Reference : HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Michiels, C. [> > > >]
Minet, E. [> > > >]
Michel, G. [> > > >]
Mottet, Denis mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
Piret, J. P. [ > > ]
Raes, M. [> > > >]
Taylor & Francis Ltd
Yes (verified by ORBi)
[en] Animals ; Anoxia/enzymology/genetics ; DNA-Binding Proteins/metabolism ; Endothelial Growth Factors/biosynthesis/genetics ; Gene Expression Regulation ; Humans ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Lymphokines/biosynthesis/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Nuclear Proteins/metabolism ; Transcription Factor AP-1/metabolism ; Transcription Factors ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors
[en] HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la Recherche dans l'Industrie et l'Agriculture ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy

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