Article (Scientific journals)
Contribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases
Matagne, André; Frère, Jean-Marie
1995In Biochimica et Biophysica Acta, 1246 (2), p. 109-27
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Abstract :
[en] Class A beta-lactamases represent a family of well studied enzymes. They are responsible for many antibiotic resistance phenomena and thus for numerous failures in clinical chemotherapy. Despite the facts that five structures are known at high resolution and that detailed analyses of enzymes modified by site-directed mutagenesis have been performed, their exact catalytic mechanism remains controversial. This review attempts to summarize and to discuss the many available data.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Matagne, André  ;  Université de Liège - ULiège > Département des sciences de la vie > Enzymologie, Centre d'Ingénierie des protéines
Frère, Jean-Marie ;  Université de Liège - ULiège > Département des sciences de la vie > Enzymologie, Centre d'Ingénierie des protéines
Language :
English
Title :
Contribution of Mutant Analysis to the Understanding of Enzyme Catalysis: The Case of Class a Beta-Lactamases
Publication date :
19 January 1995
Journal title :
Biochimica et Biophysica Acta
ISSN :
0006-3002
eISSN :
1878-2434
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
1246
Issue :
2
Pages :
109-27
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 November 2009

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