Ahmad, R., Lahuna, O., Sidibe, A., Daulat, A., Zhang, Q., Luka, M., Jockers, R., GPR50-Ctail cleavage and nuclear translocation: A new signal transduction mode for G protein-coupled receptors. Cellular and Molecular Life Sciences: CMLS 77:24 (2020), 5189–5205.
Alavi, M.S., Shamsizadeh, A., Azhdari-Zarmehri, H., Roohbakhsh, A., Orphan G protein-coupled receptors: The role in CNS disorders. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 98 (2018), 222–232.
Alexander, S.P., Christopoulos, A., Davenport, A.P., Kelly, E., Mathie, A., Peters, J.A., Ye, R.D., THE concise guide to pharmacology 2021/22: G protein-coupled receptors. British Journal of Pharmacology 178:Suppl 1(S1) (2021), S27–S156.
Alexander, S.P.H., Mathie, A., Peters, J.A., Histamine. British Journal of Pharmacology, 2006, S48.
Amisten, S., Salehi, A., Rorsman, P., Jones, P.M., Persaud, S.J., An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacology & Therapeutics 139:3 (2013), 359–391.
Anney, R.J.L., Lasky-Su, J., O'Dúshláine, C., Kenny, E., Neale, B.M., Mulligan, A., Gill, M., Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics 147B:8 (2008), 1369–1378.
Bäck, M., Powell, W.S., Dahlén, S.-E., Drazen, J.M., Evans, J.F., Serhan, C.N., Rovati, G.E., Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR review 7. British Journal of Pharmacology 171:15 (2014), 3551–3574.
Ballesteros, J.A., Jensen, A.D., Liapakis, G., Rasmussen, S.G.F., Shi, L., Gether, U., Javitch, J.A., Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6*. The Journal of Biological Chemistry 276:31 (2001), 29171–29177.
Ballesteros, J.A., Weinstein, H., Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Sealfon, S.C., (eds.) Methods in neurosciences, Vol. 25, 1995, Academic Press, 366–428.
Berndt, S., Liebscher, I., New structural perspectives in G protein-coupled receptor-mediated Src family kinase activation. International Journal of Molecular Sciences, 22(12), 2021.
Bjarnadóttir, T.K., Gloriam, D.E., Hellstrand, S.H., Kristiansson, H., Fredriksson, R., Schiöth, H.B., Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 88:3 (2006), 263–273.
Breton, T.S., Sampson, W.G.B., Clifford, B., Phaneuf, A.M., Smidt, I., True, T., DiMaggio, M.A., Characterization of the G protein-coupled receptor family SREB across fish evolution. Scientific Reports, 11(1), 2021, 12066.
Carpenter, B., Tate, C.G., Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces. Current Opinion in Structural Biology 45 (2017), 124–132.
Chen, J.-Y., Early crest animals and the insight they provide into the evolutionary origin of craniates. Genesis (New York, N.Y.: 2000) 46:11 (2008), 623–639.
Chen, Q., Kogan, J.H., Gross, A.K., Zhou, Y., Walton, N.M., Shin, R., Matsumoto, M., SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory. The European Journal of Neuroscience 36:5 (2012), 2597–2608.
Chopra, D.G., Yiv, N., Hennings, T.G., Zhang, Y., Ku, G.M., Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Scientific Reports, 10(1), 2020, 5629.
Civelli, O., Reinscheid, R.K., Zhang, Y., Wang, Z., Fredriksson, R., Schiöth, H.B., G protein-coupled receptor deorphanizations. Annual Review of Pharmacology and Toxicology 53 (2013), 127–146.
Davenport, A.P., Alexander, S.P.H., Sharman, J.L., Pawson, A.J., Benson, H.E., Monaghan, A.E., Harmar, A.J., International union of basic and clinical pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacological Reviews 65:3 (2013), 967–986.
Delsuc, F., Brinkmann, H., Chourrout, D., Philippe, H., Tunicates and not cephalochordates are the closest living relatives of vertebrates. Nature 439:7079 (2006), 965–968.
Deupi, X., Standfuss, J., Structural insights into agonist-induced activation of G-protein-coupled receptors. Current Opinion in Structural Biology 21:4 (2011), 541–551.
Devic, E., Xiang, Y., Gould, D., Kobilka, B., Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Molecular Pharmacology 60:3 (2001), 577–583.
Dolanc, D., Zorec, T.M., Smole, Z., Maver, A., Horvat, A., Pillaiyar, T., Zorec, R., The activation of GPR27 increases cytosolic L-lactate in 3T3 embryonic cells and astrocytes. Cells, 11(6), 2022.
Dores, R.M., Hagfish, genome duplications, and RFamide neuropeptide evolution [review of hagfish, genome duplications, and RFamide neuropeptide evolution]. Endocrinology 152:11 (2011), 4010–4013 The Endocrine Society.
Du, Y., Duc, N.M., Rasmussen, S.G.F., Hilger, D., Kubiak, X., Wang, L., Chung, K.Y., Assembly of a GPCR-G protein complex. Cell 177:5 (2019), 1232–1242.e11.
Dupuis, N., Laschet, C., Franssen, D., Szpakowska, M., Gilissen, J., Geubelle, P., Hanson, J., Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-Arrestin 2 recruitment. Molecular Pharmacology 91:6 (2017), 595–608.
Eddy, M.T., Lee, M.-Y., Gao, Z.-G., White, K.L., Didenko, T., Horst, R., Wüthrich, K., Allosteric coupling of drug binding and intracellular signaling in the A2A adenosine receptor. Cell 172:1–2 (2018), 68–80.e12.
Edwards, A.M., Isserlin, R., Bader, G.D., Frye, S.V., Willson, T.M., Yu, F.H., Too many roads not taken. Nature 470:7333 (2011), 163–165.
Elion, E.A., Pheromone response, mating and cell biology. Current Opinion in Microbiology 3:6 (2000), 573–581.
Engelstoft, M.S., Park, W.-M., Sakata, I., Kristensen, L.V., Husted, A.S., Osborne-Lawrence, S., Schwartz, T.W., Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Molecular Metabolism 2:4 (2013), 376–392.
Filipek, S., Molecular switches in GPCRs. Current Opinion in Structural Biology 55 (2019), 114–120.
Flanagan, C.A., A GPCR that is not “DRY.”. Molecular Pharmacology 68:1 (2005), 1–3.
Foster, S.R., Hauser, A.S., Vedel, L., Strachan, R.T., Huang, X.-P., Gavin, A.C., Gloriam, D.E., Discovery of human signaling systems: Pairing peptides to G protein-coupled receptors. Cell 179:4 (2019), 895–908.e21.
Fredriksson, R., Lagerström, M.C., Lundin, L.-G., Schiöth, H.B., The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Molecular Pharmacology 63:6 (2003), 1256–1272.
Fujita-Jimbo, E., Tanabe, Y., Yu, Z., Kojima, K., Mori, M., Li, H., Momoi, T., The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: A molecular analysis. Molecular Autism, 6, 2015, 17.
Grundmann, M., Tikhonova, I.G., Hudson, B.D., Smith, N.J., Mohr, K., Ulven, T., Kostenis, E., A molecular mechanism for sequential activation of a G protein-coupled receptor. Cell Chemical Biology 23:3 (2016), 392–403.
Hanson, M.A., Roth, C.B., Jo, E., Griffith, M.T., Scott, F.L., Reinhart, G., Stevens, R.C., Crystal structure of a Lipid G protein–coupled receptor. Science 335:6070 (2012), 851–855.
Hauser, A.S., Attwood, M.M., Rask-Andersen, M., Schiöth, H.B., Gloriam, D.E., Trends in GPCR drug discovery: New agents, targets and indications. Nature Reviews. Drug Discovery 16:12 (2017), 829–842.
Hauser, A.S., Kooistra, A.J., Munk, C., Heydenreich, F.M., Veprintsev, D.B., Bouvier, M., Gloriam, D.E., GPCR activation mechanisms across classes and macro/microscales. Nature Structural & Molecular Biology 28:11 (2021), 879–888.
Hellebrand, S., Chica Schaller, H., Wittenberger, T., The brain-speci¢c G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q311. Biochimica et Biophysica Acta 1493 (2000), 269–272.
Hill, C.A., Fox, A.N., Pitts, R.J., Kent, L.B., Tan, P.L., Chrystal, M.A., Zwiebel, L.J., G protein-coupled receptors in Anopheles gambiae. Science 298:5591 (2002), 176–178.
Hoffmann, C., Moro, S., Nicholas, R.A., Harden, T.K., Jacobson, K.A., The role of amino acids in extracellular loops of the human P2Y1 receptor in surface expression and activation processes. The Journal of Biological Chemistry 274:21 (1999), 14639–14647.
Holst, B., Nygaard, R., Valentin-Hansen, L., Bach, A., Engelstoft, M.S., Petersen, P.S., Schwartz, T.W., A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors. The Journal of Biological Chemistry 285:6 (2010), 3973–3985.
Hossain, M.S., Mineno, K., Katafuchi, T., Neuronal orphan G-protein coupled receptor proteins mediate Plasmalogens-induced activation of ERK and Akt signaling. PLoS One, 11(3), 2016, e0150846.
Huang, S., Chen, Z., Yan, X., Yu, T., Huang, G., Yan, Q., Xu, A., Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes. Nature Communications, 5, 2014, 5896.
Huang, W., Manglik, A., Venkatakrishnan, A.J., Laeremans, T., Feinberg, E.N., Sanborn, A.L., Kobilka, B.K., Structural insights into μ-opioid receptor activation. Nature 524:7565 (2015), 315–321.
Isberg, V., Mordalski, S., Munk, C., Rataj, K., Harpsøe, K., Hauser, A.S., Gloriam, D.E., GPCRdb: An information system for G protein-coupled receptors. Nucleic Acids Research 44:D1 (2016), D356–D364.
Isensee, J., Wenzel, C., Buschow, R., Weissmann, R., Kuss, A.W., Hucho, T., Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS One, 9(12), 2014, e115731.
Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G.W., Basu, S., Cherezov, V., Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proceedings of the National Academy of Sciences of the United States of America 114:31 (2017), 8223–8228.
Ito, J., Ito, M., Nambu, H., Fujikawa, T., Tanaka, K., Iwaasa, H., Tokita, S., Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice. Cell and Tissue Research 338:2 (2009), 257–269.
Jaakola, V.-P., Griffith, M.T., Hanson, M.A., Cherezov, V., Chien, E.Y.T., Lane, J.R., Stevens, R.C., The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322:5905 (2008), 1211–1217.
Jin, C., Kang, H., Ryu, J.R., Kim, S., Zhang, Y., Lee, Y., Han, K., Integrative brain transcriptome analysis reveals region-specific and broad molecular changes in Shank3-overexpressing mice. Frontiers in Molecular Neuroscience, 11, 2018, 250.
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Hassabis, D., Highly accurate protein structure prediction with AlphaFold. Nature 596:7873 (2021), 583–589.
Kakarala, K.K., Jamil, K., Sequence-structure based phylogeny of GPCR class A rhodopsin receptors. Molecular Phylogenetics and Evolution 74 (2014), 66–96.
Katritch, V., Fenalti, G., Abola, E.E., Roth, B.L., Cherezov, V., Stevens, R.C., Allosteric sodium in class A GPCR signaling. Trends in Biochemical Sciences 39:5 (2014), 233–244.
Kempermann, G., Song, H., Gage, F.H., Neurogenesis in the adult Hippocampus. Cold Spring Harbor Perspectives in Biology, 7(9), 2015, a018812.
Kooistra, A.J., Mordalski, S., Pándy-Szekeres, G., Esguerra, M., Mamyrbekov, A., Munk, C., Gloriam, D.E., GPCRdb in 2021: Integrating GPCR sequence, structure and function. Nucleic Acids Research 49:D1 (2021), D335–D343.
Kroeze, W.K., Sassano, M.F., Huang, X.-P., Lansu, K., McCorvy, J.D., Giguère, P.M., Roth, B.L., PRESTO-tango as an open-source resource for interrogation of the druggable human GPCRome. Nature Structural & Molecular Biology 22:5 (2015), 362–369.
Ku, G.M., Pappalardo, Z., Luo, C.C., German, M.S., McManus, M.T., An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genetics, 8(1), 2012, e1002449.
Kundu, K., Mann, M., Costa, F., Backofen, R., MoDPepInt: An interactive web server for prediction of modular domain-peptide interactions. Bioinformatics 30:18 (2014), 2668–2669.
Kuwamura, T., Sunobe, T., Sakai, Y., Kadota, T., Sawada, K., Hermaphroditism in fishes: An annotated list of species, phylogeny, and mating system. Ichthyological Research 67:3 (2020), 341–360.
Lander, E.S., Linton, L.M., Birren, B., Nusbaum, C., Zody, M.C., Baldwin, J., International Human Genome Sequencing Consortium, Initial sequencing and analysis of the human genome. Nature 409:6822 (2001), 860–921.
Lando, M., Fjeldbo, C.S., Wilting, S.M., Snoek, C., Aarnes, E.-K., Forsberg, M.F., Lyng, H., Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer. Epigenetics: Official Journal of the DNA Methylation Society 10:10 (2015), 970–980.
Larco, D.O., Semsarzadeh, N.N., Cho-Clark, M., Mani, S.K., Wu, T.J., The novel actions of the metabolite GnRH-(1-5) are mediated by a G protein-coupled receptor. Frontiers in Endocrinology, 4, 2013, 83.
Larco, D.O., Semsarzadeh, N.N., Cho-Clark, M., Mani, S.K., Wu, T.J., β-Arrestin 2 is a mediator of GnRH-(1-5) signaling in immortalized GnRH neurons. Endocrinology 154:12 (2013), 4726–4736.
Laschet, C., Dupuis, N., Hanson, J., The G protein-coupled receptors deorphanization landscape. Biochemical Pharmacology 153 (2018), 62–74.
Lattin, J.E., Schroder, K., Su, A.I., Walker, J.R., Zhang, J., Wiltshire, T., Sweet, M.J., Expression analysis of G protein-coupled receptors in mouse macrophages. Immunome Research, 4, 2008, 5.
Lin, X., Li, M., Wang, N., Wu, Y., Luo, Z., Guo, S., Han, G.-W., Li, S., Yue, Y., Wei, X., Xie, X., Chen, Y., Zhao, S., Wu, J., Lei, M., Xu, F., Structural basis of ligand recognition and self-activation of orphan GPR52. Nature 579:7797 (2020), 152–157.
Liu, W., Chun, E., Thompson, A.A., Chubukov, P., Xu, F., Katritch, V., Stevens, R.C., Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337:6091 (2012), 232–236.
Livernois, A.M., Graves, J.A.M., Waters, P.D., The origin and evolution of vertebrate sex chromosomes and dosage compensation. Heredity 108:1 (2012), 50–58.
Livingston, W.S., Gill, J.M., Cota, M.R., Olivera, A., O'Keefe, J.L., Martin, C., Latour, L.L., Differential gene expression associated with meningeal injury in acute mild traumatic brain injury. Journal of Neurotrauma 34:4 (2017), 853–860.
Lu, S., Jang, W., Inoue, A., Lambert, N.A., Constitutive G protein coupling profiles of understudied orphan GPCRs. PLoS One, 16(4), 2021, e0247743.
Lu, Z.L., Curtis, C.A., Jones, P.G., Pavia, J., Hulme, E.C., The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: Mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling. Molecular Pharmacology 51:2 (1997), 234–241.
Magalhaes, A.C., Dunn, H., Ferguson, S.S., Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins. British Journal of Pharmacology 165:6 (2012), 1717–1736.
Magnani, F., Pappas, C.G., Crook, T., Magafa, V., Cordopatis, P., Ishiguro, S., Tzakos, A.G., Electronic sculpting of ligand-GPCR subtype selectivity: The case of angiotensin II. ACS Chemical Biology 9:7 (2014), 1420–1425.
Marion, S., Oakley, R.H., Kim, K.-M., Caron, M.G., Barak, L.S., A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. The Journal of Biological Chemistry 281:5 (2006), 2932–2938.
Martin, A.L., Steurer, M.A., Aronstam, R.S., Constitutive activity among orphan class-A G protein coupled receptors. PLoS One, 10(9), 2015, e0138463.
Matsumoto, M., Beltaifa, S., Weickert, C.S., Herman, M.M., Hyde, T.M., Saunders, R.C., Kleinman, J.E., A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Brain Research. Molecular Brain Research 138:1 (2005), 58–69.
Matsumoto, M., Saito, T., Takasaki, J., Kamohara, M., Sugimoto, T., Kobayashi, M., Tadokoro, M., Matsumoto, S., Ohishi, T., Furuichi, K., An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochemical and Biophysical Research Communications 272:2 (2000), 576–582.
Matsumoto, M., Straub, R.E., Marenco, S., Nicodemus, K.K., Matsumoto, S.-I., Fujikawa, A., Weinberger, D.R., The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 105:16 (2008), 6133–6138.
Mirzadegan, T., Benkö, G., Filipek, S., Palczewski, K., Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin. Biochemistry 42:10 (2003), 2759–2767.
Moreira, D., Homology. Amils, R., Gargaud, M., Cernicharo Quintanilla, J., Cleaves, H.J., Irvine, W.M., Pinti, D., Viso, M., (eds.) Encyclopedia of astrobiology, 2014, Springer, Berlin Heidelberg, 1–2.
Moreira, D., Orthologous gene. Amils, R., Gargaud, M., Cernicharo Quintanilla, J., Cleaves, H.J., Irvine, W.M., Pinti, D., Viso, M., (eds.) Encyclopedia of astrobiology, 2014, Springer, Berlin Heidelberg, 1.
Moreira, D., López-García, P., Paralogous gene. Amils, R., Gargaud, M., Cernicharo Quintanilla, J., Cleaves, H.J., Irvine, W.M., Pinti, D., Viso, M., (eds.) Encyclopedia of astrobiology, 2014, Springer, Berlin Heidelberg, 1.
Nath, A.K., Ma, J., Chen, Z.-Z., Li, Z., Vitery, M.D.C., Kelley, M.L., Yeh, J.-R.J., Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 34:1 (2020), 1546–1557.
Nicoli, A., Dunkel, A., Giorgino, T., de Graaf, C., Di Pizio, A., Classification model for the second extracellular loop of class A GPCRs. Journal of Chemical Information and Modeling 62:3 (2022), 511–522.
Nygaard, R., Frimurer, T.M., Holst, B., Rosenkilde, M.M., Schwartz, T.W., Ligand binding and micro-switches in 7TM receptor structures. Trends in Pharmacological Sciences 30:5 (2009), 249–259.
O'Dowd, B.F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K.R., Heng, H.H., George, S.R., Discovery of three novel G-protein-coupled receptor genes. Genomics 47:2 (1998), 310–313.
Olstad, O.K., Gautvik, V.T., Reppe, S., Rian, E., Jemtland, R., Ohlsson, C., Gautvik, K.M., Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning. Anticancer Research 23:3B (2003), 2201–2216.
Paavola, K.J., Hall, R.A., Adhesion G protein-coupled receptors: Signaling, pharmacology, and mechanisms of activation. Molecular Pharmacology 82:5 (2012), 777–783.
Pal, S., Chattopadhyay, A., Extramembranous regions in G protein-coupled receptors: Cinderella in receptor biology?. The Journal of Membrane Biology 252:4–5 (2019), 483–497.
Pariani, M.J., Spencer, A., Graham, J.M. Jr., Rimoin, D.L., A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. European Journal of Medical Genetics 52:2–3 (2009), 123–127.
Patel, C., Cooper-Charles, L., McMullan, D.J., Walker, J.M., Davison, V., Morton, J., Translocation breakpoint at 7q31 associated with tics: Further evidence for IMMP2L as a candidate gene for Tourette syndrome. European Journal of Human Genetics: EJHG 19:6 (2011), 634–639.
Pert, C.B., Pasternak, G., Snyder, S.H., Opiate agonists and antagonists discriminated by receptor binding in brain. Science 182:4119 (1973), 1359–1361.
Pertwee, R.G., Howlett, A.C., Abood, M.E., Alexander, S.P., Di Marzo, V., Elphick, M.R., Ross, R.A., International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacological Review 62:4 (2010), 588–631.
Petek, E., Windpassinger, C., Simma, B., Mueller, T., Wagner, K., Kroisel, P.M., Molecular characterisation of a 15 Mb constitutional de novo interstitial deletion of chromosome 3p in a boy with developmental delay and congenital anomalies. Journal of Human Genetics 48:6 (2003), 283–287.
Pillaiyar, T., Rosato, F., Wozniak, M., Blavier, J., Charles, M., Laschet, C., Hanson, J., Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27. European Journal of Medicinal Chemistry, 225, 2021, 113777.
Radulescu, E., Sambataro, F., Mattay, V.S., Callicott, J.H., Straub, R.E., Matsumoto, M., Marenco, S., Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology Vol. 38:2 (2013), 341–349.
Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., Kobilka, B.K., Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature 469:7329 (2011), 175–180.
Regard, J.B., Sato, I.T., Coughlin, S.R., Anatomical profiling of G protein-coupled receptor expression. Cell 135:3 (2008), 561–571.
Ribrioux, S., Brüngger, A., Baumgarten, B., Seuwen, K., John, M.R., Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts. BMC Genomics, 9, 2008, 122.
Rosenbaum, D.M., Rasmussen, S.G.F., Kobilka, B.K., The structure and function of G-protein-coupled receptors. Nature 459:7245 (2009), 356–363.
Rosenkilde, M.M., Kledal, T.N., Schwartz, T.W., High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (asp-Arg-Tyr) in transmembrane helix 3. Molecular Pharmacology 68:1 (2005), 11–19.
Roth, B.L., Kroeze, W.K., Integrated approaches for genome-wide interrogation of the Druggable non-olfactory G protein-coupled receptor superfamily. The Journal of Biological Chemistry 290:32 (2015), 19471–19477.
Rovati, G.E., Capra, V., Neubig, R.R., The highly conserved DRY motif of class A G protein-coupled receptors: Beyond the ground state. Molecular Pharmacology 71:4 (2007), 959–964.
Sakai, A., Yasui, T., Watanave, M., Tatsumi, R., Yamamoto, Y., Takano, W., Takeda, S., Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain. Genes to Cells: Devoted to Molecular & Cellular Mechanisms 27:5 (2022), 345–355.
Schöneberg, T., Hofreiter, M., Schulz, A., Römpler, H., Learning from the past: Evolution of GPCR functions. Trends in Pharmacological Sciences 28:3 (2007), 117–121.
Smith, N.J., Ward, R.J., Stoddart, L.A., Hudson, B.D., Kostenis, E., Ulven, T, Milligan, G., Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Molecular Pharmacology 80:1 (2011), 163–173.
Smith, S.O., Deconstructing the transmembrane core of class A G protein–coupled receptors. Trends in Biochemical Sciences, 2021, 10.1016/j.tibs.2021.08.006.
Soppa, J., Two hypotheses–one answer. Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. FEBS Letters 342:1 (1994), 7–11.
Sriram, K., Insel, P.A., G protein-coupled receptors as targets for approved drugs: How many targets and how many drugs?. Molecular Pharmacology 93:4 (2018), 251–258.
Stäubert, C., Tarnow, P., Brumm, H., Pitra, C., Gudermann, T., Grüters, A., Schöneberg, T., Biebermann, H., Römpler, H., Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 148:10 (2007), 4642–4648.
Stein, L.M., Tullock, C.W., Mathews, S.K., Garcia-Galiano, D., Elias, C.F., Samson, W.K., Yosten, G.L.C., Hypothalamic action of phoenixin to control reproductive hormone secretion in females: Importance of the orphan G protein-coupled receptor Gpr173. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 311:3 (2016), R489–R496.
Storjohann, L., Holst, B., Schwartz, T.W., A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39. Biochemistry 47:35 (2008), 9198–9207.
Strasser, A., Wittmann, H.-J., Schneider, E.H., Seifert, R., Modulation of GPCRs by monovalent cations and anions. Naunyn-Schmiedeberg's Archives of Pharmacology 388:3 (2015), 363–380.
Strotmann, R., Schröck, K., Böselt, I., Stäubert, C., Russ, A., Schöneberg, T., Evolution of GPCR: Change and continuity. Molecular and Cellular Endocrinology 331:2 (2011), 170–178.
Szpakowska, M., Meyrath, M., Reynders, N., Counson, M., Hanson, J., Steyaert, J., Chevigné, A., Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists. Biochemical Pharmacology 153 (2018), 299–309.
Szpakowska, M., Perez Bercoff, D., Chevigné, A., Closing the ring: A fourth extracellular loop in chemokine receptors. Science Signaling, 7(341), 2014, e21.
Treen, A.K., Luo, V., Belsham, D.D., Phoenixin activates immortalized GnRH and Kisspeptin neurons through the novel receptor GPR173. Molecular Endocrinology 30:8 (2016), 872–888.
Trzaskowski, B., Latek, D., Yuan, S., Ghoshdastider, U., Debinski, A., Filipek, S., Action of molecular switches in GPCRs–theoretical and experimental studies. Current Medicinal Chemistry 19:8 (2012), 1090–1109.
Tuteja, N., Signaling through G protein coupled receptors. Plant Signaling & Behavior 4:10 (2009), 942–947.
Varadi, M., Anyango, S., Deshpande, M., Nair, S., Natassia, C., Yordanova, G., Velankar, S., AlphaFold protein structure database: Massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Research 50:D1 (2022), D439–D444.
Venkatakrishnan, A.J., Deupi, X., Lebon, G., Heydenreich, F.M., Flock, T., Miljus, T., Babu, M.M., Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region. Nature 536:7617 (2016), 484–487.
Verweij, E.W.E., Al Araaj, B., Prabhata, W.R., Prihandoko, R., Nijmeijer, S., Tobin, A.B., Vischer, H.F., Differential role of Serines and Threonines in intracellular loop 3 and C-terminal tail of the histamine H4 receptor in β-Arrestin and G protein-coupled receptor kinase interaction, internalization, and signaling. ACS Pharmacology & Translational Science 3:2 (2020), 321–333.
Wang, H., Du, D., Huang, J., Wang, S., He, X., Yuan, S., Xiao, J., GPR27 regulates hepatocellular carcinoma progression via MAPK/ERK pathway. Cancer Management and Research 14 (2022), 1165–1177.
Wang, J., Hua, T., Liu, Z.-J., Structural features of activated GPCR signaling complexes. Current Opinion in Structural Biology 63 (2020), 82–89.
Wang, S., Che, T., Levit, A., Shoichet, B.K., Wacker, D., Roth, B.L., Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature 555:7695 (2018), 269–273.
Wang, S., Wacker, D., Levit, A., Che, T., Betz, R.M., McCorvy, J.D., Roth, B.L., D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science., 2017, 10.1126/science.aan5468.
van de Weg, C.A.M., van den Ham, H.-J., Bijl, M.A., Anfasa, F., Zaaraoui-Boutahar, F., Dewi, B.E., Andeweg, A.C., Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue. PLoS Neglected Tropical Diseases, 9(3), 2015, e0003522.
Wheatley, M., Wootten, D., Conner, M.T., Simms, J., Kendrick, R., Logan, R.T., Barwell, J., Lifting the lid on GPCRs: The role of extracellular loops. British Journal of Pharmacology 165:6 (2012), 1688–1703.
Whittaker, R.J., Cephalochordates, the lancelets. Gilbert, S.F., Raunio, A.M., (eds.) Embryology: Constructing the organism, 1997, Oxford University Press Incorporated.
Williams, C.R., Gallagher, E.P., Effects of cadmium on olfactory mediated behaviors and molecular biomarkers in coho salmon (Oncorhynchus kisutch). Aquatic Toxicology 140-141 (2013), 295–302.
Wittenberger, T., Schaller, H.C., Hellebrand, S., An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. Journal of Molecular Biology 307:3 (2001), 799–813.
Woolley, M.J., Conner, A.C., Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family. Molecular and Cellular Endocrinology 449 (2017), 3–11.
Yanai, T., Kurosawa, A., Nikaido, Y., Nakajima, N., Saito, T., Osada, H., Konno, A., Hirai, H., Takeda, S., Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. Genes to Cells: Devoted to Molecular & Cellular Mechanisms 21:7 (2016), 717–727.
Yañez-Guerra, L.A., Thiel, D., Jékely, G., Pre-metazoan origin of neuropeptide signalling. Molecular Biology and Evolution, 39(4), 2022.
Ye, R.D., Boulay, F., Wang, J.M., Dahlgren, C., Gerard, C., Parmentier, M., Murphy, P.M., International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacological Reviews 61:2 (2009), 119–161.
Zhou, Q., Yang, D., Wu, M., Guo, Y., Guo, W., Zhong, L., Zhao, S., Common activation mechanism of class A GPCRs. eLife, 8, 2019.
Zindel, D., Butcher, A.J., Al-Sabah, S., Lanzerstorfer, P., Weghuber, J., Tobin, A.B., Krasel, C., Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization. Molecular Pharmacology 87:2 (2015), 349–362.
Zou, R., Wang, X., Li, S., Chan, H.C.S., Vogel, H., Yuan, S., The role of metal ions in G protein-coupled receptor signalling and drug discovery. Wiley Interdisciplinary Reviews. Computational Molecular Science, 2021, 10.1002/wcms.1565.
Żuk, J., Bartuzi, D., Matosiuk, D., Kaczor, A.A., Preferential coupling of dopamine D2S and D2L receptor isoforms with Gi1 and Gi2 proteins—In silico study. International Journal of Molecular Sciences, 21(2), 2020, 436.
