Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics.

[en] ("[en] PURPOSE: Asthma negatively impacts health-related quality of life (HRQL). The objective is to investigate the longitudinal relationship between HRQL in asthma and disease control, demographic and clinical objective parameters in an adult population in real-life settings. METHODS: We conducted a longitudinal study on adult asthmatics recruited from Liege University Hospital Asthma Clinic (Belgium) between 2011 and 2019. We selected those who had two visits and completed two patient-reported outcome measures (PROMs), the asthma control test (ACT) and the mini asthma quality of life questionnaire (AQLQ) (n = 290). AQLQ was the dependent variable. Demographic, functional and inflammatory characteristics, asthma control, and exacerbations were the independent variables. We applied generalized linear mixed models to identify the factors associated with change in AQLQ and its dimensions. RESULTS: Median (IQR) time interval between the two visits was 7 (5-19) months. Overall, median (IQR) global AQLQ increased from 4.1 (3-5.1) to 4.6 (3.4-5.9) (p < 0.0001). All AQLQ dimensions significantly improved, apart the environmental one. AQLQ improved in patients who had both step-up and step-down pharmacological treatment as well as in patients reporting no change between the two visits. The fitted models indicated that change in ACT was the main predictor of change in AQLQ (p < 0.0001). A rise in 3 units in ACT predicted an improvement of 0.5 AQLQ (AUC-ROC = 0.85; p < 0.0001). Change in BMI inversely impacted global AQLQ (p < 0.01) and its activity dimension (p < 0.0001). CONCLUSION: Asthma control and BMI are key predictors of asthma quality of life acting in an opposite direction. AQLQ may improve without step-up in the pharmacological treatment.","[en] ","")

Disciplines :

Public health, health care sciences & services

Author, co-author :

Louis, Gilles ; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé

Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés

Schleich, FLorence ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Zahrei, Halehsadat Nekoee; Department of Public Health, Biostatistics Unit, University of Liège, Liège, Belgium

Donneau, Anne-Françoise ; Université de Liège - ULiège > Département des sciences de la santé publique

Henket, Monique ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

PAULUS, Virginie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

GUISSARD, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Guillaume, Michèle ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques

Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Language :

English

Title :

Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics.

Publication date :

03 January 2023

Journal title :

Quality of Life Research

ISSN :

0962-9343

eISSN :

1573-2649

Publisher :

Springer Science and Business Media LLC, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/content/pdf/10.1007/s11136-022-03339-0.pdf

Funders :

BELSPO - Belgian Science Policy Office [BE]
Interreg

Available on ORBi :

since 06 February 2023

Statistics

Number of views

95 (28 by ULiège)

Number of downloads

34 (6 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

Bibliography

Soriano, J. B., Abajobir, A. A., Abate, K. H., et al. (2017). Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet Respiratory Medicine, 5(9), 691–706. 10.1016/S2213-2600(17)30293-X DOI: 10.1016/S2213-2600(17)30293-X
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION Updated 2020. 2020. www.ginasthma.org. Accessed August 21, 2020.
Ford, E. S., Mannino, D. M., Homa, D. M., et al. (2003). Self-reported asthma and health-related quality of life: Findings from the behavioral risk factor surveillance system. Chest, 123(1), 119–127. 10.1378/chest.123.1.119 DOI: 10.1378/chest.123.1.119
Sullivan, P. W., Smith, K. L., Ghushchyan, V. H., Globe, D. R., Lin, S. L., & Globe, G. (2013). Asthma in USA: Its impact on health-related quality of life. Journal of Asthma, 50(8), 891–899. 10.3109/02770903.2013.813035 DOI: 10.3109/02770903.2013.813035
Louis, G., Pétré, B., Charlier, N., Voz, B., & Guillaume, M. (2021). Quality of life in the medical field: A brief overview of its origin, semantics, measuring instruments and clinical use. Revue Medicale Liege, 76(9), 689–696.
Gonzalez-Barcala, F. J., De La Fuente-Cid, R., Tafalla, M., Nuevo, J., & Caamaño-Isorna, F. (2012). Factors associated with health-related quality of life in adults with asthma. A cross-sectional study. Multidisciplinary Respiratory Medicine. 10.1186/2049-6958-7-32 DOI: 10.1186/2049-6958-7-32
Juniper, E. F., Wisniewski, M. E., Cox, F. M., Emmett, A. H., Nielsen, K. E., & O’Byrne, P. M. (2004). Relationship between quality of life and clinical status in asthma: A factor analysis. European Respiratory Journal, 23(2), 287–291. 10.1183/09031936.04.00064204 DOI: 10.1183/09031936.04.00064204
National Asthma Education and Prevention Program TEP on the D and M of A. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. 2007. https://www.ncbi.nlm.nih.gov/books/NBK7232/. Accessed September 9, 2021.
Ford, E. S., Mannino, D. M., Redd, S. C., Moriarty, D. G., & Mokdad, A. H. (2004). Determinants of quality of life among people with asthma: Findings from the behavioral risk factor surveillance system. Journal of Asthma, 41(3), 327–336. 10.1081/jas-120026090 DOI: 10.1081/jas-120026090
Böhmer, M. M., Brandl, M., Brandstetter, S., et al. (2017). Factors associated with generic health-related quality of life in adult asthma patients in Germany: Cross-sectional study. Journal of Asthma, 54(3), 325–334. 10.1080/02770903.2016.1206563 DOI: 10.1080/02770903.2016.1206563
Louis, G., Pétré, B., Schleich, F., et al. (2021). Predictors of asthma-related quality of life in a large cohort of asthmatics: A cross-sectional study in a secondary care center. Clinical and Translational Allergy. 10.1002/clt2.12054 DOI: 10.1002/clt2.12054
Naleway, A. L., Vollmer, W. M., Frazier, E. A., O’Connor, E., & Magid, D. J. (2006). Gender Differences in Asthma Management and Quality of Life. Journal of Asthma, 43(7), 549–552. 10.1080/02770900600858992 DOI: 10.1080/02770900600858992
Leander, M., Lampa, E., Janson, C., Svrdsudd, K., Uddenfeldt, M., & Rask-Andersen, A. (2012). Determinants for a low health-related quality of life in asthmatics. Upsala journal of medical sciences, 117(1), 57–66. 10.3109/03009734.2011.638730 DOI: 10.3109/03009734.2011.638730
Lavoie, K. L., Bacon, S. L., Labrecque, M., Cartier, A., & Ditto, B. (2006). Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respiratory Medicine, 100(4), 648–657. 10.1016/j.rmed.2005.08.001 DOI: 10.1016/j.rmed.2005.08.001
Leidy, N. K., & Coughlin, C. (1998). Psychometric performance of the Asthma Quality of Life Questionnaire in a US sample. Quality of Life Research, 7(2), 127–134. 10.1023/A:1008853325724 DOI: 10.1023/A:1008853325724
Uchmanowicz, B., Panaszek, B., Uchmanowicz, I., & Rosińczuk, J. (2016). Sociodemographic factors affecting the quality of life of patients with asthma. Patient Preference and Adherence, 10, 345–354. 10.2147/PPA.S101898 DOI: 10.2147/PPA.S101898
Upton, J., Lewis, C., Humphreys, E., Price, D., & Walker, S. (2016). Asthma-specific health-related quality of life of people in Great Britain: A national survey. Journal of Asthma, 53(9), 975–982. 10.3109/02770903.2016.1166383 DOI: 10.3109/02770903.2016.1166383
Ehrs, P. O., Sundblad, B. M., & Larsson, K. (2006). Quality of life and inflammatory markers in mild asthma. Chest, 129(3), 624–631. 10.1378/chest.129.3.624 DOI: 10.1378/chest.129.3.624
Caminati, M., Vianello, A., Chieco Bianchi, F., et al. (2020). Relevance of TH2 markers in the assessment and therapeutic management of severe allergic asthma: A real-life perspective. Journal of Investigational Allergology and Clinical Immunology, 30(1), 35–41. 10.18176/jiaci.0379 DOI: 10.18176/jiaci.0379
Orr, L. C., Fowler, S. J., & Lipworth, B. J. (2003). Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma. American Journal of Respiratory Medicine, 2(5), 433–438. 10.1007/BF03256669 DOI: 10.1007/BF03256669
Carranza Rosenzweig, J. R., Edwards, L., Lincourt, W., Dorinsky, P., & ZuWallack, R. L. (2004). The relationship between health-related quality of life, lung function and daily symptoms in patients with persistent asthma. Respiratory Medicine, 98(12), 1157–1165. 10.1016/j.rmed.2004.04.001 DOI: 10.1016/j.rmed.2004.04.001
Demarche, S., Schleich, F., Henket, M., Paulus, V., Louis, R., & Van Hees, T. (2018). Step-down of inhaled corticosteroids in non-eosinophilic asthma: A prospective trial in real life. Clinical and Experimental Allergy, 48(5), 525–535. 10.1111/cea.13106 DOI: 10.1111/cea.13106
Nathan, R. A., Sorkness, C. A., Kosinski, M., et al. (2004). Development of the asthma control test: A survey for assessing asthma control. The Journal of Allergy and Clinical Immunology, 113(1), 59–65. 10.1016/j.jaci.2003.09.008 DOI: 10.1016/j.jaci.2003.09.008
Juniper, E. F., Guyatt, G. H., Cox, F. M., Ferrie, P. J., & King, D. R. (1999). Development and validation of the mini asthma quality of life questionnaire. European Respiratory Journal, 14(1), 32–38. 10.1034/j.1399-3003.1999.14a08.x DOI: 10.1034/j.1399-3003.1999.14a08.x
Juniper, E. F., Guyatt, G. H., Willan, A., & Griffith, L. E. (1994). Determining a minimal important change in a disease-specific quality of life questionnaire. Journal of Clinical Epidemiology, 47(1), 81–87. 10.1016/0895-4356(94)90036-1 DOI: 10.1016/0895-4356(94)90036-1
Schatz, M., Sorkness, C. A., Li, J. T., et al. (2006). Asthma control test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists. The Journal of Allergy and Clinical Immunology, 117(3), 549–556. 10.1016/j.jaci.2006.01.011 DOI: 10.1016/j.jaci.2006.01.011
Demarche, S. F., Schleich, F. N., Henket, M. A., Paulus, V. A., Van Hees, T. J., & Louis, R. E. (2017). Effectiveness of inhaled corticosteroids in real life on clinical outcomes, sputum cells and systemic inflammation in asthmatics: A retrospective cohort study in a secondary care centre. BMJ Open. 10.1136/bmjopen-2017-018186 DOI: 10.1136/bmjopen-2017-018186
Price, D., Musgrave, S. D., Shepstone, L., et al. (2011). Leukotriene Antagonists as first-line or add-on asthma-controller therapy. New England Journal of Medicine, 364(18), 1695–1707. 10.1056/nejmoa1010846 DOI: 10.1056/nejmoa1010846
Chen, H., Gould, M. K., Blanc, P. D., et al. (2007). Asthma control, severity, and quality of life: Quantifying the effect of uncontrolled disease. The Journal of Allergy and Clinical Immunology, 120(2), 396–402. 10.1016/j.jaci.2007.04.040 DOI: 10.1016/j.jaci.2007.04.040
Scott, S., Currie, J., Albert, P., Calverley, P., & Wilding, J. P. H. (2012). Risk of misdiagnosis, health-related quality of life, and BMI in patients who are overweight with doctor-diagnosed asthma. Chest, 141(3), 616–624. 10.1378/chest.11-0948 DOI: 10.1378/chest.11-0948
Dixon, A. E., Pratley, R. E., Forgione, P. M., et al. (2011). Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control and inflammation. The Journal of Allergy and Clinical Immunology, 128(3), 508. 10.1016/J.JACI.2011.06.009 DOI: 10.1016/J.JACI.2011.06.009
Peerboom, S., Graff, S., Seidel, L., et al. (2020). Predictors of a good response to inhaled corticosteroids in obesity-associated asthma. Biochem Pharmacol. 10.1016/j.bcp.2020.113994 DOI: 10.1016/j.bcp.2020.113994
Demarche, S. F., Schleich, F. N., Paulus, V. A., Henket, M. A., Van Hees, T. J., & Louis, R. E. (2017). Asthma control and sputum eosinophils: A longitudinal study in daily practice. The Journal of Allergy and Clinical Immunology. In Practice, 5(5), 1335-1343.e5. 10.1016/j.jaip.2017.01.026 DOI: 10.1016/j.jaip.2017.01.026
Schleich, F. N., Seidel, L., Sele, J., et al. (2010). Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma. Thorax, 65(12), 1039–1044. 10.1136/thx.2009.124925 DOI: 10.1136/thx.2009.124925
Roberts, G., Mylonopoulou, M., Hurley, C., & Lack, G. (2005). Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clinical and Experimental Allergy, 35(10), 1295–1300. 10.1111/j.1365-2222.2005.02333.x DOI: 10.1111/j.1365-2222.2005.02333.x
Pavord, I. D., Brightling, C. E., Woltmann, G., & Wardlaw, A. J. (1999). Non-eosinophilic corticosteroid unresponsive asthma. Lancet, 353(9171), 2213–2214. 10.1016/S0140-6736(99)01813-9 DOI: 10.1016/S0140-6736(99)01813-9
Green, R. H., Brightling, C. E., McKenna, S., et al. (2002). Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial. Lancet, 360(9347), 1715–1721. 10.1016/S0140-6736(02)11679-5 DOI: 10.1016/S0140-6736(02)11679-5
Price, D. B., Buhl, R., Chan, A., et al. (2018). Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: A randomised controlled trial. The Lancet Respiratory Medicine, 6(1), 29–39. 10.1016/S2213-2600(17)30424-1 DOI: 10.1016/S2213-2600(17)30424-1
Gibeon, D., Heaney, L. G., Brightling, C. E., et al. (2015). Dedicated severe asthma services improve health-care use and quality of life. Chest, 148(4), 870–876. 10.1378/chest.14-3056 DOI: 10.1378/chest.14-3056
Onyirimba, F., Apter, A., Reisine, S., et al. (2003). Direct clinician-to-patient feedback discussion of inhaled steroid use: Its effect on adherence. Annals of Allergy, Asthma & Immunology, 90(4), 411–415. 10.1016/S1081-1206(10)61825-X DOI: 10.1016/S1081-1206(10)61825-X
Park, J., Jackson, J., Skinner, E., Ranghell, K., Saiers, J., & Cherney, B. (2010). Impact of an adherence intervention program on medication adherence barriers, asthma control, and productivitydaily activities in patients with asthma. Journal of Asthma, 47(10), 1072–1077. 10.3109/02770903.2010.485660 DOI: 10.3109/02770903.2010.485660
França-Pinto, A., Mendes, F. A. R., De Carvalho-Pinto, R. M., et al. (2015). Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: A randomised controlled trial. Thorax, 70(8), 732–739. 10.1136/thoraxjnl-2014-206070 DOI: 10.1136/thoraxjnl-2014-206070
Dixon, A. E., Blake, K. V., DiMango, E. A., et al. (2021). The challenge of addressing obesity in people with poorly controlled asthma. Obesity Science & Practice, 7(6), 682–689. 10.1002/osp4.533 DOI: 10.1002/osp4.533
Pinnock, H. (2015). Supported self-management for asthma. Breathe, 11(2), 99–109. 10.1183/20734735.015614 DOI: 10.1183/20734735.015614
Pétré, B., Degrange, S., Tittaferante, S., et al. (2016). Hospital and general therapeutic patient education practices: Example of diabetes and obesity in Belgium. Sante Publique, 28(3), 287–298. 10.3917/spub.163.0287 DOI: 10.3917/spub.163.0287
Harari, S. (2018). Randomised controlled trials and real-life studies: Two answers for one question. European Respiratory Review. 10.1183/16000617.0080-2018 DOI: 10.1183/16000617.0080-2018
Vandenplas, O., Dramaix, M., Joos, G., et al. (2010). The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy European Journal Allergy Clinical Immunology, 65(10), 1290–1297. 10.1111/j.1398-9995.2010.02365.x DOI: 10.1111/j.1398-9995.2010.02365.x
Chen, W., Lynd, L. D., FitzGerald, J. M., Marra, C. A., Rousseau, R., & Sadatsafavi, M. (2015). The added effect of comorbidity on health-related quality of life in patients with asthma. Quality of Life Research, 24(10), 2507–2517. 10.1007/s11136-015-0995-6 DOI: 10.1007/s11136-015-0995-6