Association between human gut microbiome and N-glycan composition of total plasma proteome

Petrov, Viacheslav; Sharapov, Sodbo; Shagam, Lev; Nostaeva, Arina; Pezer, Marija; Li, Dalin; Hanić, Maja; McGovern, Dermot; LOUIS, Edouard; Rahmouni, Souad; Lauc, Gordan; Georges, Michel; Aulchenko, Yurii S.

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Association between human gut microbiome and N-glycan composition of total plasma proteome

Petrov, Viacheslav; Sharapov, Sodbo; Shagam, Lev et al.

2022 • In Frontiers in Microbiology, 13:811922

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Abstract :

[en] Being one of the most dynamic entities in the human body, glycosylation of proteins fine-tunes the activity of organismal machinery, including the immune system, and mediates interaction with the human microbial consortium, typically represented by the gut microbiome. Using data from 194 healthy people, we conducted an associational study to uncover potential relations between gut microbiome and blood plasma N-glycome, including N-glycome of immunoglobulin G. While lacking strong linkages on the multivariate level, we were able to identify associations between alpha and beta microbiome diversity and blood plasma N-glycome profile. Moreover, for two bacterial genera, Bilophila and Clostridium innocuum group, significant associations with specific glycans were also shown. Our results suggest a non-trivial, possibly weak link between total plasma N-glycome and gut microbiome, predominantly involving glycans related to the immune system proteins, including immunoglobulin G. Lager studies of glycans linked to microbiome-related proteins in well-selected patient groups are required to conclusively establish specific associations.

Disciplines :

Genetics & genetic processes

Author, co-author :

Petrov, Viacheslav ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics

Sharapov, Sodbo

Shagam, Lev ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics ; Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) > GIGA-R : Génomique animale

Nostaeva, Arina

Pezer, Marija

Li, Dalin

Hanić, Maja

McGovern, Dermot

LOUIS, Edouard ; Université de Liège - ULiège > GIGA > GIGA I3 - Translational gastroenterology ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie

Rahmouni, Souad ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Université de Liège - ULiège > GIGA > GIGA Medical Genomics - Unit of Animal Genomics

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Language :

English

Title :

Association between human gut microbiome and N-glycan composition of total plasma proteome

Publication date :

29 April 2022

Journal title :

Frontiers in Microbiology

eISSN :

1664-302X

Publisher :

Frontiers, Lausanne, Switzerland

Volume :

13:811922

Peer reviewed :

Peer Reviewed verified by ORBi

Data Set :

10.3389/fmicb.2022.811922

Available on ORBi :

since 24 March 2022

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