Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.

1-Phosphatidylinositol 3-Kinase/metabolism; Angiogenesis Inhibitors/genetics/metabolism; Animals; Cell Hypoxia/physiology; DNA-Binding Proteins/genetics/metabolism/pharmacology; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinases/metabolism; Nuclear Proteins/genetics/metabolism/pharmacology; Phosphorylation; Signal Transduction/physiology; Transcription Factors/metabolism/pharmacology; Transcriptional Activation/drug effects/genetics/physiology; Transduction, Genetic

Abstract :

[en] Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed.

Disciplines :

Oncology
Biochemistry, biophysics & molecular biology

Author, co-author :

Minet, E.

Michel, G.

Mottet, Denis ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases

Raes, M.

Michiels, C.

Language :

English

Title :

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.

Publication date :

2001

Journal title :

Free Radical Biology and Medicine

ISSN :

0891-5849

eISSN :

1873-4596

Publisher :

Elsevier Science, Tarrytown, United States - New York

Volume :

Issue :

Pages :

847-55

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique

Available on ORBi :

since 24 November 2009

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154

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