Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer

Peiffer, Raphaël; Boumahd, Yasmine; Gullo, Charlotte; Crake, Rebekah; Letellier, Elisabeth; Bellahcene, Akeila; Peulen, Olivier

doi:10.3390/cancers15010061

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Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer

Peiffer, Raphaël; Boumahd, Yasmine; Gullo, Charlotte et al.

2022 • In Cancers, 15 (1), p. 61

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10.3390/cancers15010061

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Keywords :

pancreatic cancer; PDAC; cancer-associated fibroblast; CAF; metabolism; paracrine signaling; desmoplasia; hypoxia; acidosis

Abstract :

[en] Cancer-associated fibroblasts (CAFs) represent an important stromal cell population of pancreatic cancer in which multiple CAF subtypes have been identified. CAFs engage in a bidirectional crosstalk with cancer cells, continuously adapting their metabolism to external factors, such as chemotherapy. In this review, we summarize recently identified CAF subtypes in pancreatic cancer and discuss how CAFs shape cancer cell metabolism through several mechanisms, notably metabolite exchange, paracrine signaling, desmoplasia/hypoxia and acidosis.

Research center :

GIGA-LRM - GIGA Cancer-Metastases Research Laboratory - ULiège

Disciplines :

Oncology

Author, co-author :

Peiffer, Raphaël ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

Boumahd, Yasmine ; Université de Liège - ULiège > GIGA

Gullo, Charlotte ; Université de Liège - ULiège > GIGA

Crake, Rebekah ; Université de Liège - ULiège > GIGA > GIGA Cancer - Metastases Research Laboratory

Letellier, Elisabeth; Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg

Bellahcene, Akeila ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques

Peulen, Olivier ; Université de Liège - ULiège > GIGA > GIGA Cancer - Metastases Research Laboratory

Language :

English

Title :

Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer

Publication date :

22 December 2022

Journal title :

Cancers

eISSN :

2072-6694

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Special issue title :

Molecular Mechanisms of Cancer: Focus on Metabolism and Microenvironment

Volume :

Issue :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fondation Léon Fredericq [BE]

Available on ORBi :

since 12 January 2023

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