[en] Introduction: Hippocampal local and network dysfunction is the hallmark of Alzheimer’s disease (AD).
Methods: We characterized the spatial patterns of hippocampus differentiation based on brain co-metabolism in healthy older participants and demonstrated their relevance to study local metabolic changes and associated dysfunction in pathological aging.
Results: The hippocampus can be differentiated into anterior/posterior and dorsal (CA)/ventral (subiculum) subregions. While anterior and posterior CA show co-metabolism with different regions of the subcortical limbic networks, the anterior and posterior subiculum are parts of cortical networks supporting object-centered memory and higher cognitive demands, respectively. Both networks show relationships with the spatial patterns of gene expression pertaining to cell energy metabolism and AD’s process. Finally, while local metabolism is generally lower in posterior regions, the anterior-posterior imbalance is maximal in late MCI with the anterior subiculum being relatively preserved.
Discussion: Future studies should consider bidimensional hippocampal differentiation and in particular the posterior subicular region for better understanding pathological aging.
Disciplines :
Neurosciences & behavior
Author, co-author :
Maleki Balajoo, Somayeh
Eickhoff, Simon B.
Kharabian Masouleh, Shahrzad
Plachti, Anna
Waite, Laura
Saberi, Amin
Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Bastin, Christine ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Hoffstaedter, Felix
Palomero-Gallagher, Nicola
Genon, Sarah ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.
Language :
English
Title :
Hippocampal metabolic subregions and networks: Behavioral, molecular and pathological aging profiles
Publication date :
2023
Journal title :
Alzheimer's and Dementia: the Journal of the Alzheimer's Association
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