Article (Scientific journals)
Daytime rest: Association with 24-h rest-activity cycles, circadian timing and cognition in older adults.
Reyt, Mathilde; Deantoni, Michele; Baillet, Marion et al.
2022In Journal of Pineal Research, e12820, p. 1-11
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Keywords :
actigraphy; ageing; circadian rhythm; cognition; melatonin; rest; Endocrinology
Abstract :
[en] Growing epidemiological evidence points toward an association between fragmented 24-h rest-activity cycles and cognition in the aged. Alterations in the circadian timing system might at least partially account for these observations. Here, we tested whether daytime rest (DTR) is associated with changes in concomitant 24-h rest probability profiles, circadian timing and neurobehavioural outcomes in healthy older adults. Sixty-three individuals (59-82 years) underwent field actigraphy monitoring, in-lab dim light melatonin onset assessment and an extensive cognitive test battery. Actimetry recordings were used to measure DTR frequency, duration and timing and to extract 24-h rest probability profiles. As expected, increasing DTR frequency was associated not only with higher rest probabilities during the day, but also with lower rest probabilities during the night, suggesting more fragmented night-time rest. Higher DTR frequency was also associated with lower episodic memory performance. Moreover, later DTR timing went along with an advanced circadian phase as well as with an altered phase angle of entrainment between the rest-activity cycle and circadian phase. Our results suggest that different DTR characteristics, as reflective indices of wake fragmentation, are not only underlined by functional consequences on cognition, but also by circadian alteration in the aged.
Disciplines :
Neurosciences & behavior
Author, co-author :
Reyt, Mathilde  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Deantoni, Michele ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Baillet, Marion ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Lesoinne, Alexia ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Laloux, Sophie ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron)
Lambot, Eric ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron)
Demeuse, Justine  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Calaprice, Chiara;  Department of Clinical Chemistry, University Hospital of Liège, University of Liège, Liège, Belgium
Le Goff, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chimie clinique
Collette, Fabienne  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Vandewalle, Gilles  ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Maquet, Pierre  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Hammad, Grégory   ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Schmidt, Christina   ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
More authors (5 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Daytime rest: Association with 24-h rest-activity cycles, circadian timing and cognition in older adults.
Publication date :
29 July 2022
Journal title :
Journal of Pineal Research
ISSN :
0742-3098
eISSN :
1600-079X
Publisher :
John Wiley and Sons Inc, England
Volume :
e12820
Pages :
1-11
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 757763 - COGNAP - To nap or not to nap? Why napping habits interfere with cognitive fitness in ageing
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ERC - European Research Council [BE]
Funding text :
This study was supported by the European Research Council (ERC, ERCStG‐COGNAP) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 757763). This study was also supported by the Fonds de la Recherche Scientifique—FNRS under Grant nr T.0220.20. C. S., F. C. and G. V. are research associates and MD is a FRIA grantee of the Fonds de la Recherche Scientifique—FNRS, Belgium.
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