Geris, L. (2016). Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study. Scientific Reports, 7, 20010. doi:10.1038/srep20010
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Kerkhofs, J., & Geris, L. (11 June 2015). A semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks. PLoS ONE, 10 (6), 0130033. doi:10.1371/journal.pone.0130033
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Carlier, A., Geris, L., Lammens, J., & Van Oosterwyck, H. (2015). Bringing computational models of bone regeneration to the clinic. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 7 (4), 183-94. doi:10.1002/wsbm.1299
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Sonnaert, M., Kerckhofs, G., Papantoniou, I., Van Vlierberghe, S., Boterberg, V., Dubruel, P., Luyten, F. P., Schrooten, J., & Geris, L. (2015). Multifactorial Optimization of Contrast-Enhanced Nanofocus Computed Tomography for Quantitative Analysis of Neo-Tissue Formation in Tissue Engineering Constructs. PLoS ONE, 10 (6), 0130227. doi:10.1371/journal.pone.0130227
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Vavva, M. G., Grivas, K. N., Carlier, A., Polyzos, D., Geris, L., Van Oosterwyck, H., & Fotiadis, D. I. (2015). A mechano-regulatory model for bone healing predictions under the influence of ultrasound. Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2015, 921-4. doi:10.1109/EMBC.2015.7318513
Peer reviewed

Guyot, Y., Luyten, F. P., Schrooten, J., Papantoniou, I., & Geris, L. (2015). A Three-Dimensional Computational Fluid Dynamics Model Of Shear Stress Distribution During Neotissue Growth In A Perfusion Bioreactor. Biotechnology and Bioengineering. doi:10.1002/bit.25672
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Carlier, A., Lammens, J., Van Oosterwyck, H., & Geris, L. (2015). Computational modeling of bone fracture non-unions: four clinically relevant case studies. In Silico Cell and Tissue Science, 2, 1. doi:10.1186/s40482-015-0004-x
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Leijten, J., Chai, Y. C., Papantoniou, I., Geris, L., Schrooten, J., & Luyten, F. P. (2015). Cell based advanced therapeutic medicinal products for bone repair: Keep it simple? Advanced Drug Delivery Reviews, 84, 30-44. doi:10.1016/j.addr.2014.10.025
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Carlier, A., Geris, L., Gastel, N. V., Carmeliet, G., & Van Oosterwyck, H. (2015). Oxygen as a critical determinant of bone fracture healing-a multiscale model. Journal of Theoretical Biology, 365, 247-64. doi:10.1016/j.jtbi.2014.10.012
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Papantoniou, I., Guyot, Y., Sonnaert, M., Kerckhofs, G., Luyten, F. P., Geris, L., & Schrooten, J. (2014). Spatial optimization in perfusion bioreactors improves bone tissue-engineered construct quality attributes. Biotechnology and Bioengineering. doi:10.1002/bit.25303
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Guyot, Y., papantoniou, I., Chai, Y. C., Van Bael, S., Schrooten, J., & Geris, L. (2014). A computational model for cell/ECM growth on 3D surfaces using the level set method: a bone tissue engineering case study. Biomechanics and Modeling in Mechanobiology. doi:10.1007/s10237-014-0577-5
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Chai, Y. C., Geris, L., Bolander, J., Pyka, G., Van Bael, S., Luyten, F. P., & Schrooten, J. (2014). In vivo ectopic bone formation by devitalized mineralized stem cell carriers produced under mineralizing culture condition. BioResearch Open Access, 3 (6), 265-77. doi:10.1089/biores.2014.0050
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Geris, L. (2014). Regenerative orthopaedics: in vitro, in vivo ... in silico. International Orthopaedics, 38 (9), 1771-8. doi:10.1007/s00264-014-2419-6
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Carlier, A., van Gastel, N., Geris, L., Carmeliet, G., & Van Oosterwyck, H. (2014). Size does matter: an integrative in vivo-in silico approach for the treatment of critical size bone defects. PLoS Computational Biology, 10 (11), 1003888. doi:10.1371/journal.pcbi.1003888
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Braem, A., Van Mellaert, L., Mattheys, T., Hofmans, D., De Waelheyns, E., Geris, L., Anne, J., Schrooten, J., & Vleugels, J. (2014). Staphylococcal biofilm growth on smooth and porous titanium coatings for biomedical applications. Journal of Biomedical Materials Research. Part A, 102 (1), 215-24. doi:10.1002/jbm.a.34688
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Kerckhofs, G., Sainz, J., Maréchal, M., Wevers, M., Van de Putte, T., Schrooten, J., & Geris, L. (2013). Contrast-enhanced nanofocus X-ray computed tomography allows virtual 3D histopathology and morphometric analysis of osteoarthritis in small animal models. Cartilage. doi:10.1177/1947603513501175
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Van Schepdael, A., Vander Sloten, J., & Geris, L. (2013). A mechanobiological model of orthodontic tooth movement. Biomechanics and Modeling in Mechanobiology. doi:10.1007/s10237-012-0396-5
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Van Schepdael, A., Vander Sloten, J., & Geris, L. (2013). Mechanobiological modeling can explain orthodontic tooth movement: three case studies. Journal of Biomechanics, 46 (3), 470-7. doi:10.1016/j.jbiomech.2012.10.037
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Van Schepdael, A., Geris, L., & Vander Sloten, J. (2013). Analytical determination of stress patterns in the periodontal ligament during orthodontic tooth movement. Medical Engineering and Physics, 35 (3), 403-10. doi:10.1016/j.medengphy.2012.09.008
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Van Schepdael, A., Ashbourn, J. M. A., Beard, R., Miller, J. J., & Geris, L. (2013). Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis. Computer Methods in Biomechanics and Biomedical Engineering. doi:10.1080/10255842.2013.773979
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Papantoniou, I., Sonnaert, M., Geris, L., Luyten, F. P., Schrooten, J., & Kerckhofs, G. (2013). Three dimensional characterization of tissue-engineered constructs by contrast enhanced nanofocus computed tomography. Tissue Engineering. Part C, Methods. doi:10.1089/ten.tec.2013.0041
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Kerkhofs, J., Roberts, S. J., Luyten, F. P., Van Oosterwyck, H., & Geris, L. (2012). Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype. PLoS ONE. doi:10.1371/journal.pone.0034729
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Van Schepdael, A., De Bondt, K., Geris, L., & Vander Sloten, J. (2012). A visco-elastic model for the prediction of orthodontic tooth movement. Computer Methods in Biomechanics and Biomedical Engineering. doi:10.1080/10255842.2012.703182
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Carlier, A., Geris, L., Bentley, K., Carmeliet, G., Carmeliet, P., & Van Oosterwyck, H. (2012). MOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells. PLoS Computational Biology, 8 (10), 1002724. doi:10.1371/journal.pcbi.1002724
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Ashbourn, J., Miller, J., Reumers, V., Baekelandt, V., & Geris, L. (2012). A mathematical model of adult subventricular neurogenesis. Journal of the Royal Society, Interface. doi:10.1098/rsif.2012.0193
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Bolander, J., Roberts, S., Eyckmans, J., Geris, L., & Luyten, F. (2012). The Effect of Activating Fibroblast Growth Factor Receptor 3 Mutations on Osteogenic Differentiation and Ectopic Bone Formation by Human Periosteal Derived Cells. Journal of Tissue Science and Engineering, 2. doi:10.4172/2157-7552.S2-003
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Chai, Y. C., Carlier, A., Bolander, J., Roberts, S. J., Geris, L., Schrooten, J., Van Oosterwyck, H., & Luyten, F. P. (2012). Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies. Acta Biomaterialia, 8 (11), 3876-87. doi:10.1016/j.actbio.2012.07.002
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Chai, Y. C., Roberts, S. J., Desmet, E., Kerckhofs, G., van Gastel, N., Geris, L., Carmeliet, G., Schrooten, J., & Luyten, F. P. (2012). Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers. Biomaterials. doi:10.1016/j.biomaterials.2012.01.015
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Roberts, S. J., Geris, L., Kerckhofs, G., Desmet, E., Schrooten, J., & Luyten, F. P. (2011). The combined bone forming capacity of human periosteal derived cells and calcium phosphates. Biomaterials, 32 (19), 4393-405. doi:10.1016/j.biomaterials.2011.02.047
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Peiffer, V., Gerisch, A., Vandepitte, D., VanOosterwyck, H., & Geris, L. (2011). A hybrid bioregulatory model of angiogenesis during bone fracture healing. Biomechanics and Modeling in Mechanobiology, 10 (3), 383-395. doi:10.1007/s10237-010-0241-7
Peer Reviewed verified by ORBi

Carlier, A., Chai, Y. C., Moesen, M., Theys, T., Schrooten, J., Van Oosterwyck, H., & Geris, L. (2011). Designing optimal calcium phosphate scaffold-cell combinations using an integrative model-based approach. Acta Biomaterialia, 7 (10), 3573-85. doi:10.1016/j.actbio.2011.06.021
Peer Reviewed verified by ORBi

Geris, L., Ashbourn, J. M. A., & Clarke, T. (2011). Continuum-level modelling of cellular adhesion and matrix production in aggregates. Computer Methods in Biomechanics and Biomedical Engineering, 14 (5), 403-10. doi:10.1080/10255842.2010.539209
Peer Reviewed verified by ORBi

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2011). Computational modelling of biomaterial surface interactions with blood platelets and osteoblastic cells for the prediction of contact osteogenesis. Acta Biomaterialia, 7 (2), 779-90. doi:10.1016/j.actbio.2010.09.025
Peer Reviewed verified by ORBi

Geris, L., Reed, A. A. C., Vander Sloten, J., Simpson, A. H. R. W., & Van Oosterwyck, H. (September 2010). Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach. PLoS Computational Biology, 6 (9), 1000915. doi:10.1371/journal.pcbi.1000915
Peer Reviewed verified by ORBi

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (March 2010). Connecting biology and mechanics in fracture healing: an integrated mathematical modeling framework for the study of nonunions. Biomechanics and Modeling in Mechanobiology, 9 (6), 713-724. doi:10.1007/s10237-010-0208-8
Peer Reviewed verified by ORBi

Demol, J., Lambrechts, D., Geris, L., Schrooten, J., & Van Oosterwyck, H. (2010). Towards a quantitative understanding of oxygen tension and cell density evolution in fibrin hydrogels. Biomaterials, 32 (1), 107-118. doi:10.1016/j.biomaterials.2010.08.093
Peer Reviewed verified by ORBi

Geris, L., Van Liedekerke, P., Smeets, B., Tijskens, E., & Ramon, H. (2010). A cell based modelling framework for skeletal tissue engineering applications. Journal of Biomechanics, 43 (5), 887-892. doi:10.1016/j.jbiomech.2009.11.010
Peer Reviewed verified by ORBi

Geris, L., Schugart, R., & Van Oosterwyck, H. (2010). In silico design of treatment strategies in wound healing and bone fracture healing. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, 368 (1920), 2683-2706. doi:10.1098/rsta.2010.0056
Peer Reviewed verified by ORBi

Geris, L., Gerisch, A., & Schugart, R. C. (2010). Mathematical Modeling in Wound Healing, Bone Regeneration and Tissue Engineering. Acta Biotheoretica, 58 (4), 355-367. doi:10.1007/s10441-010-9112-y
Peer Reviewed verified by ORBi

Ashbourn, J. M. A., Geris, L., Gerisch, A., & Young, C. J. S. (2010). Numerical simulation of two-dimensional and three-dimensional axisymmetric advection-diffusion systems with complex geometries using finite-volume methods. Proceedings of the Royal Society. Mathematical, Physical and Engineering Sciences, 466 (2118), 1621-1643. doi:10.1098/rspa.2009.0527
Peer Reviewed verified by ORBi

Geris, L., Vandamme, K., Naert, I., Vander Sloten, J., Van Oosterwyck, H., & Duyck, J. (2010). Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study. Tissue Engineering. Part A, 16 (11), 3353-3361. doi:10.1089/ten.tea.2010.0130
Peer Reviewed verified by ORBi

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2009). Modelling the early phases of bone regeneration around an endosseous oral implant. Computer Methods in Biomechanics and Biomedical Engineering, 12 (4), 459-468. doi:10.1080/10255840802687392
Peer Reviewed verified by ORBi

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2009). In silico biology of bone modelling and remodelling: regeneration. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, 367 (1895), 2031-53. doi:10.1098/rsta.2008.0293
Peer Reviewed verified by ORBi

Geris, L., Vandamme, K., Naert, I., Vander Sloten, J., Duyck, J., & Van Oosterwyck, H. (2009). Numerical simulation of bone regeneration in a bone chamber. Journal of Dental Research, 88 (2), 158-63. doi:10.1177/0022034508329603
Peer Reviewed verified by ORBi

Geris, L., Vandamme, K., Naert, I., Vander Sloten, J., Duyck, J., & Van Oosterwyck, H. (2008). Application of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber. Journal of Biomechanics, 41 (1), 145-154. doi:10.1016/j.jbiomech.2007.07.008
Peer Reviewed verified by ORBi

Geris, L., Gerisch, A., Vander Sloten, J., Weiner, R., & Van Oosterwyck, H. (2008). Angiogenesis in bone fracture healing: a bioregulatory model. Journal of Theoretical Biology, 251 (1), 137-58. doi:10.1016/j.jtbi.2007.11.008
Peer Reviewed verified by ORBi

Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R., & Duyck, J. (2007). The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit. European Journal of Oral Sciences, 115 (1), 21-9. doi:10.1111/j.1600-0722.2007.00416.x
Peer Reviewed verified by ORBi

Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R., & Duyck, J. (2007). Histodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit. Clinical Oral Implants Research, 18 (4), 471-80. doi:10.1111/j.1600-0501.2007.01339.x
Peer Reviewed verified by ORBi

Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R., & Duyck, J. (2007). Influence of controlled immediate loading and implant design on peri-implant bone formation. Journal of Clinical Periodontology, 34 (2), 172-81. doi:10.1111/j.1600-051X.2006.01014.x
Peer Reviewed verified by ORBi

Duyck, J., Vandamme, K., Geris, L., Van Oosterwyck, H., De Cooman, M., Vandersloten, J., Puers, R., & Naert, I. (2006). The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Archives of Oral Biology, 51 (1), 1-9. doi:10.1016/j.archoralbio.2005.04.003
Peer Reviewed verified by ORBi

Geris, L., Gerisch, A., Maes, C., Carmeliet, G., Weiner, R., Vander Sloten, J., & Van Oosterwyck, H. (2006). Mathematical modeling of fracture healing in mice: comparison between experimental data and numerical simulation results. Medical and Biological Engineering and Computing, 44 (4), 280-9. doi:10.1007/s11517-006-0040-6
Peer Reviewed verified by ORBi

Geris, L., Andreykiv, A., Van Oosterwyck, H. V., Vander Sloten, J., van Keulen, F., Duyck, J., & Naert, I. (2004). Numerical simulation of tissue differentiation around loaded titanium implants in a bone chamber. Journal of Biomechanics, 37 (5), 763-9. doi:10.1016/j.jbiomech.2003.09.026
Peer Reviewed verified by ORBi

De Gersem, H., & Geris, L. (2003). Zoektocht naar een levende prothese. Ingenieursblad (Het), 72 (8/9), 54-60.
Peer reviewed

Geris, L., Van Oosterwyck, H., Vander Sloten, J., Duyck, J., & Naert, I. (2003). Assessment of mechanobiological models for the numerical simulation of tissue differentiation around immediately loaded implants. Computer Methods in Biomechanics and Biomedical Engineering, 6 (5-6), 277-88. doi:10.1080/10255840310001634412
Peer Reviewed verified by ORBi

Articles accepted in journal without reviewing

Geris, L. (2020). In silico tools predict effects of drugs on bone remodelling. Nature Reviews Rheumatology. doi:10.1038/s41584-020-0457-6

Articles accepted in conference proceedings

Maia Ladeira, L. C., Gamba, A., Lesage, R. L., Verhoeven, A., van Ertvelde, J., Jiang, J., Roodzant, D. L., Teunis, M., Jover, R., Vanhaecke, T., Vinken, M., Heuseinkveld, H., Geris, L., & Staumont, B. (2022). Designing physiological maps as a tool to study liver toxicology. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV.
Editorial reviewed

Barnes, D., Irvine, A., Gamba, A., Maia Ladeira, L. C., Staumont, B., Yang, H., Steffensen, I.-L., Geris, L., Janssen, M., & Masereeuw, R. (2022). Development of an adverse outcome pathway for kidney tubular necrosis. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV.
Editorial reviewed

Berkhout, J., Piersma, A., Legler, J., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R. L., Geris, L., & Heuseinkveld, H. (2022). Computational modelling of neural tube closure defects. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV.
Editorial reviewed

Maia Ladeira, L. C., Gamba, A., Lesage, R. L., Verhoeven, A., Jiang, J., van Ertvelde, J., Jover, R., Vanhaecke, T., Mathieu, V., Geris, L., & Staumont, B. (2022). Developing a physiological map as a framework to study chemical- induced liver steatosis. In VPHi, VPH2022 Virtual Physiological Human Conference. Brussels, Belgium: VPHi.
Editorial reviewed

Gamba, A., Maia Ladeira, L. C., Lesage, R. L., Roodzant, D. L., Barnes, D. A., Janssen, M. J., Teunis, M., Masereeuw, R., Geris, L., & Staumont, B. (2022). From Physiological Map to Ontology Unravelling Kidney Toxicity From Physiological Map to Ontology Unravelling Kidney Toxicity. In VPHi, VPH2022 Virtual Physiological Human Conference. Brussels, Belgium: VPHi.
Editorial reviewed

Maia Ladeira, L. C., Gamba, A., Lesage, R., Ertvelde, J. V., Jiang, J., Verhoeven, A., Roodzant, D., Teunis, M., Jover, R., Vanhaecke, T., Vinken, M., Geris, L., & Staumont, B. (September 2022). P11-09 Physiology-based framework to study chemical-induced cholestasis. Toxicology Letters, 368, 165-S166. doi:10.1016/j.toxlet.2022.07.459
Peer Reviewed verified by ORBi

Kuchovska, E., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R., Steffensen, I.-L., Soop, G. L., Hofer, T., Myhre, O., Dirven, H., Geris, L., & Fritsche, E. (September 2022). SOC-II-09 First steps for creating an ontology for cognitive function defects for regulatory application. Toxicology Letters, 368, 35-S36. doi:10.1016/j.toxlet.2022.07.112
Peer Reviewed verified by ORBi

Staumont, B., Maia Ladeira, L. C., Gamba, A., Lesage, R., Verhoeven, A., Jiang, J., Ertvelde, J. V., Barnes, D. A., Janssen, M. J., Kuchovska, E., Berkhout, J., Roodzant, D., Teunis, M., Bozada, T., Luechtefeld, T. H., Jover, R., Vanhaecke, T., Vinken, M., Masereeuw, R., ... Geris, L. (September 2022). SOC-VI-08 Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies. Toxicology Letters, 368, 77-S78. doi:10.1016/j.toxlet.2022.07.228
Peer Reviewed verified by ORBi

Gamba, A., Maia Ladeira, L. C., Lesage, R., Barnes, D. A., Roodzant, D., Teunis, M., Janssen, M. J., Masereeuw, R., Geris, L., & Staumont, B. (2022). P04-06 New approaches for evaluating kidney toxicity using physiological maps. Toxicology Letters. doi:10.1016/j.toxlet.2022.07.290
Peer Reviewed verified by ORBi

Barnes, D., Irvine, A., Gamba, A., Staumont, B., Maia Ladeira, L. C., Yang, H., Steffensen, I.-L., Geris, L., Janssen, M., & Masereeuw, R. (September 2022). P01-07 Development of an adverse outcome pathway for kidney tubular necrosis. Toxicology Letters, 368, 86-S87. doi:10.1016/j.toxlet.2022.07.251
Peer Reviewed verified by ORBi

Geris, L. (2019). Digital twins in tissue engineering: from bench to bedside via the computer. In Abstract book of CMBBE2019.
Peer reviewed

Drion, P., Tirelli, E., Geris, L., & Rentier, B. (2018). InfOPAL_Les actes du Colloque_De l'engagement des chercheurs au service de l'animal et de la recherche. In OPAL, Les actes du Colloque (pp. 26-37). Paris, France: Opal.

Mehrian, M., Papantoniou, I., Lambrechts, T., & Geris, L. (2018). Computational modelling of the effect of growth factors on human mesenchymal stem cell proliferation in 3D porous scaffolds. In Proceedings of the Virtual Physiological Human conference (VPH), Zaragoza, Spain, 5-7 September 2018.
Peer reviewed

Mehrian, M., olofsson, S., Misener, R., & Geris, L. (2018). Multi-objective optimization of cost-efficient neotissue growth inside 3D scaffolds using evolutionary algorithms. In Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE).
Peer reviewed

Mehrian, M., Papantoniou, I., Lambrechts, T., & Geris, L. (2018). Computational modelling of human mesenchymal stem cell proliferation and extra cellular matrix production in 3D porous scaffolds in a perfusion bioreactor. In Proceedings of the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE).
Peer reviewed

olofsson, S., Mehrian, M., Geris, L., Calandra, R., Deisenrotha, & Ruth, M. (2017). Bayesian Multi-Objective Optimisation of Neotissue Growth in a Perfusion Bioreactor Set-up. In Computer Aided Chemical Engineering. Elsevier. doi:10.1016/B978-0-444-63965-3.50361-5
Peer reviewed

Mehrian, M., guyot, Y., Papantoniou, I., & Geris, L. (2017). Model-Based Optimization of the Medium Refreshment Regime During Neotissue Growth in a Perfusion Bioreactor. In Proceedings of the Foundations of Computer Aided Process Operations / Chemical Process Control (FOCAPO/CPC).
Peer reviewed

Mehrian, M., guyot, Y., Papantoniou, I., & Geris, L. (2016). Improving Perfusion Bioreactor Yields by Using Particle Swarm Optimization. In Proceedings of the 15th Belgian National Day on Biomedical Engineering.
Peer reviewed

Mehrian, M., Guyot, Y., Papantoniou, I., & Geris, L. (2016). Optimizing the medium refreshment regime during neotissue growth in a perfusion bioreactor described by a reduced computational model capturing curvature and shear stress distribution. In Proceedings of the 4th Belgian Symposium on Tissue Engineering (BSTE).
Peer reviewed

Mehrian, M., Guyot, Y., & Geris, L. (2015). A reduced model developed for describing neotissue growth during dynamic bioreactor culture. In Proceedings of the IEEE-EMBS Benelux Chapter Meeting.
Peer reviewed

Sonnaert, M., Papantoniou, I., Geris, L., Luyten, F., Schrooten, J., & Kerckhofs, G. (2013). Contrast enhanced nanoCT for 3D quantitative and spatial analysis of in vitro manufactured extracellular matrix in metallic tissue engineering scaffolds. In Abstract book User Meeting Bruker MicroCT 2013 (pp. 36-41).
Peer reviewed

Van Hove, A., Geeroms, C., Maréchal, M., Van Houdt, L., Bosmans, K., Geris, L., Luyten, F., Schrooten, J., & Kerckhofs, G. (2013). Micro-CT evaluation of the effect of material, donor and implantation site variability on the bone forming capacity of progenitor cell/CaP-collagen constructs implanted ectopically in nude mice. In Abstract book User Meeting Bruker MicroCT 2013 (pp. 122-127).
Peer reviewed

Kerkhofs, J., Geris, L., Bosmans, B., & Van Oosterwyck, H. (2012). Coupling Cell Mechanics and Intracellular Signalling: Mechanotransduction through ERK. In J. Middleton (Ed.), The Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Hotel Berlin, Berlin, Germany, April 7th – 11th, 2012 pages:0-0. ARUP.
Peer reviewed

Carlier, A., Geris, L., & Van Oosterwyck, H. (2012). Tip cells at the top: multiscale modeling of angiogenesis during fracture healing. In Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) - Proceedings.
Peer reviewed

Carlier, A., Chai, Y. C., Theys, T., Moesen, M., Schrooten, J., Van Oosterwyck, H., & Geris, L. (2011). Optimization of calcium phosphate scaffold-cell combinations using an integrative model based approach. In International Conference on Tissue Engineering (ECCOMAS) - proceedings.
Peer reviewed

Kerckhofs, G., Geris, L., Roberts, S., Braem, A., Wevers, M., Luyten, F., & Schrooten, J. (2011). Microfocus X-ray computed tomography based characterization of calcium phosphate–stem cells constructs combined with empirical modelling as a tool for the prediction of bone formation. In Histology and Histopathology.
Peer reviewed

Demol, J., Lambrechts, D., Geris, L., Schrooten, J., & Van Oosterwyck, H. (2010). Experimentally-informed Mathematical Modelling of Oxygen Tension, Cell Viability and Proliferation in Fibrin Hydrogels. In Proceedings of the TERMIS-EU meeting.
Peer reviewed

Geris, L., Vandeput, M., Roberts, S., Eyckmans, J., Luyten, F., & Van Oosterwyck, H. (2010). Cross-talk Modeling of Wnt, BMP and ERK Pathways during Osteochondrogenic Differentiation. In Proceedings of the TERMIS-EU meeting.
Peer reviewed

Van Schepdael, J., Vander Sloten, J., & Geris, L. (2010). The biology of orthodontic tooth movement: a mathematical model. In J. Middleton, C. Jacobs, B. Walker, ... Atienza (Eds.), 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering. Cardiff, United Kingdom: The Cardiff Medicentre.

Van Schepdael, A., Vander Sloten, J., & Geris, L. (2010). A mathematical model describing the biology of orthodontic tooth movement. In J. Goh Cho Hong & C. Teck Lim (Eds.), proceedings of the 6th world congress on biomechanics.
Peer reviewed

Geris, L., Van Liedekerke, P., Smeets, B., Tijskens, E., & Ramon, H. (2010). A single cell-based modelling framework for bone tissue engineering. In Proceedings of the 17th conference of the European Society of Biomechanics.

Geris, L., Clarke, T., & Ashbourn, J. (2010). Mathematical modelling of cell aggregates for bone tissue engineering using continuum methods. In J. Middleton, C. Jacobs, B. Walker, ... C. Atienza (Eds.), 9th International symposium on Computer Methods in Biomechanics and Biomedical Engineering. Cardiff, United Kingdom: The Cardiff Medicentre.
Peer reviewed

Demol, J., Lambrechts, D., Geris, L., Schrooten, J., & Van Oosterwyck, H. (2010). Experimental and computational study of the correlation between oxygen tension, cell viability and proliferation in fibrin hydrogels. In Proceedings of the 17th conference of the European Society of Biomechanics.
Peer reviewed

Geris, L., Peiffer, V., Gerisch, A., & Van Oosterwyck, H. (2010). A hybrid model for the simulation of angiogenesis during bone fracture healing. In Proceedings of the 17th conference of the European Society of Biomechanics.

Van Oosterwyck, H., Truscello, S., Demol, J., Lambrechts, D., Moesen, M., Schrooten, J., & Geris, L. (2010). In vivo, in vitro, in silico: computational tools for tissue engineering. In proceedings of the 2nd International Conference on Innovation for Sustainable Production i-SUP.
Peer reviewed

Van Oosterwyck, H., Truscello, S., Demol, J., Lambrechts, D., Moesen, M., Schrooten, J., & Geris, L. (2010). Optimizing The Micro-Environment In A Tissue Engineering Scaffold: A Computational Approach. In proceedings of the Materialise World Conference.
Peer reviewed

Geris, L., Vandeput, M., Roberts, S., Eyckmans, J., & Van Oosterwyck, H. (2009). Crosstalk Modeling of Wnt, BMP and ERK Pathways during osteochondrogenic differentiation. In proceedings of the International Symposium on Biomechanics and Biology of Bone Regeneration “From Functional Assessment To Guided Tissue Formation.
Peer reviewed

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2009). Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration around Endosseous Oral Implants: In Silico Modeling. In K. Miller & P. M. F. Nielsen (Eds.), MICCAI 2009 Workshop Proceedings (pp. 87-97).
Peer reviewed

van Schepdael, A., Vander Sloten, J., & Geris, L. (2009). The biology of bone formation in orthodontic tooth movement: a mathematical model. In Proceedings of the International Conference on Mathematical Biology 2009.
Peer reviewed

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2009). Design of treatment strategies for an atrophic nonunion case in fracture healing. In proceedings of the IVth International Conference on Computational Bioengineering.
Peer reviewed

Geris, L., Vander Sloten, H., & Van Oosterwyck, H. (2009). Mathematical modeling of bone regeneration during fracture healing. In proceedings of the National Conference on Theoretical and Applied Mechanics.
Peer reviewed

Geris, L. (2009). Modelling at the biological/biomechanical interface: fracture healing case studies. In Exploring the biological/biomechanics interface.
Peer reviewed

Geris, L., Peiffer, V., Demol, J., & Van Oosterwyck, H. (July 2008). Modelling of in vitro mesenchymal stem cell cultivation, chondrogenesis and osteogenesis. Journal of Biomechanics, 41, 466. doi:10.1016/S0021-9290(08)70465-2
Peer Reviewed verified by ORBi

Van Oosterwyck, H., Vander Sloten, J., & Geris, L. (2008). A mathematical model of bone regeneration including angiogenesis: relevance for tissue engineering strategies. European Cells and Materials, Vol. 14 (Suppl. 1,), 29.
Peer reviewed

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2008). Computational modelling of peri-implant bone healing considering cell-biomaterial interactions. In A. Arbor (Ed.), Proceedings of the North American Congress on Biomechanics.
Peer reviewed

Geris, L., Vander Sloten, J., & VanOosterwyck, H. (2008). Mathematical modeling of fracture healing: coupling between mechanics, angiogenesis and osteogenesis. In IFMBE Proceedings 22 (pp. 2651-2654). Berlin Heidelberg, Germany: Springer-Verlag. doi:10.1007/978-3-540-89208-3_636
Peer reviewed

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2008). An integrated mathematical modelling framework for the study of bone fracture healing. Journal of Biomechanics, 41, 107. doi:10.1016/S0021-9290(08)70107-6
Peer Reviewed verified by ORBi

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2008). Mathematical modelling of bone regeneration including angiogenesis: design of treatment strategies for atrophic non-unions. Proceedings of the 54th Annual Meeting of the Orthopaedic Research Society, 1024.
Peer reviewed

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2008). Modelling of peri-implant osteogenesis by means of a fracture healing mode. Journal of Biomechanics, 41 (S1), 289.
Peer Reviewed verified by ORBi

Geris, L., Vander Sloten, J., & VanOosterwyck, H. (2008). Mathematical modelling of atrophic non-union and its treatment. In Proceedings of the International symposium on Biomechanics and Biology of Bone Healing.
Peer reviewed

Van Schepdael, A., Geris, L., & Vander Sloten, J. (2008). Development of a mechanobiological model of bone formation in orthodontic tooth movement. In Proceedings of the European Conference on Mathematical and Theoretical Biology.
Peer reviewed

Geris, L., Gerisch, A., Weiner, R., Vander Sloten, J., & VanOosterwyck, H. (2008). A mechanobioregulatory model for the study of bone fracture healing. In Proceedings of the European Conference on Mathematical and Theoretical Biology.
Peer reviewed

Geris, L., VanderSloten, J., & VanOosterwyck, H. (2008). Mathematical modelling of bone regeneration during fracture healing. In proceedings of the OPTEC Topical Workshop on Parameter Estimation in Differential Equations.
Peer reviewed

Amor, N., Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2008). Computational modelling of peri-implant healing. In J. Middleton, M. L. Jones, ... N. Shrive (Eds.), Proceedings of the 8th interantional symposium on Computer Methods in Biomechanics and Biomedical Engineering. The Cardiff Medicentre.
Peer reviewed

Geris, L., Vandamme, K., Duyck, J., Naert, L., Vander Sloten, J., & Van Oosterwyck, H. (2007). A coupled mechanobioregulatory model for the simulation of peri-implant bone formation in an in vivo bone chamber. In Proceedings of the second thematic workshop of the European Society of Biomechanics on Finite Element modelling in Biomechanis and Mechanobiology (pp. 128-129).
Peer reviewed

Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R., & Duyck, J. (2007). Impact of implant geometry and loading on early bone formation, Clinical Oral Implants Research. Clinical Oral Implants Research, 18 (5), 71-72.
Peer Reviewed verified by ORBi

Van Oosterwyck, H., Vander Sloten, J., & Geris, L. (2007). Mathematical modelling of growth factor induced bone regeneration: importance of angiogenesis. Tissue Engineering, 1721-1722.
Peer Reviewed verified by ORBi

Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R., & Duyck, H. (2007). The effect of mechanical loading on peri-implant osteogenesis. In proceedings of the 17th annual meeting of the Dutch society for calcium and bone metabolism.
Peer reviewed

Vandamme, K., Naert, I., Geris, L., VanderSloten, J., Puers, R., & Duyck, J. (2007). Influence of immediate loading and implant design on bone formation. In Proceedings of the 85th General Session & Exhibition of the IADR.
Peer reviewed

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2006). A novel mathematical model to simulate and predict tissue regeneration. In J. Middleton, M. L. Jones, ... N. Shrive (Eds.), Proceedings of the 7th international symposium on Computer Methods in Biomechanics and Biomedical Engineering.

Geris, L., Vander Sloten, J., & Van Oosterwyck, H. (2006). Mathematical modeling of bone regeneration including the angiogenic process. Journal of Biomechanics, 39 (S1), 411-S412. doi:10.1016/S0021-9290(06)84671-3
Peer Reviewed verified by ORBi

Vandamme, K., Naert, I., Geris, L., Van Oosterwyck, H., VanderSloten, J., Puers, R., & Duyck, J. (2006). Bone Formation around Immediately Loaded Implants: a Bone Chamber Model. In Proceedings of the 84th General Session & Exhibition of the IADR.
Peer reviewed

Vandamme, K., Duyck, J., Geris, L., VanOosterwyck, H., De Cooman, M., Vander Sloten, J., Puers, R., & Naert, I. (September 2005). The influence of mechanical parameters on tissue differentiation and bone formation around immediately loaded implants in the bone chamber model. Computer Methods in Biomechanics and Biomedical Engineering, 8 (4), 275 - 276. doi:10.1080/10255840512331389325
Peer Reviewed verified by ORBi

Geris, L., Van Oosterwyck, H., Duyck, J., & Naert, I. (2005). Different mechanoregulatory models predict different patterns of tissue differentiation. In J. Middleton, M. L. Jones, ... N. Shrive (Eds.), Proceedings of the 6th international symposium on Computer Methods in Biomechanics and Biomedical Engineering.
Peer reviewed

Geris, L., Gerisch, A., Maes, C., Carmeliet, G., Weiner, R., Vander Sloten, J., & Van Oosterwyck, H. (2005). Tissue differentiation during fracture healing in mice: comparison of an experimental and numerical study. In Proceedings of the first thematic workshop of the European Society of Biomechanics on Mechanobiology of Cells and Tissue Engineering (pp. 35-36).
Peer reviewed

Vandamme, K., Duyck, J., Van Oosterwyck, H., Geris, L., Vander Sloten, J., De Cooman, M., Puers, R., & Naert, I. (2005). De invloed van mechanische parameters op de weefselrespons bij immediaat belaste titanium implantaten. In Proceedings van het Congres Verbond der Vlaamse Tandartsen.
Peer reviewed

Geris, L., Gerisch, A., Maes, C., Carmeliet, G., Weiner, R., Van Oosterwyck, H., & Vander Sloten, J. (2005). Numerical simulation and experimental validation of murine fracture healing. In Proceedings of the fifth national day on biomedical engineering.
Peer reviewed

Geris, L., Gerisch, A., Maes, C., Carmeliet, G., Weiner, R., Van Oosterwyck, H., & Vander Sloten, J. (2005). Numerical simulation and experimental validation of murine fracture healing. In Proceedings of the European Conference on Mathematical and Theoretical Biology.
Peer reviewed

Gerisch, A., & Geris, L. (2005). Efficient and robust simulation of tissue differentiation in fracture healing. In Proceedings of the European Conference on Mathematical and Theoretical Biology.
Peer reviewed

Vandamme, K., Duyck, J., Geris, L., Van Oosterwyck, H., De Cooman, M., Vander Sloten, J., Puers, R., & Naert, I. (2005). The influence of mechanical parameters on tissue differentiation and bone formation around immediately loaded implants in the bone chamber model. In Proceedings of the first thematic workshop of the European Society of Biomechanics on Mechanobiology of Cells and Tissue Engineering (pp. 23-24).
Peer reviewed

Duyck, J., Vandamme, K., Geris, L., Van Oosterwyck, H., De Cooman, M., Vander Sloten, J., & Naert, I. (2005). The effect of micromotion on tissues surrounding immediately loaded implants. Computer Methods in Biomechanics and Biomedical Engineering, 8 (S1), 93-94. doi:10.1080/10255840500180708
Peer Reviewed verified by ORBi

Van Oosterwyck, H., Geris, L., Gerisch, A., Vandamme, K., Duyck, J., De Cooman, M., Weiner, R., Puers, R., Naert, I., & Vander Sloten, J. (2004). Application of different mathematical models for the prediction of bone regeneration in an in vivo bone chamber. In Lecture notes of workshop Numerical models of bone adaptation and repair.
Peer reviewed

Geris, L., & Vander Sloten, J. (2004). Numerical simulation of tissue differentiation around loaded implants in a bone chamber. In In Proceedings of the Mini-Symposium Biomécanique de l'appareil locomoteur.
Peer reviewed

Geris, L., Van Oosterwyck, H., Duyck, J., De Cooman, M., Puers, R., Naert, I., & Vander Sloten, J. (2004). The mechanobiology of tissue differentiation around immediately loaded implants: a bone chamber experiment. In Proceedings of the 14th conference of the European Society of Biomechanics. Netherlands: s’Hertogenbosch.
Peer reviewed

Van Oosterwyck, H., Geris, L., Vander Sloten, J., Andreykiv, A., van Keulen, F., Duyck, J., & Naert, I. (2003). Numerical simulations of tissue ingrowth and differentiation around a loaded titanium implant in a bone chamber. In Proceedings of the symposium on integrated systems in dental healthcare.
Peer reviewed

Geris, L., Van Oosterwyck, H., Andreykiv, A., Vander Sloten, J., van Keulen, F., Duyck, J., & Naert, I. (2003). Numerical simulation of peri-implant tissue differentiation in a bone chamber. European Cells and Materials, 5 (2), 16-17.
Peer reviewed

Vandamme, K., Geris, L., Duyck, J., Van Oosterwyck, H., Vander Sloten, J., De Cooman, M., Puers, R., & Naert, I. (2003). Quantification of the role of mechanical parameters on the bone response around loaded titanium implants. European Cells and Materials, 5 (2), 96-97.
Peer reviewed

Van Oosterwyck, H. V., Geris, L., Duyck, J., De Cooman, M., Andreykiv, A., van Keulen, F., Puers, R., Naert, I., & Vander Sloten, J. (2003). Experimental and numerical study on mechanoregulation of tissue differentiation around a loaded implant in a bone chamber. In G. Bischoff & H.-J. Hein (Eds.), Proceedings of the seventh conference of ESEM.
Peer reviewed

Geris, L., Van Oosterwyck, H. V., Vander Sloten, J., Duyck, J., & Naert, I. (2003). Simulation of tissue ingrowth and differentiation around a loaded titanium implant in a bone chamber. In C. Veraart & P. Verdonck (Eds.), Proceedings of the third national day on biomedical engineering (pp. 50). Bruxelles, Belgium: Belgian Society Medical and Biological Engineering and Computing & National Committee Biomedical Engineering.
Peer reviewed

Geris, L., De Gersem, H., Van Cleynenbreugel, T., Van Oosterwyck, H., VanderSloten, J., & Van der Perre, G. (2002). Computer modelling techniques for trabecular bone tissue engineering scaffold design. In Proceedings of the second national day on biomedical engineering.
Peer reviewed

Oral presentations in conferences with scientific selection committee

Bekisz, S., Gautier, M., Mead, T., Bentley, K., Noël, A., & Geris, L. (07 September 2022). Computational insights on the roles of Dll4 – Notch and uPARAP in lymphangiogenic sprouts [Paper presentation]. VPH2022 - Virtual Physiological Human Conference, Porto, Portugal.
Peer reviewed

Bekisz, S., Gautier, M., Mead, T., Bentley, K., Noël, A., & Geris, L. (19 June 2022). Investigation of the role of Dll4–Notch and uPARAP in lymphangiogenic sprouts through agent-based modeling [Paper presentation]. Conference SBHD 2022, Nashville, United States.
Peer reviewed

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