Article (Scientific journals)
Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study
Vandeleene, Nora; Guillemin, Camille; Dauby, Solène et al.
2023In Brain and Behavior
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Keywords :
longitudinal analysis; multiple sclerosis; quantitative MRI; relaxometry
Abstract :
[en] Introduction: Quantitative MRI quantifies tissue microstructural properties and supports the characterization of cerebral tissue damages. With an MPM protocol, 4 parameter maps are constructed: MTsat, PD, R1 and R2*, reflecting tissue physical properties associated with iron and myelin contents. Thus, qMRI is a good candidate for in vivo monitoring of cerebral damage and repair mechanisms related to MS. Here, we used qMRI to investigate the longitudinal microstructural changes in MS brain. Methods: Seventeen MS patients (age 25-65, 11 RRMS) were scanned on a 3T MRI, in two sessions separated with a median of 30 months, and the parameters evolution was evaluated within several tissue classes: NAWM, NACGM and NADGM, as well as focal WM lesions. An individual annual rate of change for each qMRI parameter was computed, and its correlation to clinical status was evaluated. For WM plaques, three areas were defined, and a GLMM tested the effect of area, time points, and their interaction on each median qMRI parameter value. Results: Patients with a better clinical evolution, that is, clinically stable or improving state, showed positive annual rate of change in MTsat and R2* within NAWM and NACGM, suggesting repair mechanisms in terms of increased myelin content and/or axonal density as well as edema/inflammation resorption. When examining WM lesions, qMRI parameters within surrounding NAWM showed microstructural modifications, even before any focal lesion is visible on conventional FLAIR MRI. Conclusion: The results illustrate the benefit of multiple qMRI data in monitoring subtle changes within normal appearing brain tissues and plaque dynamics in relation with tissue repair or disease progression. Emilie Lommers and Christophe Phillips equally contributed to the work.
Disciplines :
Neurology
Radiology, nuclear medicine & imaging
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Vandeleene, Nora  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Guillemin, Camille ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog)
Dauby, Solène  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Requier, Florence  ;  Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Charonitis, Maëlle  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Chylinski, Daphné ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Balteau, Evelyne ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Lommers, Emilie   ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Phillips, Christophe   ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
 These authors have contributed equally to this work.
Language :
English
Title :
Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study
Publication date :
April 2023
Journal title :
Brain and Behavior
eISSN :
2162-3279
Publisher :
Wiley-Blackwell, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 May 2023

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