Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics.

[en] ("[en] PURPOSE: Asthma negatively impacts health-related quality of life (HRQL). The objective is to investigate the longitudinal relationship between HRQL in asthma and disease control, demographic and clinical objective parameters in an adult population in real-life settings. METHODS: We conducted a longitudinal study on adult asthmatics recruited from Liege University Hospital Asthma Clinic (Belgium) between 2011 and 2019. We selected those who had two visits and completed two patient-reported outcome measures (PROMs), the asthma control test (ACT) and the mini asthma quality of life questionnaire (AQLQ) (n = 290). AQLQ was the dependent variable. Demographic, functional and inflammatory characteristics, asthma control, and exacerbations were the independent variables. We applied generalized linear mixed models to identify the factors associated with change in AQLQ and its dimensions. RESULTS: Median (IQR) time interval between the two visits was 7 (5-19) months. Overall, median (IQR) global AQLQ increased from 4.1 (3-5.1) to 4.6 (3.4-5.9) (p < 0.0001). All AQLQ dimensions significantly improved, apart the environmental one. AQLQ improved in patients who had both step-up and step-down pharmacological treatment as well as in patients reporting no change between the two visits. The fitted models indicated that change in ACT was the main predictor of change in AQLQ (p < 0.0001). A rise in 3 units in ACT predicted an improvement of 0.5 AQLQ (AUC-ROC = 0.85; p < 0.0001). Change in BMI inversely impacted global AQLQ (p < 0.01) and its activity dimension (p < 0.0001). CONCLUSION: Asthma control and BMI are key predictors of asthma quality of life acting in an opposite direction. AQLQ may improve without step-up in the pharmacological treatment.","[en] ","")

Disciplines :

Public health, health care sciences & services

Author, co-author :

Louis, Gilles ; Université de Liège - ULiège > Santé publique : de la Biostatistique à la Promotion de la Santé

Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés

Schleich, FLorence ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Zahrei, Halehsadat Nekoee; Department of Public Health, Biostatistics Unit, University of Liège, Liège, Belgium

Donneau, Anne-Françoise ; Université de Liège - ULiège > Département des sciences de la santé publique

Henket, Monique ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

PAULUS, Virginie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

GUISSARD, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Guillaume, Michèle ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques

Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Language :

English

Title :

Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics.

Publication date :

03 January 2023

Journal title :

Quality of Life Research

ISSN :

0962-9343

eISSN :

1573-2649

Publisher :

Springer Science and Business Media LLC, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/content/pdf/10.1007/s11136-022-03339-0.pdf

Funders :

BELSPO - Belgian Science Policy Office
Interreg

Available on ORBi :

since 06 February 2023

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