Distribution of Lyt antigens on the surface of thymocytes associated with thymic macrophages and dendritic cells.

Antigens, Ly; Gold; Animals; Dendritic Cells/immunology; Female; Immunohistochemistry; Macrophages/immunology; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes/classification; T-Lymphocytes/immunology; Thymus Gland/cytology; Thymus Gland/immunology; Anatomy; Agricultural and Biological Sciences (all); General Agricultural and Biological Sciences; General Medicine

Abstract :

[en] Thymocyte subpopulations that are associated with macrophages and dendritic cells of the thymus in vivo were isolated from the thymuses of C57B1/6 mice, and their Lyt phenotypes were analyzed. Electron-microscopic examination of immunogold-labeled cells revealed that the thymic complexes formed by macrophages mainly contained Lyt-2-positive thymocytes, while Lyt-1-positive thymocytes were more frequently associated with dendritic cells. The characteristic distributions of Lyt antigens on the surface of thymocytes in regions of reciprocal contact with macrophages (Lyt-2-positive cells) and dendritic cells (Lyt-1-positive cells) suggest that these antigens play a role in specific interactions between thymocytes and stroma cells.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Brelińska, R.; Medical Academy, Poznań, Poland > Department of Histology and Embryology

Warchoł, J.B.; Medical Academy, Poznań, Poland > Department of Histology and Embryology

Boniver, Jacques ; Université de Liège - ULiège > Département des sciences précliniques MI > Anatomie et cytologie pathologiques

Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences précliniques MI > Anatomie et cytologie pathologiques

Language :

English

Title :

Distribution of Lyt antigens on the surface of thymocytes associated with thymic macrophages and dendritic cells.

Publication date :

1988

Journal title :

Histochemistry

ISSN :

0301-5564

Publisher :

Springer-Verlag, Germany

Volume :

Issue :

3-6

Pages :

553 - 556

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://link.springer.com/content/pdf/10.1007/BF00570323.pdf

Funders :

FRSM - Fonds de la Recherche Scientifique Médicale
CAC - Centre anticancéreux près l'Université de Liège asbl

Available on ORBi :

since 25 May 2023

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