Article (Scientific journals)
A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals.
Olivet, Julien; Maseko, Sibusiso Bonginkhost; Volkov, Alexander N et al.
2022In Molecular Therapy
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Keywords :
Molecular Medicine; Molecular Biology; Genetics; Pharmacology; Drug Discovery
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Olivet, Julien ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Maseko, Sibusiso Bonginkhost ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies ; Université de Liège - ULiège > GIGA > GIGA Molecular Biology of Diseases - Gene Expression & Cancer
Volkov, Alexander N;  VIB-VUB Center for Structural Biology, Flemish Institute of Biotechnology (VIB), Brussels, Belgium, Jean Jeener NMR Centre, Free University of Brussels (VUB), Brussels, Belgium
Salehi-Ashtiani, Kourosh;  Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, UAE
Das, Kalyan;  Structural Biology Unit, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research and Department of Microbiology, Immunology and Transplantation, Catholic University of Leuven (KU Leuven), Leuven, Belgium
Calderwood, Michael A;  Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI), Boston, MA, USA, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA, Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA
Twizere, Jean-Claude   ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Gorgulla, Christoph ;  Department of Cancer Biology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA, Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA, Department of Physics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA, USA. Electronic address: cgorgulla@g.harvard.edu
 These authors have contributed equally to this work.
Language :
English
Title :
A systematic approach to identify host targets and rapidly deliver broad-spectrum antivirals.
Publication date :
28 February 2022
Journal title :
Molecular Therapy
ISSN :
1525-0016
eISSN :
1525-0024
Publisher :
Cell Press, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Funding text :
J.O. thanks Wallonie-Bruxelles International (WBI-World Excellence Fellowship), the Belgian F.R.S.-FNRS-T?l?vie (FC27371, Cr?dit no. 7454518F), and the Rega Institute for Medical Research, KU Leuven for the financial support. This work was in part supported by NIAID R21 AI153738 awarded to M.A.C. and by the NYU Abu Dhabi Faculty Research Fund AD060 awarded to K.S.-A. J.-C.T. is a Ma?tre de Recherche of the Belgian F.R.S.-FNRS. C.G. thanks ChemAxon for a free academic license. This work was in part supported by NIH grants CA200913, AI037581, and GM129026 awarded to Gerhard Wagner, as well as by the ARO grant W911NF1910302 to Arthur Jaffe. J.O. J.-C.T. and C.G. wrote the manuscript with critical insight from S.B.M. A.N.V. K.S.-A. K.D. and M.A.C. All authors discussed the proposed methodology and experimental approaches. C.G. is the cofounder of two companies, Virtual Discovery, Inc. and Quantum Therapeutics, Inc. which are engaged in drug discovery activities, in part using VirtualFlow.J.O. thanks Wallonie-Bruxelles International (WBI-World Excellence Fellowship), the Belgian F.R.S.-FNRS-Télévie (FC27371, Crédit no. 7454518F ), and the Rega Institute for Medical Research, KU Leuven for the financial support. This work was in part supported by NIAID R21 AI153738 awarded to M.A.C. and by the NYU Abu Dhabi Faculty Research Fund AD060 awarded to K.S.-A. J.-C.T. is a Maître de Recherche of the Belgian F.R.S.-FNRS. C.G. thanks ChemAxon for a free academic license. This work was in part supported by NIH grants CA200913 , AI037581 , and GM129026 awarded to Gerhard Wagner, as well as by the ARO grant W911NF1910302 to Arthur Jaffe.
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