uPARAP/Endo180: a multifaceted protein of mesenchymal cells.

Cancer; Collagen; Endocytic receptor; MRC2; Tissue remodeling; uPARAP/Endo180; Cell Biology; Cellular and Molecular Neuroscience; Pharmacology; Molecular Biology; Molecular Medicine

Abstract :

[en] The urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) is already known to be a key collagen receptor involved in collagen internalization and degradation in mesenchymal cells and some macrophages. It is one of the four members of the mannose receptor family along with a macrophage mannose receptor (MMR), a phospholipase lipase receptor (PLA2R), and a dendritic receptor (DEC-205). As a clathrin-dependent endocytic receptor for collagen or large collagen fragments as well as through its association with urokinase (uPA) and its receptor (uPAR), uPARAP/Endo180 takes part in extracellular matrix (ECM) remodeling, cell chemotaxis and migration under physiological (tissue homeostasis and repair) and pathological (fibrosis, cancer) conditions. Recent advances that have shown an expanded contribution of this multifunctional protein across a broader range of biological processes, including vascular biology and innate immunity, are summarized in this paper. It has previously been demonstrated that uPARAP/Endo180 assists in lymphangiogenesis through its capacity to regulate the heterodimerization of vascular endothelial growth factor receptors (VEGFR-2 and VEGFR-3). Moreover, recent findings have demonstrated that it is also involved in the clearance of collectins and the regulation of the immune system, something which is currently being studied as a biomarker and a therapeutic target in a number of cancers.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Gucciardo, Fabrice ; Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology

Pirson, Sébastien ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire

Baudin, Louis ; Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology

Lebeau, Alizée ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire

Noël, Agnès ; Université de Liège - ULiège > GIGA > GIGA Cancer

Language :

English

Title :

uPARAP/Endo180: a multifaceted protein of mesenchymal cells.

Publication date :

22 April 2022

Journal title :

Cellular and Molecular Life Sciences

ISSN :

1420-682X

eISSN :

1420-9071

Publisher :

Springer Science and Business Media LLC, Switzerland

Volume :

Issue :

Pages :

255

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/content/pdf/10.1007/s00018-022-04249-7.pdf

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fondation contre le Cancer [BE]
ULiège FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
Fonds Léon Fredericq [BE]
FRFS-WELBIO
FWB - Fédération Wallonie-Bruxelles [BE]

Available on ORBi :

since 10 May 2022

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