HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.

Animals; Anoxia/enzymology/genetics; DNA-Binding Proteins/metabolism; Endothelial Growth Factors/biosynthesis/genetics; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphokines/biosynthesis/genetics; Mitogen-Activated Protein Kinases/metabolism; Nuclear Proteins/metabolism; Transcription Factor AP-1/metabolism; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Abstract :

[en] HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology

Author, co-author :

Michiels, C.

Minet, E.

Michel, G.

Mottet, Denis ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Piret, J. P.

Raes, M.

Language :

English

Title :

HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.

Publication date :

2001

Journal title :

IUBMB Life

ISSN :

1521-6543

eISSN :

1521-6551

Publisher :

Taylor & Francis Ltd

Volume :

Issue :

1-2

Pages :

49-53

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique

Available on ORBi :

since 24 November 2009

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