antimicrobial resistance; immunomodulation; gut microbiota; bacteriocins; human health; animal health
Abstract :
[en] Probiotics are live microorganisms recognized as natural candidates to substitute antibiotic substances, usually used to treat bacterial infections responsible for numerous human and animal diseases. Antibiotics are mostly prescribed for treating infections caused by bacteria. However, their excessive and inappropriate use has resulted in the increase of bacterial antimicrobial resistance (AMR) and host microbiota imbalance or dysbiosis phenomena. Even though antibiotics are the most well-known lifesaving substances, the AMR within the bacterial community has become a growing threat to global health, with the potential to cause millions of deaths each year in the future. Faced with these worldwide issues, it is high time to discover and develop antibiotic alternatives. There exists some evidence of probiotic roles in antagonizing pathogens, modulating immune systems, and maintaining general host health by restoring the gut microbiota balance. The multi-antimicrobial action mechanisms of such beneficial living microorganisms are one approach to practicing the “prevention is better than cure” concept to avoid antibiotics. The current review proposes a comprehensive description of antibiotic-related AMR issues and the potential of probiotics as antibiotic alternatives, while discussing pros and cons, as well as some evidence of beneficial uses of probiotics for human and animal health protection through recent results of experimental models and clinical trials.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Rabetafika, Holy
Razafindralambo Aurélie
Bassey Ebenso
Razafindralambo, Hary ; Université de Liège - ULiège > Département GxABT > Microbial technologies
Language :
English
Title :
Probiotics as Antibiotic Alternatives for Human and Animal Applications
Publication date :
30 April 2023
Journal title :
Encyclopedia
eISSN :
2673-8392
Publisher :
MDPI, Basel, Switzerland
Volume :
3
Issue :
2
Pages :
561-581
Peer reviewed :
Peer Reviewed verified by ORBi
Development Goals :
3. Good health and well-being 12. Responsible consumption and production 14. Life below water 15. Life on land