Article (Scientific journals)
Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer
Peiffer, Raphaël; Boumahd, Yasmine; Gullo, Charlotte et al.
2022In Cancers, 15 (1), p. 61
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Keywords :
pancreatic cancer; PDAC; cancer-associated fibroblast; CAF; metabolism; paracrine signaling; desmoplasia; hypoxia; acidosis
Abstract :
[en] Cancer-associated fibroblasts (CAFs) represent an important stromal cell population of pancreatic cancer in which multiple CAF subtypes have been identified. CAFs engage in a bidirectional crosstalk with cancer cells, continuously adapting their metabolism to external factors, such as chemotherapy. In this review, we summarize recently identified CAF subtypes in pancreatic cancer and discuss how CAFs shape cancer cell metabolism through several mechanisms, notably metabolite exchange, paracrine signaling, desmoplasia/hypoxia and acidosis.
Research center :
GIGA-LRM - GIGA Cancer-Metastases Research Laboratory - ULiège
Disciplines :
Oncology
Author, co-author :
Peiffer, Raphaël  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Boumahd, Yasmine ;  Université de Liège - ULiège > GIGA
Gullo, Charlotte  ;  Université de Liège - ULiège > GIGA
Crake, Rebekah  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Metastases Research Laboratory
Letellier, Elisabeth;  Molecular Disease Mechanisms Group, University of Luxembourg, Esch-sur-Alzette, Luxembourg
Bellahcene, Akeila ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Peulen, Olivier  ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Metastases Research Laboratory
Language :
English
Title :
Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer
Publication date :
22 December 2022
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Special issue title :
Molecular Mechanisms of Cancer: Focus on Metabolism and Microenvironment
Volume :
15
Issue :
1
Pages :
61
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fondation Léon Fredericq [BE]
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since 12 January 2023

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