Article (Scientific journals)
Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers
GREGOIRE, Céline; HUYNEN, Pascale; Gofflot, Stéphanie et al.
2022In Scientific Reports, 12, p. 9790
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Keywords :
SARS-CoV-2; COVID-19; Seroprevalence; Risk factors; Healthcare worker
Abstract :
[en] While patient groups at risk for severe COVID-19 infections are now well identified, the risk factors associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission and immunization are still poorly understood. In a cohort of staff members of a Belgian tertiary academic hospital tested for SARS-CoV-2 antibodies during the early phase of the pandemic and followed-up after 6 weeks, 3 months and 10 months, we collected personal, occupational and medical data, as well as symptoms based on which we constructed a COVID-19 score. Seroprevalence was higher among participants in contact with patients or with COVID-19 confirmed subjects or, to a lesser extent, among those handling respiratory specimens, as well as among participants reporting an immunodeficiency or a previous or active hematological malignancy, and correlated with several symptoms. In multivariate analysis, variables associated with seropositivity were: contact with COVID-19 patients, immunodeficiency, previous or active hematological malignancy, anosmia, cough, nasal symptoms, myalgia, and fever. At 10 months, participants in contact with patients and those with higher initial COVID-19 scores were more likely to have sustained antibodies, whereas those with solid tumors or taking chronic medications were at higher risk to become seronegative.
Disciplines :
Immunology & infectious disease
Public health, health care sciences & services
Author, co-author :
GREGOIRE, Céline   ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
HUYNEN, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique
Gofflot, Stéphanie ;  Université de Liège - ULiège > GIGA
Seidel, Laurence  ;  Université de Liège - ULiège > Département des sciences de la santé publique
Maes, Nathalie ;  Université de Liège - ULiège > Département des sciences de la santé publique
VRANKEN, Laura ;  Centre Hospitalier Universitaire de Liège - CHU > > Secteur commun NDB
DELCOUR, Sandra ;  Centre Hospitalier Universitaire de Liège - CHU > > Secteur commun prélèvements - dispa - labo central Corelab
MOUTSCHEN, Michel  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique
KOLH, Philippe  ;  Université de Liège - ULiège > GIGA ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et pathologiques ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
MELIN, Pierrette  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
 These authors have contributed equally to this work.
Language :
English
Title :
Predictive factors for the presence and long-term persistence of SARS-CoV-2 antibodies in healthcare and university workers
Publication date :
13 June 2022
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Springer Science and Business Media LLC
Volume :
12
Pages :
9790
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Région wallonne [BE]
Leon Fredericq Foundation [BE]
Available on ORBi :
since 13 June 2022

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