Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis.

Defresne, Marie-Paule; Rongy, A M; Greimers, Roland; Boniver, Jacques

doi:10.1016/0145-2126(86)90298-5

Article (Scientific journals)

Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis.

Defresne, Marie-Paule; Rongy, A M; Greimers, Roland et al.

1986 • In Leukemia Research, 10 (7), p. 783 - 789

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/304504

DOI
10.1016/0145-2126(86)90298-5

PubMed
3736112

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

DefresneMP_21_Cellular-aspects-radiation-1986.pdf

Publisher postprint (664.23 kB)

Download

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Antibodies, Monoclonal; Antigens, Surface; Animals; Antibodies, Monoclonal/immunology; Antigens, Surface/analysis; Epithelium/pathology; Epithelium/radiation effects; Hematopoiesis/radiation effects; Leukemia, Radiation-Induced/immunology; Leukemia, Radiation-Induced/pathology; Mice; Mice, Inbred C57BL; Preleukemia/immunology; Preleukemia/pathology; Thymus Gland/immunology; Thymus Gland/pathology; Thymus Gland/radiation effects; lymphoepithelial interactions in vitro; Radiation-induced thymic lymphoma; thymic lymphopoiesis; thymic nurse cells; Hematology; Oncology; Cancer Research

Abstract :

[en] After a leukemogenic split dose course of irradiation, thymic nurse cells (TNCs) disappear. We have correlated this with the loss of an epithelial cell surface antigen (recognized by monoclonal antibody ER-TR3 and tentatively identified as Ia). In addition, epithelial cells have lost their capacity to interact with fetal thymocytes in vitro. Marrow grafting early after irradiation, that prevents the development of lymphomas, restores thymic nurse cells and thymocyte population. Such reconstitution and lymphoma prevention were not observed when marrow grafting was performed later (1 month after irradiation) during the preleukemic period.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences précliniques MI > Histologie - Cytologie

Rongy, A M; Laboratory of Pathological Anatomy, University of Liège, Belgium

Greimers, Roland ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques

Boniver, Jacques ; Université de Liège - ULiège > > Anatomie et cytologie pathologiques

Language :

English

Title :

Cellular aspects of radiation leukemogenesis in C57 BL/Ka mice: alterations to thymic microenvironment and lymphopoiesis.

Publication date :

1986

Journal title :

Leukemia Research

ISSN :

0145-2126

Publisher :

Elsevier BV, England

Volume :

Issue :

Pages :

783 - 789

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:0145212686902985?httpAccept=text/xml

Funders :

FRSM - Fonds de la Recherche Scientifique Médicale
CAC - Centre anticancéreux près l'Université de Liège asbl

Available on ORBi :

since 25 June 2023

Statistics

Number of views

42 (3 by ULiège)

Number of downloads

53 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Kaplan (1967) On the natural history of the murine leukemias: presidential address. Cancer Res. 27:1325.
Boniver, Houben-Defresne, Goffinet, Lenaerts, Betz (1985) Target cells and thymus micro-environment in the pathogenesis of thymic lymphomas in C57BL/Ka mice. Int. J. Rad. Onc. Biophysics 11:65.
Haran-Ghera (1973) Relationship between tumor cell and host in chemical carcinogenesis. Nature New Biology 240:84.
Goffinet, Houben-Defresne, Boniver (1983) Correlation of alkaline phosphatase activity to normal T-cell differentiation and to radiation leukemia virus-induced preleukemic cells in the C57 BL mouse thymus. Cancer Res. 43:5416.
Haran-Ghera (1976) Pathways in murine radiation leukemogenesis. Biology of Radiation Carcinogenesis , J.M. Jushas, R.W. Tennant, J.D. Regan, Raven Press, New York; 245.
Haran-Ghera (1978) Spontaneous and induced pre-leukemia cells in C57 BL/Ka mice: brief communication. J. natn. Cancer Inst. 60:707.
Haran-Ghera (1980) Potential leukemic cells among bone marrow cells of young AKR/J mice. Proc. natn. Acad. Sci. U.S.A. , 3rd Edn.; 77:2923.
Haran-Ghera (1977) Target cells involved in radiation and radiation leukemia virus leukemogenesis. Int. Symp. on Radiation-Induced Leukemogenesis and Related Viruses , 3rd Edn., J.F. Duplan, Inserm Symposium No. 4, Elsevier/North Holland Biomedical Press, Amsterdam; 79.
Haran-Ghera (1978) Dependent and autonomous phases during leukemogenesis. Leukemia Res. 2:11.
Haran-Ghera (1985) Prothymocytes as target cells of T-cell leukemogenesis in the mouse. Surv. Immun. Res. 4:19.
Boniver, Decleve, Lieberman, Honsik, Travis, Kaplan (1981) Marrow-thymus interaction during radiation leukemogenesis in C57 BL/Ka mice. Cancer Res. 41:390.
Houben Defresne, Boniver (1983) Thymic nurse cells account for the thymus dependency of preleukemic cells in mice after inoculation of radiation leukemia virus. Leukemia Res. 7:575.
Hays (1982) Bone marrow progenitor of AKR mice give rise to thymic lymphoma cells. Leukemia Res. 6:429.
Takeuchi, Kato, Hays (1984) Presence of prelymphoma cells in the bone marrow of the lymphomagenic virus treated AKR mouse. Cancer Res. 44:1008.
O'Donnell, Woller, Chu (1984) Stages in development of mink cell focus inducing (MCF) virus-accelerated leukemia in AKR mice. J. exp. Med. 160:914.
Haran-Ghera, Rubio, Leeb, Goldstein (1978) Characteristics of preleukemia cells induced in mice. Cellular Immunology 37:308.
Reisner, Sharon, Haran-Ghera (1980) Expression of peanut agglutinin receptors on virus-induced preleukemic cells in mice. Proc. natn. Acad. Sci. U.S.A. , 3rd Edn.; 77:2244.
Wekerle, Ketelsen (1980) Thymic nurse cells—Ia—bearing epithelium involved in T-lymphocyte differentiation?. Nature, Lond. 283:402.
Wekerle, Ketelsen, Ernst (1980) Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: Morphological and serological characterization , 3rd Edn., J. exp. Med.; 151:925.
Kyewski, Kaplan (1982) Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells. J. Immun. 128:2287.
Houben-Defresne, Varlet, Boniver (1984) Thymic nurse cells and thymic repopulation after whole body sublethal irradiation in mice. Thymus 6:324.
Houben-Defresne, Lenaerts, Greimers, Boniver (1984) Interactions lympho-épithéliales dans le thymus au cours du développement des lymphomes radio-induits chez la souris C57 BL. C. R. Séanc. Soc. Biol. 178:195.
Pazmino, McEwan, Ihle (1978) Radiation leukemia in C57 BL/6 mice. III. Correlation of altered expression of terminal deoxynucleotidyl transferase to induction of leukemia. J. exp. Med. 148:1338.
Declève, Lieberman, Boniver, Kaplan (1979) In-vivo infectivity of the fibrotropic C-type viral isolates from C5BL/Ka mice. Cancer Res. 39:4322.
Herzenberg (1978) Analysis and separation using the fluorescence activated cell sorter (FACS). Handbook of Experimental Immunology , D.M. Weired, 3rd Edn., Blackwell Scientific Publications, Oxford, D.M. Weired 2nd edn. Handbook of Experimental Immunology Vol. 2 1978 Blackwell Scientific Publications Oxford 22; 2:22.
Houben-Defresne, Varlet, Goffinet, Boniver (1982) Thymic nurse cells are the first site of virus replication after inoculation of the radiation leukemia virus. Leukemia Research 2:231.
Van Vliet, Melis, Van Ewijk (1984) Monoclonal antibodies to stromal cell types of the mouse thymus. Eur. J. Immun. 14:524.
Van Ewijk, Van Soest, Van den Engh (1981) Fluorescence analysis and anatomic distribution of mouse T-lymphocyte subsets defined by monoclonal antibodies to the antigens Thy-1, Lyt-1, Lyt-2 and T-200. J. Immun. 127:2594.
Bevan (1977) a radiation chimera, host H2 antigens determine immune responsiveness of donor cytotoxic cells. Nature, Lond. 269:417.
Zinkernagel, Callahan, Klen, Dennert (1977) Cytotoxic T-cells learn specificity for self H-2 during differentiation in the thymus. Nature 271:251.
Bach, Goldstein (1980) Newer concept of thymic hormones. Thymus 2:1.
Van Vliet, Melis, Van Ewijk (1984) Immunohistology of thymic nurse cells. Cell. Immun. 87:101.