Efficacy of the Adjunct Use of Povidone-Iodine or Sodium Hypochlorite with Non-Surgical Management of Periodontitis: A Systematic Review and Meta-Analysis.
NaOCl; PVP-I; non-surgical; periodontal therapy; periodontitis; povidone-iodine; sodium hypochlorite; Medicine (all); General Medicine
Abstract :
[en] This systematic review sought to assess the efficacy of combining either sodium hypochlorite or povidone-iodine as disinfection solutions with non-surgical treatment of periodontitis. An electronic search was conducted through PubMed, Scopus, Web of Science, CENTRAL, and Google Scholar from inception until 10 September 2022. Outcomes included clinical outcomes (probing pocket depth, plaque index, clinical attachment level, relative-horizontal attachment level, bleeding on probing, gingival recession, the position of gingival margin) and biochemical (BAPNA level) properties. A subgroup analysis was conducted according to the assessment timepoint. Ten studies reporting the use of povidone-iodine and five studies reporting the use of sodium hypochlorite were included in this review. Overall, in the meta-analysis of povidone-iodine, no significant changes were noted in any of the assessed outcomes; however, minor changes were noted in probing pocket depth and clinical attachment level at a specific timepoint. Regarding sodium hypochlorite, a significant reduction in all clinical outcomes, except for bleeding on probing, was noted. In conclusion, the use of povidone-iodine does not result in an improvement in clinical outcomes, whereas sodium hypochlorite has promising properties that result in significant improvement in probing pocket depth and clinical attachment level. However, more studies are needed to confirm these observations.
Disciplines :
Dentistry & oral medicine
Author, co-author :
El Mobadder, Marwan ; Dental Surgery Department, Wroclaw Medical University, 50-425 Wroclaw, Poland
Namour, Samir ; Université de Liège - ULiège > Département des sciences dentaires
Grzech-Leśniak, Zuzanna; Dental Surgery Department, Wroclaw Medical University, 50-425 Wroclaw, Poland
Grzech-Leśniak, Kinga ; Dental Surgery Department, Wroclaw Medical University, 50-425 Wroclaw, Poland
Language :
English
Title :
Efficacy of the Adjunct Use of Povidone-Iodine or Sodium Hypochlorite with Non-Surgical Management of Periodontitis: A Systematic Review and Meta-Analysis.
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Bibliography
Orlandi M. Muñoz Aguilera E. Marletta D. Petrie A. Suvan J. D’Aiuto F. Impact of the treatment of periodontitis on systemic health and quality of life: A systematic review J. Clin. Periodontol. 2022 49 314 327 10.1111/jcpe.13554 34791686
Hajishengallis G. Darveau R.P. Curtis M.A. The keystone-pathogen hypothesis Nat. Rev. Microbiol. 2012 10 717 725 10.1038/nrmicro2873 22941505
Tan Q. Ma X. Yang B. Liu Y. Xie Y. Wang X. Yuan W. Ma J. Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils Gut Microbes 2022 14 2073785 10.1080/19490976.2022.2073785
Holt S.C. Ebersole J. Felton J. Brunsvold M. Kornman K.S. Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis Science 1988 239 55 57 10.1126/science.3336774 3336774
Sbordone L. Bortolaia C. Oral microbial biofilms and plaque-related diseases: Microbial communities and their role in the shift from oral health to disease Clin. Oral Investig. 2003 7 181 188 10.1007/s00784-003-0236-1
Sanz M. Herrera D. Kebschull M. Chapple I. Jepsen S. Beglundh T. Sculean A. Tonetti M.S. Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline J. Clin. Periodontol. 2020 47 4 60 10.1111/jcpe.13290
Armitage G.C. Cullinan M.P. Comparison of the clinical features of chronic and aggressive periodontitis Periodontology 2000 2010 53 12 27 10.1111/j.1600-0757.2010.00353.x
Murphy K.G. Gunsolley J.C. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review Ann. Periodontol. 2003 8 266 302 10.1902/annals.2003.8.1.266
Kebschull M. Chapple I. Evidence-based, personalised and minimally invasive treatment for periodontitis patients—The new EFP S3-level clinical treatment guidelines Br. Dent. J. 2020 229 443 449 10.1038/s41415-020-2173-7
Cho-Yan Lee J. Mattheos N. Nixon K.C. Ivanovski S. Residual periodontal pockets are a risk indicator for peri-implantitis in patients treated for periodontitis Clin. Oral Implant. Res. 2012 23 325 333 10.1111/j.1600-0501.2011.02264.x 22092508
Deas D.E. Moritz A.J. Sagun R.S. Jr. Gruwell S.F. Powell C.A. Scaling and root planing vs. conservative surgery in the treatment of chronic periodontitis Periodontology 2000 2016 71 128 139 10.1111/prd.12114 27045434
Graziani F. Karapetsa D. Mardas N. Leow N. Donos N. Surgical treatment of the residual periodontal pocket Periodontology 2000 2018 76 150 163 10.1111/prd.12156 29193404
Gonçalves L.S. Rodrigues R.C. Andrade Junior C.V. Soares R.G. Vettore M.V. The Effect of Sodium Hypochlorite and Chlorhexidine as Irrigant Solutions for Root Canal Disinfection: A Systematic Review of Clinical Trials J. Endod. 2016 42 527 532 10.1016/j.joen.2015.12.021
Gorr S.U. Abdolhosseini M. Antimicrobial peptides and periodontal disease J. Clin. Periodontol. 2011 38 126 141 10.1111/j.1600-051X.2010.01664.x
Li S. Schmalz G. Schmidt J. Krause F. Haak R. Ziebolz D. Antimicrobial peptides as a possible interlink between periodontal diseases and its risk factors: A systematic review J. Periodontal Res. 2018 53 145 155 10.1111/jre.12482
Martin-Cabezas R. Davideau J.L. Tenenbaum H. Huck O. Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: A systematic review and meta-analysis J. Clin. Periodontol. 2016 43 520 530 10.1111/jcpe.12545
Mulhall H. DiChiara J.M. Deragon M. Iyer R. Huck O. Amar S. Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis Infect. Immun. 2020 89 10.1128/IAI.00500-20
Grzech-Leśniak K. Making Use of Lasers in Periodontal Treatment: A New Gold Standard? Photomed. Laser Surg. 2017 10 513 514 10.1089/pho.2017.4323
Gonzalez S. Cohen C.L. Galván M. Alonaizan F.A. Rich S.K. Slots J. Gingival bleeding on probing: Relationship to change in periodontal pocket depth and effect of sodium hypochlorite oral rinse J. Periodontal Res. 2015 50 397 402 10.1111/jre.12219
Chang Y.C. Huang F.M. Tai K.W. Chou M.Y. The effect of sodium hypochlorite and chlorhexidine on cultured human periodontal ligament cells Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2001 92 446 450 10.1067/moe.2001.116812 11598582
De Nardo R. Chiappe V. Gómez M. Romanelli H. Slots J. Effects of 0.05% sodium hypochlorite oral rinse on supragingival biofilm and gingival inflammation Int. Dent. J. 2012 62 208 212 10.1111/j.1875-595X.2011.00111.x 23017003
Galván M. Gonzalez S. Cohen C.L. Alonaizan F.A. Chen C.T. Rich S.K. Slots J. Periodontal effects of 0.25% sodium hypochlorite twice-weekly oral rinse. A pilot study J. Periodontal Res. 2014 49 696 702 10.1111/jre.12151 24329929
Jurczyk K. Nietzsche S. Ender C. Sculean A. Eick S. In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis Clin. Oral Investig. 2016 20 2165 2173 10.1007/s00784-016-1711-9 26759339
Ramanauskaite E. Machiulskiene V. Eliezer M. Sculean A. Sodium Hypochlorite as an Adjunct to Nonsurgical Treatment of Periodontitis: A Systematic Review Oral Health Prev. Dent. 2020 18 881 887 10.3290/j.ohpd.a45405 33215480
Gambarini G. De Luca M. Gerosa R. Chemical stability of heated sodium hypochlorite endodontic irrigants J. Endod. 1998 24 432 434 10.1016/S0099-2399(98)80027-7
Sirtes G. Waltimo T. Schaetzle M. Zehnder M. The effects of temperature on sodium hypochlorite short-term stability, pulp dissolution capacity, and antimicrobial efficacy J. Endod. 2005 31 669 671 10.1097/01.don.0000153846.62144.d2
Forabosco A. Spinato S. Grandi T. Prini M. A comparative study between different techniques in non-surgical periodontal treatment Minerva Stomatol. 2006 55 289 296
Hoang T. Jorgensen M.G. Keim R.G. Pattison A.M. Slots J. Povidone-iodine as a periodontal pocket disinfectant J. Periodontal Res. 2003 38 311 317 10.1034/j.1600-0765.2003.02016.x
Rosling B. Hellström M.K. Ramberg P. Socransky S.S. Lindhe J. The use of PVP-iodine as an adjunct to non-surgical treatment of chronic periodontitis J. Clin. Periodontol. 2001 28 1023 1031 10.1034/j.1600-051X.2001.281106.x
Del Peloso Ribeiro E. Bittencourt S. Ambrosano G.M. Nociti F.H. Jr. Sallum E.A. Sallum A.W. Casati M.Z. Povidone-iodine used as an adjunct to non-surgical treatment of furcation involvements J. Periodontol. 2006 77 211 217 10.1902/jop.2006.050095 16460246
Koshy G. Kawashima Y. Kiji M. Nitta H. Umeda M. Nagasawa T. Ishikawa I. Effects of single-visit full-mouth ultrasonic debridement versus quadrant-wise ultrasonic debridement J. Clin. Periodontol. 2005 32 734 743 10.1111/j.1600-051X.2005.00775.x
Leonhardt A. Bergström C. Krok L. Cardaropoli G. Healing following ultrasonic debridement and PVP-iodine in individuals with severe chronic periodontal disease: A randomized, controlled clinical study Acta Odontol. Scand. 2006 64 262 266 10.1080/00016350600613625 16945890
Zanatta G.M. Bittencourt S. Nociti F.H. Jr. Sallum E.A. Sallum A.W. Casati M.Z. Periodontal debridement with povidone-iodine in periodontal treatment: Short-term clinical and biochemical observations J. Periodontol. 2006 77 498 505 10.1902/jop.2006.050154 16512765
Muka T. Glisic M. Milic J. Verhoog S. Bohlius J. Bramer W. Chowdhury R. Franco O.H. A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research Eur. J. Epidemiol. 2020 35 49 60 10.1007/s10654-019-00576-5
Forgas L.B. Gound S. The effects of antiformin-citric acid chemical curettage on the microbial flora of the periodontal pocket J. Periodontol. 1987 58 153 158 10.1902/jop.1987.58.3.153
Megally A. Zekeridou A. Cancela J. Giannopoulou C. Mombelli A. Short ultrasonic debridement with adjunctive low-concentrated hypochlorite/amino acid gel during periodontal maintenance: Randomized clinical trial of 12 months Clin. Oral Investig. 2020 24 201 209 10.1007/s00784-019-02949-2
Al-Saeed M.Y. Babay N. The use of povidone-iodine and hydrogen peroxide mixture as an adjunct to non-surgical treatment of slight to moderate chronic periodontitis Saudi Dent. J. 2009 21 127 133 10.1016/j.sdentj.2009.10.004
Bizzarro S. Van der Velden U. Loos B.G. Local disinfection with sodium hypochlorite as adjunct to basic periodontal therapy: A randomized controlled trial J. Clin. Periodontol. 2016 43 778 788 10.1111/jcpe.12578
Do Vale H.F. Casarin R.C. Taiete T. Bovi Ambrosano G.M. Ruiz K.G. Nociti F.H. Jr. Sallum E.A. Casati M.Z. Full-mouth ultrasonic debridement associated with povidone iodine rinsing in GAgP treatment: A randomised clinical trial Clin. Oral Investig. 2016 20 141 150 10.1007/s00784-015-1471-y
Iorio-Siciliano V. Ramaglia L. Isola G. Blasi A. Salvi G.E. Sculean A. Changes in clinical parameters following adjunctive local sodium hypochlorite gel in minimally invasive nonsurgical therapy (MINST) of periodontal pockets: A 6-month randomized controlled clinical trial Clin. Oral Investig. 2021 25 5331 5340 10.1007/s00784-021-03841-8 33687555
Kessler S. Lasserre J. Toma S. Evaluation of multiple subgingival irrigations with 10% povidone-iodine after scaling and root planing: A randomized clinical trial Quintessence Int. 2021 52 496 504 10.3290/j.qi.b1044059 33688714
Krück C. Eick S. Knöfler G.U. Purschwitz R.E. Jentsch H.F. Clinical and microbiologic results 12 months after scaling and root planing with different irrigation solutions in patients with moderate chronic periodontitis: A pilot randomized trial J. Periodontol. 2012 83 312 320 10.1902/jop.2011.110044 21749169
Perrella F.A. Rovai E.D.S. De Marco A.C. Santamaria M.P. Feres M. de Figueredo L.C. Kerbauy W.D. Amorim J.B.O. Clinical and Microbiological Evaluation of Povidone-Iodine 10% as an Adjunct to Nonsurgical Periodontal Therapy in Chronic Periodontitis: A Randomized Clinical Trial J. Int. Acad. Periodontol. 2016 18 109 119
Radulescu V. Boariu M.I. Rusu D. Roman A. Surlin P. Voicu A. Didilescu A.C. Jentsch H. Siciliano V.I. Ramaglia L. et al. Clinical and microbiological effects of a single application of sodium hypochlorite gel during subgingival re-instrumentation: A triple-blind randomized placebo-controlled clinical trial Clin. Oral Investig. 2022 10.1007/s00784-022-04618-3
Ribeiro Edel P. Bittencourt S. Sallum E.A. Sallum A.W. Nociti F.H. Jr. Casati M.Z. Non-surgical instrumentation associated with povidone-iodine in the treatment of interproximal furcation involvements J. Appl. Oral Sci. Rev. FOB 2010 18 599 606 10.1590/S1678-77572010000600011
Sahrmann P. Imfeld T. Ronay V. Attin T. Schmidlin P.R. Povidone-iodine gel and solution as adjunct to ultrasonic debridement in nonsurgical periodontitis treatment: An RCT pilot study Quintessence Int. 2014 45 281 290 10.3290/j.qi.a31341
Estrela C. Estrela C.R. Barbin E.L. Spanó J.C. Marchesan M.A. Pécora J.D. Mechanism of action of sodium hypochlorite Braz. Dent. J. 2002 13 113 117 10.1590/S0103-64402002000200007
Van der Weijden G. Hioe K. A systematic review of the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush J. Clin. Periodontol. 2005 32 214 228 10.1111/j.1600-051X.2005.00795.x
Estrela C. Sydney G.B. Bammann L.L. Felippe Junior O. Estudo do efeito biológico do pH na atividade de enzimática de bacterias anaeróbicas Rev. Fac. Odontol. Bauru 1994 2 31 38
Sahrmann P. Puhan M.A. Attin T. Schmidlin P.R. Systematic review on the effect of rinsing with povidone-iodine during nonsurgical periodontal therapy J. Periodontal Res. 2010 45 153 164 10.1111/j.1600-0765.2009.01232.x 19909406
Sahm N. Becker J. Santel T. Schwarz F. Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: A prospective, randomized, controlled clinical study J. Clin. Periodontol. 2011 38 872 878 10.1111/j.1600-051X.2011.01762.x 21770995
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