Article (Scientific journals)
The Dual Function of RhoGDI2 in Immunity and Cancer
Tripathi, Mudrika; Colige, Alain; Deroanne, Christophe
2023In International Journal of Molecular Sciences, 24 (4), p. 4015
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Keywords :
Molecular Biology; RhoGDI1; RhoGDI2; RhoGTPases; Cancer
Abstract :
[en] RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is also present in a large array of other cell types. RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it can display a dual role. Despite its involvement in various biological processes, we still do not have a clear understanding of its mechanistic functions. This review sheds a light on the dual opposite role of RhoGDI2 in cancer, highlights its underappreciated role in immunity and proposes ways to explain its intricate regulatory functions.
Research center :
GIGA-LCTB - GIGA Cancer-Connective Tissue Biology - ULiège
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Tripathi, Mudrika  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Connective Tissue Biology
Colige, Alain ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Connective Tissue Biology
Deroanne, Christophe ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Connective Tissue Biology
Language :
English
Title :
The Dual Function of RhoGDI2 in Immunity and Cancer
Publication date :
16 February 2023
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
MDPI AG
Special issue title :
Mechanical and Biochemical Interplay between Cells and Their Microenvironment
Volume :
24
Issue :
4
Pages :
4015
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Deciphering the RhoGDI2-specific protein interaction network and dynamics to understand its dual function in cancer.
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Funding number :
Télévie Grant No. 7.6533.21
Available on ORBi :
since 20 February 2023

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