Reference : Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and acti...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Oncology
Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation.
Minet, E. [> > > >]
Michel, G. [> > > >]
Mottet, Denis mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases >]
Raes, M. [> > > >]
Michiels, C. [> > > >]
Free Radical Biology & Medicine
Elsevier Science
Yes (verified by ORBi)
[en] 1-Phosphatidylinositol 3-Kinase/metabolism ; Angiogenesis Inhibitors/genetics/metabolism ; Animals ; Cell Hypoxia/physiology ; DNA-Binding Proteins/genetics/metabolism/pharmacology ; Humans ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit ; Mitogen-Activated Protein Kinases/metabolism ; Nuclear Proteins/genetics/metabolism/pharmacology ; Phosphorylation ; Signal Transduction/physiology ; Transcription Factors/metabolism/pharmacology ; Transcriptional Activation/drug effects/genetics/physiology ; Transduction, Genetic
[en] Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la Recherche dans l'Industrie et l'Agriculture, Belgique ; Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy

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