Osteosarcopenia: where osteoporosis and sarcopenia collide.

bone; falls; fracture; muscle; osteoporosis; osteosarcopenia; sarcopenia; strength; Bone Density/physiology; Global Health; Humans; Osteoporosis/complications; Osteoporosis/epidemiology; Osteoporosis/metabolism; Prevalence; Sarcopenia/complications; Sarcopenia/epidemiology; Sarcopenia/metabolism; Aging; Bone Density; Rheumatology; Pharmacology (medical)

Abstract :

[en] The coexistence of osteoporosis and sarcopenia has been recently considered in some groups as a syndrome termed 'osteosarcopenia'. Osteoporosis describes low bone mass and deterioration of the micro-architecture of the bone, whereas sarcopenia is the loss of muscle mass, strength and function. With an ageing population the prevalence of both conditions is likely to increase substantially over the coming decades and is associated with significant personal and societal burden. The sequelae for an individual suffering from both conditions together include a greater risk of falls, fractures, institutionalization and mortality. The aetiology of 'osteosarcopenia' is multifactorial with several factors linking muscle and bone function, including genetics, age, inflammation and obesity. Several biochemical pathways have been identified that are facilitating the development of several promising therapeutic agents, which target both muscle and bone. In the current review we outline the epidemiology, pathogenesis and clinical consequences of 'osteosarcopenia' and explore current and potential future management strategies.

Disciplines :

Public health, health care sciences & services

Author, co-author :

Clynes, Michael A ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK

Gregson, Celia L ; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK

BRUYERE, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Cooper, Cyrus ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK ; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, UK ; NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK

Dennison, Elaine M; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK

Language :

English

Title :

Osteosarcopenia: where osteoporosis and sarcopenia collide.

Publication date :

2021

Journal title :

Rheumatology

ISSN :

1462-0324

eISSN :

1462-0332

Publisher :

Oxford University Press, England

Volume :

Issue :

Pages :

529-537

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://academic.oup.com/rheumatology/article-pdf/60/2/529/36168018/keaa755.pdf

Available on ORBi :

since 19 May 2022

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