Article (Scientific journals)
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
Koshmanova, Ekaterina; Berger, Alexandre; Beckers, Elise et al.
2023In JCI Insight
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Keywords :
General Medicine
Abstract :
[en] Background. The locus coeruleus (LC) is the primary source of norepinephrine in the brain and regulates arousal and sleep. Animal research shows that it plays important roles in the transition between sleep and wakefulness, and between slow wave sleep and rapid eye movement sleep (REMS). It is unclear, however, whether the activity of the LC predicts sleep variability in humans. Methods. We used 7 Tesla functional Magnetic Resonance Imaging, sleep electroencephalography (EEG) and a sleep questionnaire to test whether the LC activity during wakefulness was associated with sleep quality in 33 healthy younger (~22y; 28 women) and 19 older (~61y; 14 women) individuals. Results. We found that, in older, but not in younger participants, higher LC activity, as probed during an auditory attentional task, was associated with worse subjective sleep quality and with lower power over the EEG theta band during REMS. The results remained robust even when accounting for the age-related changes in the integrity of the LC. Conclusion. These findings suggest that LC activity correlates with the perception of the sleep quality and an essential oscillatory mode of REMS, and that the LC may be an important target in the treatment of sleep and age-related diseases.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Koshmanova, Ekaterina ;  Université de Liège - ULiège > Faculté de Médecine > Doct. scienc. biom. pharma. ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Berger, Alexandre 
Beckers, Elise  ;  Université de Liège - ULiège > GIGA
Campbell, Islay ;  Université de Liège - ULiège > GIGA
Mortazavi, Nasrin ;  Université de Liège - ULiège > GIGA
Sharifpour, Roya  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Paparella, Ilenia  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Balda Aizpurua, Fermin  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Berthomier, Christian 
Degueldre, Christian 
Salmon, Eric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Lamalle, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques
Bastin, Christine  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Van Egroo, Maxime 
Phillips, Christophe  ;  Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore)
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Chylinski, Daphné
Jacobs, Heidi I.L. 
Talwar, Puneet ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Sherif, Siya
Vandewalle, Gilles  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
More authors (13 more) Less
Language :
English
Title :
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
Publication date :
12 September 2023
Journal title :
JCI Insight
eISSN :
2379-3708
Publisher :
American Society for Clinical Investigation
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Actions de recherche concertées (ARC)
Funders :
FNS - Fonds National Suisse de la Recherche scientifique [CH]
FWB - Fédération Wallonie-Bruxelles [BE]
Fondation Recherche Alzheimer [BE]
Available on ORBi :
since 20 September 2023

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