Profil

Mottet Denis

GIGA Molecul. Biolog. of Diseases - Gene Expression & Cancer

Département des sciences biomédicales et précliniques

See author's contact details
Main Referenced Co-authors
Peixoto, Paul  (36)
Castronovo, Vincenzo  (33)
Piel, Géraldine  (30)
Matheus, Nicolas  (27)
Evrard, Brigitte  (26)
Main Referenced Keywords
HDAC5 (18); Cancer (17); Humans (16); siRNA (15); Hypoxia-Inducible Factor 1, alpha Subunit (12);
Main Referenced Unit & Research Centers
Centre Interfacultaire de Recherche du Médicament - CIRM (15)
Giga-Cancer - ULiège [BE] (10)
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (7)
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE] (3)
CERM - Center for Education and Research on Macromolecules - ULiège (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (37)
Oncology (29)
Pharmacy, pharmacology & toxicology (29)
Life sciences: Multidisciplinary, general & others (16)
Chemistry (4)

Publications (total 95)

The most downloaded
2004 downloads
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., Adhihetty, P. J., Adler, S. G., Agam, G., Agarwal, R., Aghi, M. K., Agnello, M., Agostinis, P., Aguilar, P. V., Aguirre-Ghiso, J., ... Choubey, V. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi:10.1080/15548627.2015.1100356 https://hdl.handle.net/2268/194756

The most cited

4277 citations (Scopus®)

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., Adhihetty, P. J., Adler, S. G., Agam, G., Agarwal, R., Aghi, M. K., Agnello, M., Agostinis, P., Aguilar, P. V., Aguirre-Ghiso, J., ... Choubey, V. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi:10.1080/15548627.2015.1100356 https://hdl.handle.net/2268/194756

Mignon, J., Leyder, T., Mottet, D., Uversky, V. N., & Michaux, C. (14 March 2024). In-depth investigation of the effect of pH on the autofluorescence properties of DPF3b and DPF3a amyloid fibrils. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 313, 124156. doi:10.1016/j.saa.2024.124156
Peer Reviewed verified by ORBi

Berger, M.* , Toussaint, F.* , Djemaa, S. B.* , Maquoi, E., Pendeville-Samain, H., Evrard, B., Jérôme, C., Chain, J. L., Lechanteur, A., Mottet, D.* , Debuigne, A.* , & Piel, G.*. (2023). Poly(N-methyl‐N‐vinylacetamide): a strong alternative to PEG for lipid‐based nanocarriers delivering siRNA. Advanced Healthcare Materials, 2302712. doi:10.1002/adhm.202302712
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Musawi, S., Donnio, L.-M., Zhao, Z., Magnani, C., Rassinoux, P., Binda, O., Huang, J., Jacquier, A., Coudert, L., Lomonte, P., Martinat, C., Schaeffer, L., Mottet, D., Côté, J., Mari, P.-O., & Giglia-Mari, G. (15 November 2023). Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments. Nature Communications, 14 (1), 7384. doi:10.1038/s41467-023-42390-4
Peer Reviewed verified by ORBi

Berger, M.* , Toussaint, F.* , Djemaa, S. B.* , Laloy, J., Pendeville-Samain, H., Evrard, B., Jérôme, C., Lechanteur, A., Mottet, D.* , Debuigne, A.* , & Piel, G.*. (02 August 2023). Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery. Journal of Controlled Release, 361, 87 - 101. doi:10.1016/j.jconrel.2023.07.031
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Debuigne, A., Piel, G., Mottet, D., Toussaint, F., Berger, M., Ben Djemaa, S., & Lechanteur, A. (2023). Polymer Derivative and their use as lipid nanoparticle modifiers”.

Leyder, T., Mignon, J., Mottet, D., & Michaux, C. (04 December 2022). Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a. International Journal of Molecular Sciences, 23 (23), 15291. doi:10.3390/ijms232315291
Peer Reviewed verified by ORBi

Mignon, J., Mottet, D., Leyder, T., Uversky, V. N., Perpète, E. A., & Michaux, C. (01 October 2022). Structural characterisation of amyloidogenic intrinsically disordered zinc finger protein isoforms DPF3b and DPF3a. International Journal of Biological Macromolecules, 218, 57 - 71. doi:10.1016/j.ijbiomac.2022.07.102
Peer Reviewed verified by ORBi

Berger, M., Toussaint, F., Ben Djemaa, S., Evrard, B., Jérôme, C., Lechanteur, A., Mottet, D., Debuigne, A., & Piel, G. (30 March 2022). Development of innovative grafted lipoplexes using PNVP-derivatives polymers as a PEG alternative to treat cancer [Paper presentation]. 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (PBP World Meeting), Rotterdam, Netherlands.

Berger, M., Toussaint, F., Ben Djemaa, S., Evrard, B., Jérôme, C., Lechanteur, A., Mottet, D., Debuigne, A., & Piel, G. (09 March 2022). Development of innovative grafted lipoplexes using PNVP-derivatives polymers as a PEG alternative to treat cancer [Paper presentation]. 2022 Meeting of the Germany and BeNeLux & France Local Chapters of the Controlled Release Society in Aachen, Aachen, Germany.

Duchemin, A., O'Grady, T., Hanache, S., Mereau, A., Thiry, M., Wacheul, L., Michaux, C., Perpète, E., Hervouet, E., Peixoto, P., Ernst, F., Audic, Y., Dequiedt, F., Lafontaine, D., & Mottet, D. (2021). DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity. Nature Communications. doi:10.1038/s41467-021-26932-2
Peer Reviewed verified by ORBi

Hanache, S., Duchemin, A., O'Grady, T., Mereau, A., Thiry, M., Wacheul, L., Michaux, C., Perpète, E., Hervouet, E., Peixoto, P., Ernst, F., Audic, Y., Dequiedt, F., Lafontaine, D., & Mottet, D. (17 October 2021). DHX15-independent roles for TFIP11 in U6 snRNA modi!cation, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity [Poster presentation]. EMBL.

Warnon, C., Bouhjar, K., Ninane, N., Verhoyen, M., Fattaccioli, A., Fransolet, M., Lambert de Rouvroit, C., Poumay, Y., Piel, G., Mottet, D., & Debacq-Chainiaux, F. (12 July 2021). HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts. Aging, 13, 17978-18005. doi:10.18632/aging.203304
Peer Reviewed verified by ORBi

Toussaint, F., Berger, M., Sanaa, B. D., Lechanteur, A., Jérôme, C., Piel, G., Mottet, D., & Debuigne, A. (27 May 2021). Polyvinylpyrrolidone compounds as PEG alternatives for lipoplex modification [Poster presentation]. Belgian Polymer Group (BPG) Annual Meeting, remote, Belgium.

Berger, M., Toussaint, F., Ben Djemaa, S., Evrard, B., Jérôme, C., Debuigne, A., Mottet, D., Lechanteur, A., & Piel, G. (May 2021). Impact of amphiphilic N-vinyl pyrrolidone-based polymers used as PEG alternative on lipoplexes physico-chemical properties, cytotoxicity and gene delivery [Poster presentation]. Center for Interdisciplinary Research on Medicines (CIRM) Scientific Day, Liège, Belgium.

Bellefroid, C., Reusch, C., Lechanteur, A., Evrard, B., Debacq-Chainiaux, Mottet, D., & Piel, G. (2021). Systematic study of liposomes composition towards efficient delivery of plasmid DNA as potential application of dermal fibroblasts targeting. International Journal of Pharmaceutics, 592, 120122. doi:10.1016/j.ijpharm.2020.120122
Peer Reviewed verified by ORBi

Mignon, J., Mottet, D., Verrillo, G., Matagne, A., Perpète, E. A., & Michaux, C. (2021). Revealing Intrinsic Disorder and Aggregation Properties of the DPF3a Zinc Finger Protein. ACS Omega, 6 (29), 18793-18801. doi:10.1021/acsomega.1c01948
Peer Reviewed verified by ORBi

Bellefroid, C., Lechanteur, A., Evrard, B., Mottet, D., Debacq-Chainiaux, F., & Piel, G. (15 December 2019). In vitro skin penetration enchancement techniques: a combined approach of ethosomes and microneedles. International Journal of Pharmaceutics, 572. doi:10.1016/j.ijpharm.2019.118793
Peer Reviewed verified by ORBi

Hanache, S., Duchemin, A., Peixoto, P., Hervouet, E., Dequiedt, F., & Mottet, D. (01 February 2019). Phospho-Dependant Regulation Of TFIP11 Splicing Factor [Poster presentation]. BACR.

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Vernos, I., Orange, F., Martin, M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (February 2019). Unveiling of a new role for DPF3 protein in cancer biology [Poster presentation]. Belgian Association for Cancer Research (BACR) meeting 2019.

Veloso, A., Martin, M., Bruyr, J., O'Grady, T., Deroanne, C., Mottet, D., Twizere, J.-C., Cherrier, T.* , & Dequiedt, F.*. (2019). Dephosphorylation of HDAC4 by PP2A-Bdelta unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Cell death & disease, 10 (7), 512. doi:10.1038/s41419-019-1743-6
Peer reviewed
* These authors have contributed equally to this work.

Lechanteur, A., Sanna, V., Duchemin, A., Evrard, B., Mottet, D., & Piel, G. (August 2018). Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape [Paper presentation]. 12th International Conference and Workshop on Biological barriers, Saarbruck, Germany.

Lechanteur, A., Sanna, V., Duchemin, A., Evrard, B., Mottet, D., & Piel, G. (2018). Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape. In Cationic liposomes carrying siRNA: impact of lipid composition on physicochemical properties, cytotoxicity and endosomal escape.
Peer reviewed

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (01 February 2018). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. Télévie's Researchers Seminar 2018.

Lechanteur, A., Sanna, V., Duchemin, A., Evrard, B., Mottet, D., & Piel, G. (2018). Cationic Liposomes Carrying siRNA: Impact of Lipid Composition on Physicochemical Properties, Cytotoxicity and Endosomal Escape. Nanomaterials, 8 (5). doi:10.3390/nano8050270
Peer Reviewed verified by ORBi

Verrillo, G., Hanache, S., Duchemin, A., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (11 May 2017). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. PhD Day.

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103
Peer Reviewed verified by ORBi

Verrillo, G., Duchemin, A., Hanache, S., Herfs, M., DELVENNE, P., Tassin, A.-M., Dequiedt, F., Twizere, J.-C., & Mottet, D. (01 February 2017). Unveiling a New Role of DPF3 Protein in Cancer Biology [Poster presentation]. Giga Day.

Frère, A., Baroni, A., Hendrick, E., Delvigne, A. S., Orange, F., Peulen, O., Dakwar, G., Diricq, J., Dubois, P., Evrard, B., Remaut, K., Braeckmans, K., De Smedt, S., Laloy, J., Dogne, J. M., Feller, G., Mespouilles, L., Mottet, D., & Piel, G. (2017). PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy. ACS Applied Materials and Interfaces, 25 (9(3)), 2181-2195. doi:10.1021/acsami.6b15064
Peer Reviewed verified by ORBi

Frère, A., Evrard, B., Mottet, D., & Piel, G. (2016). Polymeric Nanoparticles as siRNA Drug Delivery System for Cancer Therapy: The Long Road to Therapeutic Efficiency. In A. M. Holban & A. Grumezescu (Eds.), Nanoarchitectonics for Smart Delivery and Drug Targeting (pp. 503-540). Elsevier. doi:10.1016/B978-0-323-47347-7.00018-5
Peer reviewed

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., Adhihetty, P. J., Adler, S. G., Agam, G., Agarwal, R., Aghi, M. K., Agnello, M., Agostinis, P., Aguilar, P. V., Aguirre-Ghiso, J., ... Choubey, V. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12 (1), 1-222. doi:10.1080/15548627.2015.1100356
Peer Reviewed verified by ORBi

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Eppe, G., Castronovo, V., & Mottet, D. (03 December 2015). Compensatory Metabolism Promotes Cancer Cell Adaptation to HDAC5 Silencing [Poster presentation]. Séminaires des chercheurs Télévie 2016, Gembloux, Belgium.

Frère, A., Baroni, A., Peulen, O., Orange, F., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (December 2015). Pegylated Polyplexes Based On HDAC5 siRNA And Aliphatic Polycarbonate Polymers For An Anticancer Therapy [Poster presentation]. European Nanomedicine Meeting, Grenoble, France.

Frère, A., Baroni, A., Peulen, O., Orange, F., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (23 November 2015). Pegylated Polyplexes Based On HDAC5 siRNA And Aliphatic Polycarbonate Polymers For An Anticancer Therapy [Poster presentation]. Biopharmacy Day, Leuven, Belgium.

Frère, A., Tempelaar, S., Peulen, O., Evrard, B., Dubois, P., Mottet, D., & Piel, G. (September 2015). Polyplexes Based on Polycarbonate Polymers and HDAC5 siRNA Efficiently Decrease the Proliferation of Cancer Cells [Poster presentation]. UniGR biomedecine workshop, Arlon, Belgium.

Frère, A., Tempelaar, S., Peulen, O., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (02 June 2015). Polyplex Based on Polycarbonate Polymers for an Efficient Delivery of HDAC5 and HDAC7 siRNA [Poster presentation]. Biomedica 2015, Genk, Belgium.

Frère, A., Evrard, B., Mottet, D., & Piel, G. (28 May 2015). Polyplex Based on Polycarbonate Polymers for an Efficient Delivery of HDAC5 and HDAC7 siRNA [Paper presentation]. 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (11 February 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Seminaires des chercheurs Télévie 2015, Bruxelles, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (31 January 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. ABEC TUmor Metabolism and Mitochondria, Bruxelles, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (27 January 2015). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Giga Cancer Day 2015 Current Advances in Medical Genetics and Genomics, Liège, Belgium.

Frère, A., Kawalec, M., Tempelaar, S., Peixoto, P., Hendrick, E., Peulen, O., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (2015). Impact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability. Biomacromolecules. doi:10.1021/bm501676p
Peer Reviewed verified by ORBi

Frère, A., Evrard, B., Mespouille, L., Mottet, D., & Piel, G. (12 December 2014). Polyplex based on polycarbonate polymers for an efficient delivery of HDAC5 and HDAC7 siRNA [Paper presentation]. Biopharmacy Day, Vlaardingen, Netherlands.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (30 September 2014). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Paper presentation]. Annual Mini symposium 2014, Liège, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (25 September 2014). HDAC5 Depletion in Cancer Cells Induces an Oxidative Stress and Leads to a Metabolic Reprogramming toward Glucose and Glutamine Metabolism [Poster presentation]. Metabolism and Cancer Nice, Nice, France.

Polese, C., & Mottet, D. (01 September 2014). Inhiber HDAC5 : un outil pour couper court à l’immortalité des cellules cancéreuses. MS. Medecine Sciences, 30 (numero 8-9), 730-732. doi:10.1051/medsci/20143008005
Peer Reviewed verified by ORBi

Frère, A., Tempelaar, S., Peixoto, P., Peulen, O., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (28 August 2014). Polyplex based on polycarbonate polymesr for an efficient delivery of an anti-angiogenic siRNA [Paper presentation]. Translational Nanomedicine, Angers, France.

Frère, A., Kawalec, M., Tempelaar, S., Peixoto, P., Peulen, O., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (26 May 2014). Impact of the Structure of Biocompatible Aliphatic Polycarbonate on siRNA Transfection Ability [Poster presentation]. Advanced Functional Polymers for Medicine AFPM) 2014, Liège, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (19 May 2014). Glucose-dependent metabolic reprogramming in HDAC5-depleted cancer cells [Poster presentation]. Giga Cancer Day 2014 THE LYMPHATIC SYSTEM : THE BED AND BENCH POINT OF VIEWS, Liège, Belgium.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (25 April 2014). Glucose-dependent metabolic reprogramming in HDAC5-depleted cancer cells [Poster presentation]. Reactive Oxygen Species in Cell Metabolism 11th Meeting of the FRS-FNRS contact group on oxidative stress and anti-oxidants 210th Meeting of the Belgian Society of Biochemistry and Molecular Biology, Belgium.

Frère, A., Peixoto, P., Kawalec, M., Evrard, B., Mespouille, L., Mottet, D., & Piel, G. (April 2014). Polyplexes Targeting Angiogenesis in Cancer [Poster presentation]. 9th World Meeting on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology, Lisbon, Portugal.

Hendrick, E., Peixoto, P., Polese, C., Matheus, N., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (01 February 2014). Complex I Mitochondrial Dysfunction in HDAC5-depleted Cancer Cells Induces Glucose-dependent Metabolic Reprogramming [Poster presentation]. Association Belge pour l'étude du cancer A.B.E.C 2014, Anvers, Belgium.

Hendrick, E., Peixoto, P., Matheus, N., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Sonveaux, P., Castronovo, V., & Mottet, D. (27 January 2014). Complex I Mitochondrial Dysfunction in HDAC5-depleted Cancer Cells Induces Glucose-dependent Metabolic Reprogramming [Poster presentation]. Giga Day 2014, Liège, Belgium.

Matheus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., LAMBERT, V., Noël, A., Frederich, M., Mottet, D., & De Tullio, P. (January 2014). An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics. Phytochemical Analysis, 25, 342-349. doi:10.1002/pca.2498
Peer Reviewed verified by ORBi

Frère, A., Kawalec, M., Tempelaar, S., Peixoto, P., Peulen, O., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (2014). Polyplex Based On Polycarbonate Polymers For An Efficient Delivery Of An Anti-Angiogenic siRNA [Poster presentation]. 3rd NanoFar Autumn School, Brussels, Belgium.

Frère, A., Krier, F., Evrard, B., Mottet, D., & Piel, G. (2014). Polyplex Based On Polycarbonate Polymers For An Efficient Delivery Of An Anti-Angiogenic siRNA [Poster presentation]. 2014 AAPS Annual Meeting and Exposition, San Diego, United States.

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., Elmoualij, B., De Tullio, P., Castronovo, V., & Mottet, D. (05 December 2013). HDAC5 depletion Decreases NDUFB5 Subunit of Mitochondrial Complex- I leading to Glucose-dependent Metabolic Reprogrammation [Poster presentation]. Séminaire des chercheurs Télévie 2014, Bruxelles, Belgium.

Frère, A., Kawalec, M., Peixoto, P., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (December 2013). The intracellular fate of polycarbonate Polyplexes modulates the efficacy of siRNA [Poster presentation]. 28th GTRV annual meeting, Orleans, France.

Frère, A., Peixoto, P., Mottet, D., & Piel, G. (17 October 2013). Polyplexes based on polycarbonate polymers and siRNA against HDAC7 for a targeted anti-angiogenic therapy [Paper presentation]. 17th forum of Pharmaceutical Sciences, Spa, Belgium.

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (13 September 2013). Complexe I mitochondrial dysfunction in HDAC5 depleted cancer cells induces glucose-dependent metabolic reprogrammation [Poster presentation]. Annual Mini symposium 2013, Bruxelles, Belgium.

Peulen, O.* , Gonzalez, A.* , Peixoto, P., Turtoi, A., Mottet, D., Delvenne, P., & Castronovo, V. (11 September 2013). The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2. PLoS ONE, 8 (9), 75102. doi:10.1371/journal.pone.0075102
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Novo, C. L., Polese, C., Matheus, N., Decottignies, A., Londono-Vallejo, A., Castronovo, V., & Mottet, D. (September 2013). A new role for histone deacetylase 5 in the maintenance of long telomeres. FASEB Journal, 27. doi:10.1096/fj.12-224204
Peer Reviewed verified by ORBi

Gonzalez, A., Peixoto, P., Turtoi, A., Mottet, D., Delvenne, P., Castronovo, V., & Peulen, O. (11 July 2013). Concomitant inhibition of class I HDAC and COX-2 exerts a antitumor effect in a human pancreatic cancer model [Poster presentation]. WIN2013 Symposium: "Personalized Cancer Therapy: from innovation to implemantation".

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Blomme, A., Mouithys-Mickalad, A., Serteyn, D., De Tullio, P., Elmoualij, B., Castronovo, V., & Mottet, D. (17 May 2013). Mitochondrial dysfunction in HDAC5-depleted cancer cells induces glucose-dependent metabolic adaptation [Poster presentation]. GIGA-Cancer Day 2013, Liège, Belgium.

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Mouithys-Mickalad, A., Serteyn, D., Michiels, C., Castronovo, V., & Mottet, D. (02 February 2013). JNK/ROS signaling pathway is responsible for induction of autophagy in HDAC5 depleted cancer cells [Poster presentation]. Association Belge pour l'étude du cancer A.B.E.C 2013, Gand, Belgium.

Hendrick, E., Matheus, N., Peixoto, P., Polese, C., Mouithys-Mickalad, A., Serteyn, D., Castronovo, V., & Mottet, D. (29 January 2013). JNK/ROS Signaling Pathway Is Responsible for Induction of Autophagy in HDAC5 depleted Cancer Cells [Paper presentation]. Journée Scientifique des doctorants en sciences Biomédicales et Pharmaceutiques, Mons, Belgium.

Martin, M., Geudens, I., Bruyr, J., Potente, M., Bleuart, A., Lebrun, M., Simonis, N., Deroanne, C., Twizere, J.-C., Soubeyran, P., Peixoto, P., Mottet, D., Janssens, V., Hofmann, W.-K., Claes, F., Carmeliet, P., Kettmann, R., Gerhardt, H., & Dequiedt, F. (2013). PP2A regulatory subunit Balpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO Journal. doi:10.1038/emboj.2013.187
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Hendrick, E., Peixoto, P., Matheus, N., Polese, C., Castronovo, V., & Mottet, D. (10 December 2012). Role of HDAC5 depletion induced autophagy on cancer cell death [Poster presentation]. Séminaires des chercheurs Télévie 2013, Liège, Belgium.

Frère, A., Kawalec, M., Collard, L., Matheus, N., Peixoto, P., Evrard, B., Dubois, P., Mespouille, L., Mottet, D., & Piel, G. (22 October 2012). Characterization and transfection experiments of polyplexes targeting HDAC7 [Poster presentation]. NanoFar Autumn School, Angers, France.

Castronovo, V., Matheus, N., Dumont, B., Peixoto, P., Hennequière, V., Deroanne, C., Colige, A., De Pauw, E., Bellahcene, A., Mottet, D., & Turtoi, A. (21 April 2012). The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells [Paper presentation]. Experimental Biology 2012, SAN DIEGO, United States.

Peixoto, P., Matheus, N., Polese, C., gonzalez, A., Castronovo, V., & Mottet, D. (04 February 2012). HDAC5 is required for maintenance of pericentric heterochromatin and controls cell cycle progression of human cancer cells [Poster presentation]. Belgian Association for Cancer Research Annual Meeting 2012.

Peixoto, P., Castronovo, V., Matheus, N., Polese, C., Peulen, O., Gonzalez, A., Boxus, M., Verdin, E., Thiry, M., Dequiedt, F., & Mottet, D. (2012). HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell Death and Differentiation. doi:10.1038/cdd.2012.3
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Kasler, H. G., Lim, H. W., Mottet, D., Collins, A. M., Lee, I. S., & Verdin, E. (2012). Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance. EMBO Journal. doi:10.1038/emboj.2012.295
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Peixoto, P., Castronovo, V., Matheus, N., Polese, C., Peulen, O., Gonzalez, A., Boxus, M., Verdin, E., Thiry, M., Dequiedt, F., & Mottet, D. (2012). Implication of HDAC-5 in heterochromatin replication [Poster presentation]. GIGA-DAY.

Peixoto, P., Castronovo, V., Matheus, N., Polese, C., Peulen, O., Gonzalez, A., Boxus, M., Verdin, E., Thiry, M., Dequiedt, F., & Mottet, D. (2012). HDAC5 depletion modulates heterochromatin plasticity and triggers programmed cell death of human cancer cells [Poster presentation]. GIGA-DAY.

Turtoi, A., Mottet, D., Matheus, N., Dumont, B., Peixoto, P., Hennequière, V., Deroanne, C., Colige, A., De Pauw, E., Bellahcene, A., & Castronovo, V. (2012). The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. doi:10.1007/s10456-012-9279-8
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Kasler, H. G., Young, B. D., Mottet, D., Lim, H. W., Collins, A. M., Olson, E. N., & Verdin, E. (11 March 2011). Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes. Journal of Immunology, 186 (8), 4782-93. doi:10.4049/jimmunol.1001179
Peer Reviewed verified by ORBi

Peixoto, P., Pirotte, S., Matheus, N., Castronovo, V., & Mottet, D. (05 February 2011). Histone deacetylase 5 is a regulator of S phase progression [Poster presentation]. Belgian Association for Cancer Research Annual Meeting, Liège, Belgium.

Pirotte, S., Lamour, V., Lambert, V., Alvarez Gonzalez, M.-L., Ormenese, S., Noël, A., Mottet, D., Castronovo, V., & Bellahcene, A. (2011). Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood, 117 (8), 2515-26. doi:10.1182/blood-2010-08-298810
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Mottet, D., & Castronovo, V. (December 2010). Histone deacetylases: anti-angiogenic targets in cancer therapy. Current Cancer Drug Targets, 10 (8), 898-913. doi:10.2174/156800910793358014
Peer Reviewed verified by ORBi

Mottet, D., Pirotte, S., Lamour, V., Hagedorn, M., Javerzat, S., Bikfalvi, A., Bellahcene, A., Castronovo, V., & Verdin, E. (2009). HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene, 28 (2), 243-56. doi:10.1038/onc.2008.371
Peer Reviewed verified by ORBi

Mottet, D., & Castronovo, V. (2008). Les histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses. MS. Medecine Sciences, 24 (8-9), 742-6. doi:10.1051/medsci/20082489742
Peer Reviewed verified by ORBi

Mottet, D., Bellahcene, A., Pirotte, S., Waltregny, D., Deroanne, C., Lamour, V., Lidereau, R., & Castronovo, V. (07 December 2007). Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circulation Research, 101 (12), 1237-1246. doi:10.1161/CIRCRESAHA.107.149377
Peer Reviewed verified by ORBi

Mottet, D., & Castronovo, V. (2007). Histone Deacetylases: Target Enzymes for Cancer Therapy. Clinical and Experimental Metastasis. doi:10.1007/s10585-007-9131-5
Peer Reviewed verified by ORBi

Mottet, D., Ruys, S. P. D., Demazy, C., Raes, M., & Michiels, C. (2005). Role for casein kinase 2 in the regulation of HIF-1 activity. International Journal of Cancer, 117 (5), 764-74. doi:10.1002/ijc.21268
Peer Reviewed verified by ORBi

Mottet, D., Dumont, V., Deccache, Y., Demazy, C., Ninane, N., Raes, M., & Michiels, C. (2003). Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. Journal of Biological Chemistry, 278 (33), 31277-85. doi:10.1074/jbc.M300763200
Peer Reviewed verified by ORBi

Mottet, D., Michel, G., Renard, P., Ninane, N., Raes, M., & Michiels, C. (2003). Role of ERK and calcium in the hypoxia-induced activation of HIF-1. Journal of Cellular Physiology, 194 (1), 30-44. doi:10.1002/jcp.10176
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Piret, J.-P., Mottet, D., Raes, M., & Michiels, C. (2002). CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Annals of the New York Academy of Sciences, 973, 443-7. doi:10.1111/j.1749-6632.2002.tb04680.x
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Mottet, D., Michel, G., Renard, P., Ninane, N., Raes, M., & Michiels, C. (2002). ERK and calcium in activation of HIF-1. Annals of the New York Academy of Sciences, 973, 448-53. doi:10.1111/j.1749-6632.2002.tb04681.x
Peer Reviewed verified by ORBi

Michiels, C., Minet, E., Mottet, D., & Raes, M. (2002). Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes. Free Radical Biology and Medicine, 33 (9), 1231-42. doi:10.1016/S0891-5849(02)01045-6
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Michel, G., Minet, E., Mottet, D., Remacle, J., & Michiels, C. (2002). Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain. Biochimica et Biophysica Acta, 1578 (1-3), 73-83. doi:10.1016/S0167-4781(02)00484-0
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Piret, J.-P., Mottet, D., Raes, M., & Michiels, C. (2002). Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochemical Pharmacology, 64 (5-6), 889-92. doi:10.1016/S0006-2952(02)01155-3
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Minet, E., Michel, G., Mottet, D., Piret, J. P., Barbieux, A., Raes, M., & Michiels, C. (2001). c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells. Experimental Cell Research, 265 (1), 114-24. doi:10.1006/excr.2001.5180
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Minet, E., Michel, G., Mottet, D., Raes, M., & Michiels, C. (2001). Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation. Free Radical Biology and Medicine, 31 (7), 847-55. doi:10.1016/S0891-5849(01)00657-8
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Michiels, C., Minet, E., Michel, G., Mottet, D., Piret, J. P., & Raes, M. (2001). HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases. IUBMB Life, 52 (1-2), 49-53. doi:10.1080/15216540252774766
Peer Reviewed verified by ORBi

Minet, E., Arnould, T., Michel, G., Roland, I., Mottet, D., Raes, M., Remacle, J., & Michiels, C. (2000). ERK activation upon hypoxia: involvement in HIF-1 activation. FEBS Letters, 468 (1), 53-8. doi:10.1016/S0014-5793(00)01181-9
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Minet, E., Mottet, D., Michel, G., Roland, I., Raes, M., Remacle, J., & Michiels, C. (1999). Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Letters, 460 (2), 251-6. doi:10.1016/S0014-5793(99)01359-9
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