Article (Scientific journals)
Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline.
Chylinski, Daphné; Van Egroo, Maxime; Narbutas, Justinas et al.
2022In eLife, 11, p. 78191
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Keywords :
Alzheimer's disease; ageing; human; memory; neuroscience; sleep; sleep slow waves; General Immunology and Microbiology; General Biochemistry, Genetics and Molecular Biology; General Medicine; General Neuroscience
Abstract :
[en] Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer's disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD processes is not fully established. Here, we investigated whether the coupling of spindles and slow waves (SW) is associated with early amyloid-β (Aβ) brain burden, a hallmark of AD neuropathology, and cognitive change over 2 years in 100 healthy individuals in late-midlife (50-70 years; 68 women). We found that, in contrast to other sleep metrics, earlier occurrence of spindles on slow-depolarisation SW is associated with higher medial prefrontal cortex Aβ burden (p=0.014, r²β*=0.06) and is predictive of greater longitudinal memory decline in a large subsample (p=0.032, r²β*=0.07, N=66). These findings unravel early links between sleep, AD-related processes, and cognition and suggest that altered coupling of sleep microstructure elements, key to its mnesic function, contributes to poorer brain and cognitive trajectories in ageing.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Chylinski, Daphné  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Van Egroo, Maxime ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Narbutas, Justinas ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Berthomier, Christian;  Physip SA, Paris, France
SALMON, Eric  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Bastin, Christine  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Phillips, Christophe  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Collette, Fabienne  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
MAQUET, Pierre  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Carrier, Julie ;  Centre for Advanced Research in Sleep Medicine, Université de Montréal, Montreal, Canada
Lina, Jean-Marc;  Centre for Advanced Research in Sleep Medicine, Université de Montréal, Montreal, Canada
Vandewalle, Gilles  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
More authors (4 more) Less
Language :
English
Title :
Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline.
Publication date :
31 May 2022
Journal title :
eLife
eISSN :
2050-084X
Publisher :
eLife Sciences Publications, Ltd, England
Volume :
11
Pages :
e78191
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FWB - Fédération Wallonie-Bruxelles [BE]
ERDF - European Regional Development Fund [BE]
CIHR - Canadian Institutes of Health Research [CA]
GE - General Electric [US-MA] [US-MA]
Fondation Recherche Alzheimer [BE]
Available on ORBi :
since 30 June 2022

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