Article (Scientific journals)
Airflow obstruction as a marker of adverse prognosis in rheumatoid arthritis
Guiot, Julien; Henket, Monique; Ernst, Marie et al.
2023In Frontiers in Medicine, 10
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Keywords :
General Medicine
Abstract :
[en] ObjectivesIn our study, we explored the specific subgroup of patients with rheumatoid arthritis (RA) suffering from obstructive lung disease (OLD) and its impact on morbi-mortality.MethodsOur retrospective study included 309 patients suffering from RA with either obstructive (O-RA) or non-obstructive patterns (non-O-RA). OLD was defined based on the Tiffeneau index at the first available pulmonary functional test (PFT). Survival was then calculated and represented by a Kaplan–Meier curve. The comparison between the populations considered was performed by the Log-Rank test.ResultsOut of the 309 RA patients, 102 (33%) had airway obstruction. The overall survival time was significantly lower in the O-RA group than in the non-O-RA group (n = 207) (p < 0.001). The median survival time was 11.75 years in the O-RA group and higher than 16 years in the non-O-RA group. Multivariate analysis identified OLD as an independent risk factor for mortality (HR 2.20; 95% CI 1.21–4.00, p < 0.01).ConclusionAirway obstruction can be an independent risk factor of mortality in RA and should be considered as an early marker of poor prognosis. Further prospective longitudinal studies are required in order to determine the best clinical management for O-RA patients.
Disciplines :
Cardiovascular & respiratory systems
Rheumatology
Author, co-author :
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Henket, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Ernst, Marie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Seidel, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
WINANDY, Marie-Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de pneumologie - allergologie
DENIS, Anna ;  Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants
Frix, Anne-Noëlle ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
GESTER, Fanny ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
THYS, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
GILTAY, Laurie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Garah, Omaïma ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Njock, Makon-Sébastien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
CANIVET, Perrine ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Meunier, Paul ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Corhay, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Regnier, Céline ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Malaise, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Malaise, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de rhumatologie
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
More authors (9 more) Less
Language :
English
Title :
Airflow obstruction as a marker of adverse prognosis in rheumatoid arthritis
Publication date :
09 March 2023
Journal title :
Frontiers in Medicine
eISSN :
2296-858X
Publisher :
Frontiers Media SA
Volume :
10
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 March 2023

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