Article (Scientific journals)
In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies
Bekisz, Sophie; Baudin, Louis; Buntinx, Florence et al.
2022In Cancers, 14 (6), p. 1525
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Keywords :
Cancer Research; Oncology; Lymphatic endothelial cells; Metastatic dissemination; In vitro models; Lymphangiogenesis; In vivo models; In silico methods; Computational models
Abstract :
[en] Lymphangiogenesis (LA) is the formation of new lymphatic vessels by lymphatic endothelial cells (LECs) sprouting from pre-existing lymphatic vessels. It is increasingly recognized as being involved in many diseases, such as in cancer and secondary lymphedema, which most often results from cancer treatments. For some cancers, excessive LA is associated with cancer progression and metastatic dissemination to the lymph nodes (LNs) through lymphatic vessels. The study of LA through in vitro, in vivo, and, more recently, in silico models is of paramount importance in providing novel insights and identifying the key molecular actors in the biological dysregulation of this process under pathological conditions. In this review, the different biological (in vitro and in vivo) models of LA, especially in a cancer context, are explained and discussed, highlighting their principal modeled features as well as their advantages and drawbacks. Imaging techniques of the lymphatics, complementary or even essential to in vivo models, are also clarified and allow the establishment of the link with computational approaches. In silico models are introduced, theoretically described, and illustrated with examples specific to the lymphatic system and the LA. Together, these models constitute a toolbox allowing the LA research to be brought to the next level.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Life sciences: Multidisciplinary, general & others
Author, co-author :
Bekisz, Sophie  ;  Université de Liège - ULiège > GIGA
Baudin, Louis ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology
Buntinx, Florence  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Noël, Agnès ;  Université de Liège - ULiège > GIGA > GIGA Cancer
Geris, Liesbet  ;  Université de Liège - ULiège > GIGA > GIGA In silico medecine - Biomechanics Research Unit
Language :
Title :
In Vitro, In Vivo, and In Silico Models of Lymphangiogenesis in Solid Malignancies
Publication date :
16 March 2022
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Volume :
Issue :
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Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ULiège. ARC - Université de Liège. Actions de Recherche Concertées [BE]
ERC - European Research Council [BE]
F.R.S.-FNRS - Fund for Scientific Research [BE]
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