Article (Scientific journals)
Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis.
Defresne, Marie-Paule; Rongy, A M; Greimers, Roland et al.
1986In Leukemia Research, 10 (7), p. 783 - 789
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Keywords :
Antibodies, Monoclonal; Antigens, Surface; Animals; Antibodies, Monoclonal/immunology; Antigens, Surface/analysis; Epithelium/pathology; Epithelium/radiation effects; Hematopoiesis/radiation effects; Leukemia, Radiation-Induced/immunology; Leukemia, Radiation-Induced/pathology; Mice; Mice, Inbred C57BL; Preleukemia/immunology; Preleukemia/pathology; Thymus Gland/immunology; Thymus Gland/pathology; Thymus Gland/radiation effects; lymphoepithelial interactions in vitro; Radiation-induced thymic lymphoma; thymic lymphopoiesis; thymic nurse cells; Hematology; Oncology; Cancer Research
Abstract :
[en] After a leukemogenic split dose course of irradiation, thymic nurse cells (TNCs) disappear. We have correlated this with the loss of an epithelial cell surface antigen (recognized by monoclonal antibody ER-TR3 and tentatively identified as Ia). In addition, epithelial cells have lost their capacity to interact with fetal thymocytes in vitro. Marrow grafting early after irradiation, that prevents the development of lymphomas, restores thymic nurse cells and thymocyte population. Such reconstitution and lymphoma prevention were not observed when marrow grafting was performed later (1 month after irradiation) during the preleukemic period.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences précliniques MI > Histologie - Cytologie
Rongy, A M;  Laboratory of Pathological Anatomy, University of Liège, Belgium
Greimers, Roland ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques
Boniver, Jacques ;  Université de Liège - ULiège > > Anatomie et cytologie pathologiques
Language :
English
Title :
Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis.
Publication date :
1986
Journal title :
Leukemia Research
ISSN :
0145-2126
Publisher :
Elsevier BV, England
Volume :
10
Issue :
7
Pages :
783 - 789
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRSM - Fonds de la Recherche Scientifique Médicale [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
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