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Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease
Moallemian, Soodeh; Salmon, Eric; Bahri, Mohamed Ali et al.
2023
 

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Keywords :
Alzheimer's disease (AD); quantitative MRI (qMRI); multivariate General Linear Model (mGLM)
Abstract :
[en] Multiple neuropathological changes are involved in Alzheimer's disease (AD). AD hallmark biomarkers are amyloid-beta, tau pathology, and neuronal and synaptic loss. Other possible brain tissue-related biomarkers, such as iron and myelin content in the brain, are less frequently studied. Thanks to quantitative MRI (qMRI), tissue parameters such as magnetization transfer (MT), effective transverse relaxation (R2*), and proton density (PD) can be determined quantitatively, enabling the detection of microstructural tissue-related alterations in aging and neurodegenerative diseases. The current study investigated the co-occurrence of neurodegeneration (as measured with synaptic density), increased iron content, and decreased myelin content in Alzheimer's disease. The study involved 24 amyloid-positive patients (AD, 11 males) and 19 healthy controls (HC, 9 males). All participants underwent a multi-parameter mapping MRI protocol, from which quantitative maps for MTsat and R2* were estimated. Synaptic density was indexed by the total volume distribution map (Vt) derived from [18F] UCB-H PET imaging. First, groups were compared with univariate statistical analyses applied to R2*, MTsat, and Vt maps. Then multivariate General Linear Model (mGLM) was used to detect the co-occurrence of changes in R2*, MTsat, and Vt at the voxel level. Univariate GLM analysis of R2* showed no significant difference between the two groups. In contrast, the same analysis for MTsat resulted in a significant between-group difference in the right hippocampus at the cluster level with a corrected threshold (P-value < .05). The mGLM analysis revealed a significant difference in both right and left hippocampus between the AD and HC groups, as well as in the left precuneus, right middle frontal, and left superior orbitofrontal gyrus when all three modalities were present, suggesting these regions as the most affected despite the diverse changes of myelin, iron, and synapse degeneration in AD. Here, the mGLM is introduced as an alternative for multiple comparisons between different modalities, as it reduces the risk of false positives due to the multiplicity of the tests while informing about the co-occurrence of neuropathological processes in dementia.
Disciplines :
Radiology, nuclear medicine & imaging
Neurology
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Moallemian, Soodeh  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Salmon, Eric  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Beliy, Nikita ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Delhaye, Emma  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Balteau, Evelyne ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Degueldre, Christian ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Phillips, Christophe   ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Bastin, Christine   ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
 These authors have contributed equally to this work.
Language :
English
Title :
Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease
Publication date :
17 April 2023
Source :
Funders :
Walloon region [BE]
F.R.S.-FNRS - Fund for Scientific Research [BE]
Funding text :
This research was supported by the Walloon Region in the framework of the PIT program PROTHER-WAL under grant agreement No. 7289
Available on ORBi :
since 21 May 2023

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