animal; chemical contaminant; dioxin; farm; food safety; foodstuffs of animal origin; public health; residue; risk assessment
Abstract :
[en] Food products should not contain unsafe levels of chemical contaminants. However, it is not possible to monitor each and every one of the many thousands of chemicals that are used in our advanced societies. Chemical contaminants in foodstuffs of animal origin may be classified into three categories: natural contaminants (e.g. mycotoxins), environmental contaminants linked to industrialisation and/or urbanisation (e.g. dioxins and dioxin-like compounds) and authorised chemical products (e.g. residues of veterinary medical products). Chemical hazards may contaminate foodstuffs of animal origin all the way from farm to fork. Contamination may occur in any of the different production systems, and it is difficult to make comparisons between production systems (e.g. extensive versus intensive farming systems) with regard to food safety. Even when we take into account the latest analytical methods, which can detect ever-smaller quantities of residues, the relative importance of chemical contaminants seems to have declined during recent decades due to improvements in information and prevention. Nonetheless, individual incidents can never be ruled out and may have serious economic, health or social repercussions. Particular attention must be paid to chemical hazards, in order to reduce as much as possible the risks to livestock and to the consumer. Continued monitoring and periodic reassessment of risks posed by these contaminants (at the national level) are needed to detect or anticipate new problems, so that appropriate actions can be taken in the interest of public health. More attention should be paid to the production of detailed information, especially with regard to background data (e.g. the objectives of the monitoring, sampling methods, chemicals to be analysed, analytical methods, detection limits, raw data and specified units), in order to obtain a better basis for risk assessment. Such risk assessment provides control authorities with an effective tool for the exchange of information and measures to be taken to ensure food safety.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Saegerman, Claude ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér.
Pussemier, Luc
Huyghebaert, André
Scippo, Marie-Louise ; Université de Liège - ULiège > Département de sciences des denrées alimentaires > Analyse des denrées alimentaires
Berkvens, Dirk
Language :
English
Title :
On-farm contamination of animals with chemical contaminants
Publication date :
2006
Journal title :
Revue Scientifique et Technique. Office International des Epizooties
ISSN :
0253-1933
eISSN :
1608-0637
Publisher :
Office International des Epizooties, Paris, France
Acar J. (2006). - Antimicrobial resistance at farm level. In Animal production food safety challenges in global markets. Rev. sci. tech. Off. int. Epiz., 25 (2), 775-792.
Adams M. & Matarjemi Y. (1999). - Basic food safety for health workers. Document WHO/SDE/FOS/99.1. World Health Organization, Geneva.
Agence Fédérale belge pour la Sécurité de la Chaîne Alimentaire (2005). - Business plan pour l'Agence Alimentaire (P. Vanthemsche, ed.). Agence Fédérale pour la Sécurité de la Chaîne Alimentaire, Brussels.
Anadon A. (1985). - Standard residue regulations for chloramphenicol in Spain. Ann. Rech. vet., 16, 149-153.
Arctic Monitoring and Assessment Programme (AMAP) (2004). - Persistent toxic substances. Food security and indigenous peoples of the Russian North. Final report, Oslo, AMAP Report 2004:2. AMAP, Oslo. Available at: http://www.amap.no/ (accessed on 15 August 2005).
Attaran R.R. & Probst F. (2002). - Histamine fish poisoning: a common but frequently misdiagnosed condition. Emerg. Med. J., 19, 474-475.
Baranova M., Mala P., Pleva J. & Jackova A. (1994). - Cumulation NOx in foodstuffs and raw materials of animal origin. Arch. vet. pol., 34 (1-2), 63-68.
Barcos L. O. (2004). - Animal identification and traceability. In 72nd General Session of the International Committee, World Organisation for Animal Health (OIE), 23-28 May, Paris. OIE, Paris.
Barton H. (2005). - Predicted intake of trace elements and minerals via household drinking water by 6-year-old children from Krakow, Poland. Part 2: Cadmium, 1997-2001. Food Addit. Contam., 22 (9), 816-828.
Bender C.L., Alarcón-Chaidez F. & Gross D.C. (1999). - Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiol. molec. Biol. Rev., 63 (2), 266-292.
Bennett R.W. (2005). - Staphylococcal enterotoxin and its rapid identification in foods by enzyme-linked immunosorbent assay-based methodology. J. Food Protec., 68 (6), 1264-1270.
Beran G.W. & Baum D.H. (1997). - Food safety begins at the farm. Iowa State University (ISU), Swine research report on health, document ASL-R1512. ISU, Ames.
Bernard A., Hermans C., Broeckaert F., De Poorter G., De Cock A. & Houins G. (1999). - Food contamination by PCBs and dioxins. Nature, 401, 231-232.
Bernard A., Broeckaert F., De Poorter G., De Cock A., Hermans C., Saegerman C. & Houins G. (2002). - The Belgian PCB/Dioxin incident: analysis of the food chain contamination and health risk evaluation. Environ. Res., 88, 1-18.
Beulens A., Broens D., Folstar P. & Hofstede G. (2005). - Food safety and transparency in food chains and networks. Relationships and challenges. Food Control, 16, 481-486.
Bhat R.V. & Vasanthi S. (1999). - Contamination de l'alimentation humaine et animale par les mycotoxines. In Troisième conférence internationale mixte FAO/OMS/PNUE sur les mycotoxines, 3-6 March, Tunis. Food and Agriculture Organization, Rome, 22.
Black W.D. (1994). - Pesticide residues in foods of animal origin. In Animal drugs and human health (L.M. Crawford & D.A. Franco, eds). Technomic, Lancaster, Pennsylvania and Basel, 63-80.
Blanc M. (2001). - Nouvelles exigences en matière de sécurité sanitaire dans le commerce international des produits agricoles et agroalimentaires : incidence pour les pays d'Afrique exportateurs de produits oléagineux. Ol. Corps gras Lipides, 8, 246-250.
Boyes W.K., Tandon P., Barone S. & Padilla S. (1994). - Effects of organophosphates on the visual system of rats. J. appl. Toxicol., 13, 135-143.
Bradberry S.M., Cage S.A., Proudfoot A.T. & Vale J.A. (2005). - Poisoning due to pyrethroids. Toxicol. Rev., 24 (2), 93-106.
Canadian Food Inspection Agency (2005). - The national chemical residue monitoring program. Available at: http://www.inspection.gc.ca/english/fssa/ microchem/resid/2001-2002/fooali_indexe.shtml#1 (accessed on 15 August 2005).
Carvalhaes G.K., Brooks P., Marques C.G., Azevedo J.A., Machado M.C. & Azevedo G.C. (2002). - Lime as the source of PCDD/F contamination in citrus pulp pellets from Brazil and status of the monitoring program. Chemosphere, 46 (9-10), 1413-1416.
Center for Disease Control and Prevention (1988). - Organophosphate toxicity associated with flea-dip products - California. MMWR, 37, 329-336.
Chandelier A., Michelet J.Y., Tangni E.K., Baert K., Moons E. & Vinkx C. (2004). - Mycotoxins survey in Belgium and toxigenic fusarium in Belgian wheat. In An overview on toxigenic fungi and mycotoxins in Europe (A. Logrieco & A. Visconti, eds). Kluwer Academic Publishers, Dordrecht, Netherlands, 11-32.
Cobb S.P., Hogg R.A., Challoner D.J., Brett M.M., Livesey R.T., Sharpe R.T. & Jones T.O. (2002). - Suspected botulism in dairy cows and its implications for the safety of human food. Vet. Rec., 150, 5-8.
Corpet D.E. & Lumeau S. (1989). - Effect of low levels of antimicrobials on drug resistant populations of intestinal bacteria in gnotobiotic mice. In Rational view of antimicrobials residues: an assessment of human safety (J.P. Raynaud, ed.). Paul Parey, Berlin, 75.
Creppy E.E. (2002). - Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett., 127, 19-28.
De Kok T.M.C.M. & van Maanen J.M.S. (2000). - Evaluation of fecal mutagenicity and colorectal cancer risk. Mutat. Res., 463, 53-101.
Debongnie P., Hallaux B., Etienne F. & Pussemier L. (2000). - Environmental PCB contaminations. In Proc. 8th Annual Meeting of the Flemish Society for Veterinary Epidemiology and Economics, 26 October, Brussels. VEE, Brussels, 72-73.
Dementi B. (1994). - Ocular effects of organophosphates: a historical perspective of Saku disease. J. appl. Toxicol., 14, 119-129.
Dowd P.F. (1998). - Involvement of arthropods in the establishment of mycotoxigenic fungi under field conditions. In Mycotoxins in agriculture and food safety (K.K. Sinha & D. Bhatnagar, eds). Marcel Dekker, New York, 1307-1350.
Dragacci S., Grosso F., Pfauwathel-Marchond N., Fremy J.-M., Venant A. & Lombard B. (2002). - Proficiency testing for the evaluation of the ability of European Union-National Reference laboratories to determine aflatoxin M1 in milk at levels corresponding to the new European Union legislation. Food Addit. Contam., 18 (5), 405-415.
Drotman D.P., Baxter P.J., Liddle J.A., Brokopp C.D. & Skinner M.D. (1983). - Contamination of the food chain by polychlorinated biphenyls from a broker transformer. Am. J. public Hlth, 73, 290-292.
Dudka S. & Miller W.P. (1999). - Accumulation of potentially toxic elements in plants and their transfer to human food chain. J. environ. Sci. Hlth B, 34 (4), 681-708.
Environmental Protection Agency (1999). - The inventory of sources of dioxin in the United States. Exposure analysis and risk characterization group, National Center for Environment Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, DC. Available at: http://www.epa.gov/ncea/diox.htm (accessed on 15 August 2005).
Environmental Protection Agency (2000). - Guidance for assessing chemical contaminant data for use in fish advisories, Vol. 1. Fish sampling and analysis, 3rd Ed. EPA 823-R-95-007. Office of Water, Washington, DC.
Environmental Protection Agency (2000). - Guidance for assessing chemical contaminant data for use in fish advisories, Vol. 2. Risk assessment and fish consumption limits. United States Environmental Protection Agency, Washington, DC, 3rd Ed. Available at: http://www.epa.gov/ost/fishadvice/volume2/index.html (accessed on 15 August 2005).
European Commission (1996). - Council Directive 96/23/EC of 29 April on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decisions 89/187/EEC and 91/664/EEC. Off. J. Eur. Communities, L125, 10-32.
European Commission (1998). - Directive 98/8/EC of the European Parliament and of the Council of 16 February - concerning the placing of biocidal products on the market. Off. J. Eur. Communities, L123, 1-63.
European Commission (1999). - Compilation of EU dioxin exposure and health data, summary report. European Commission and United Kingdom (Department of the Environment, Transport and Regions). Available at: http://europa.eu.int/ comm/environment/dioxin/pdf/summary.pdf (accessed on 15 August 2005).
European Commission (2001). - Opinion of the Scientific Committee on Food on the risk assessment of dioxins and dioxin-like PCBs in food adopted on 30 May. Update based on new scientific information available since the adoption of the SCF opinion of 22 November 2000. European Commission, Health and Consumer Protection Directorate-General, Brussels. Available at: http://europa.eu.int/ comm/food/fs/sc/scf/out90_en.pdf (accessed on 15 August 2005).
European Commission (2002). - Decision (CE) No. 2002/657 of 12 August implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off. J. Eur. Communities, L221, 8-36.
European Commission (2002). - Final report of a mission carried out in Germany from 19 to 23 August in order to evaluate the relevant control systems in place, in the light of the recent findings of nitrofen in food and feedingstuffs. Document DG(SANCO)/8686/2002 - MR Final. Health and Consumer Protection Directorate-General, Brussels.
European Commission (2004). - Rapid alert system for food and feed. Annual report on the functioning of the RASFF 2004. Health and Consumer Protection Directorate-General, European Commission, Brussels.
European Commission (2004). - Regulation (EC) No. 882/2004 of the European Parliament and of the Council of 29 April on official controls performed to ensure the verification of compliance with feed and food law, animal health and animal welfare rules. Off. J. Eur. Communities, L165, 1-141.
European Commission (2005). - Decision (EEC) No. 34/2005 of 11 January laying down harmonised standards for the testing for certain residues in products of animal origin imported from third countries. Off. J. Eur. Communities, L16, 61-63.
European Council (1987). - Directive (EEC) No. 87/181 of 9 March amending the Annex to Directive 79/117/EEC prohibiting the placing on the market and use of plant protection products containing certain active substances. Off. J. Eur. Communities, L71, 33.
European Food Safety Authority (EFSA) (2004). - Methodologies and principles for setting tolerable intake levels for dioxins, furans and dioxin-like PCBs. Summary report of the EFSA scientific colloquium, 28-29 June, Brussels. EFSA, Parma.
European Parliament and Council (2002). - Regulation (EC) No. 178/2002 of 28 January laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Off. J. Eur. Communities, L31, 1-24.
Fisher S.W. (1995). - Mechanisms of bioaccumulation in aquatic systems. In Reviews of environmental contamination and toxicology (G.W. Ware, ed.), Vol. 142. Springer, New York, 87-118.
Food and Agriculture Organization (FAO) (1997). - Agriculture food and nutrition for Africa: a resource book for teachers of agriculture. FAO, Rome.
Food and Agriculture Organization (2005). - Food contaminants and residue information system. Joint FAO/IAEA Programme, nuclear techniques in food and agriculture, infocrisis. Available at: http://infocris.iaea.org/en/default.htm (accessed on 15 August 2005).
Food and Agriculture Organization (2005). - List of pesticides residues in food: maximum residue limits. Available at: http://faostat.fao.org/faostat/ pestdes/jsp/pest_q-f.jsp (accessed on 15 August 2005).
Fraser C.M., Bergeron J.A., Mays A. & Aiello S.E. (eds) (1996). - Toxicologie. In Manuel vétérinaire Merck, 1st Ed. Editions d'Après, Paris, 486-541.
Fries G.F. (1995). - A review of the significance of animal food products as potential pathways of human exposures to dioxins. J. Anim. Sci., 73 (6), 1639-1650.
Fries G.F. & Paustenbach D.J. (1990). - Evaluation of potential transmission of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-contaminated incinerator emissions to humans via foods. J. Toxicol. environ. Hlth, 29 (1), 1-43.
Fuhrmann T. (1991). - Overview of residue concerns of the dairy industry. J. Am. vet. med. Assoc., 198, 836-837.
Gilbert R.J., Hobbs G., Murray C.K., Cruickshank J.G. & Young S.E. (1980). - Scombrotoxic fish poisoning: features of the first 50 incidents to be reported in Britain (1976-1979). Br. med. J., 281, 71-72.
Gillespie I.A., Adak G.K., O'Brien S.J., Brett M.M. & Bolton F.J. (2001). - General outbreaks of infectious intestinal disease associated with fish and shellfish, England and Wales, 1992-1999. Communic. Dis. public Hlth, 4, 117-123.
Gloyd J.S. (1990). - Safe levels of antimicrobial residues in milk announced by FDA. J. Am. vet. med. Assoc., 197, 815.
Gorris L. (2005). - Food safety objective: an integral part of food chain management. Food Control, 16, 801-809.
Guo X., Longnecker M.P. & Michalek J.E. (2001). - Relation of serum tetrachlorodibenzo-p-dioxin concentration to diet among veterans in the Air Force Health Study with background-level exposure. J. Toxicol. environ. Hlth, 63, 159-172.
Hamann J., Tolle A. & Heeschen W. (1979). - Antibiotics and sulphonamides: residues in milk of treated cows and its products. Doc. Int. Dairy Fed., Brussels, 113, 43-56.
Harris B. & Staples C.R. (1992). - The problems of mycotoxins in dairy cattle rations. Institute of Food and Agricultural Sciences, Florida. Available at: http://edis.ifas.ufl.edu/BODY_DS152 (accessed on 15 August 2005).
Hellman B. & Laryea D. (1990). - Inhibitory action of benzimidazole fungicides on the in vivo incorporation of [3H]thymidine in various organs of the mouse. Food chem. Toxicol., 28, 701-706.
Hodgson E., Mailman R.B. & Chambers J.E. (1988). - Dictionary of toxicology, 1st Ed. Macmillan, London.
Horowitz B.Z. (2005). - Botulinum toxin. Crit. Care Clin., 21 (4), 825-839.
Huwe J.K., Davison K., Feil V.J., Larsen G., Lorentzen M., Zaylskie R. & Tiernan T.O. (2004). - Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in cattle raised at agricultural research facilities across the USA and the influence of pentachlorophenol-treated wood. Food Addit. Contam., 21 (2), 182-194.
International Agency for Research on Cancer (IARC) (1983). - Polynuclear aromatic compounds. Part 1. Chemical environment and experimental data. IARC Monograph, Vol. 32. IARC, Lyons. Available at: http://monographs.iarc.fr/ (accessed on 15 August 2005).
International Agency for Research on Cancer (IARC) (1984). - Polynuclear aromatic compounds. Part 3. Industrial exposures in aluminium products, coal gasification, coke production, and iron and steel founding. IARC Monograph, Vol. 34. IARC, Lyons. Available at: http://monographs.iarc.fr/ (accessed on 15 August 2005).
International Agency for Research on Cancer (IARC) (1987). - Working Group on the evaluation of carcinogenic risks to humans, overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1-42. IARC monographs on the evaluation of carcinogenic risks to humans, Supplement 7. IARC, Lyons. Available at: http://monographs.iarc.fr/ (accessed on 15 August 2005).
International Agency for Research on Cancer (IARC) (2002). - Aflatoxins. IARC Monograph, Vol. 82. IARC, Lyons.
International Programme on Chemical Safety (2005). - Disinfectants and disinfectant by-products. World Health Organization, Geneva.
Ishikawa S. (1973). - Chronic optico-neuropathy due to environmental exposure of organophosphale pesticides (Saku disease): clinical and experimental study. Nippon Ganka Gakkai Zasshi, 77, 1835-1886.
Jeyaretnam J. & Jones H. (2000). - Physical, chemical and biological hazards in veterinary practice. Aust. vet. J., 78 (1), 751-758.
Joint Food and Agriculture Organization/World Health Organization (WHO) Expert Committee on Food Additives (.1991). - Toxicological evaluation of certain veterinary drug residues in food. International Programme on Chemical Safety/WHO. WHO Food Additives Series 27. WHO, Geneva.
Joint Food and Agriculture Organization/World Health Organization (WHO) Expert Committee on Food Additives (2002). - Polychlorinated dibenzodioxins, polychlorinated dibenzofurans, and coplanar polychlorinated biphenyls. WHO Food Additives Series 48. WHO, Geneva. Available at: http://www.inchem.org/documents/ jecfa/jecmono/v48je20. htm (accessed on 15 August 2005).
Kavlock R.J., Daston G.P., De Rosa C., Fenner-Crisp P., Gray L.E., Kaattari S., Lucier G., Luster M., Mac M.J., Maczka C., Miller R., Moore J., Rolland R., Scott G., Sheehan D.M., Sinks T. & Tilson H.A. (1996). - Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the US EPA-sponsored workshop. Environ. Hlth Perspect., 104, 715-810.
Kirrane E., Hoppin J.A., Kamel F., Umbach D.M., Boyes W.K., DeRoos A.J., Alavanja M. & Sandler D.P. (2005). - Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health study. Am. J. Epidemiol., 161, 1020-1029.
Kogevinas M. (2001). - Human health effects of dioxins: cancer, reproductive and endocrine system effects. Hum. Reprod., 7 (3), 331-339.
Kong K.Y., Cheung K.C., Wong C.K.C. & Wong M.H. (2005). - The residual dynamic of polycyclic aromatic hydrocarbons and organochlorine pesticides in fishponds of the Pearl River delta, South China. Water Res. (Oxford), 39, 1831-1843.
Lake J.-L., Mckinney R., Lake C.A., Osterman F.A. & Heltshe J. (1995). - Comparisons of patterns of polychlorinated biphenyl congeners in water, sediment and indigenous organisms from New Bedford Harbour, Massachusetts. Arch. environ. Contam. Toxicol., 29, 207-220.
Langley R., Pryor W. & O'Brian K. (1995). - Health hazards among veterinarians: a survey and review of the literature. J. Agromed., 2, 23-52.
Liem A.K., Furst P. & Rappe C. (2000). - Exposure of populations to dioxins and related compounds. Food Addit. Contam., 17 (4), 241-259.
Lievaart J.J., Noordhuizen J.P.T.M., van Beek E., van der Beek C., van Risp A., Schenkel J. & van Veersen J. (2005). - The hazard analysis critical control point's (HACCP) concept as applied to some chemical, physical and microbiological contaminants of milk on dairy farms. A prototype. Vet. Q., 27 (1), 21-29.
Lipp E.K. & Rose J.B. (1997). - The role of seafood in foodborne diseases in the United States of America. In Contamination of animal products: prevention and risks for public health. Rev. sci. tech. Off. int. Epiz., 16 (2), 620-640.
Lopez C.E., Ramos L.L., Ramadan S.S. & Bulacio L.C. (2003). - Presence of aflatoxin M1 in milk for human consumption in Argentina. Food Control, 14, 31-34.
Maghuin-Rogister G., Delaunois A., De Pauw E. & Gustin P. (1999). - La pollution de la chaîne alimentaire par la dioxine. Ann. Méd. vét., 143, 379-392.
Maita K., Tsuda S. & Shirasu Y. (1991). - Chronic toxicity studies with thiram in Wistar rats and beagle dogs. Fundament. appl. Taxicol., 16, 667-686.
Mann P.C. (1997). - Selected lesions of dioxins in laboratory rodents. Toxicol. Pathol., 25, 72-79.
McEwen S.A. & McNab W.B. (1997). - Contaminants of non-biological origin in foods from animals. In Contamination of animal products: prevention and risks for public health. Rev. sci. tech. Off. int. Epiz., 16 (2), 684-693.
McGregor D.B., Partensky C., Wilbourn J. & Rice J.M. (1998). - An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ. Hlth Perspect., 106, 755-760.
Milhaud G. (1985). - Chloramphenicol residues and their toxicity. Ann. Rech. vét., 16 (2), 133-148.
Misra U.K., Nag D., Misra N.K., Melra M.K. & Ray P.K. (1985). - Some observations on the macula of pesticides workers. Hum. Toxicol., 4, 135-145.
Moreau F. & Saegerman C. (1990). - La pratique de la désinfection en élevage bovin (première et deuxième parties). Probio-Revue, 13 (3), 257-273.
Murray C.K. & Hobbs G. (1982). - Scombrotoxin and scombrotoxin-like poisoning from canned fish. J. Hyg. (Camb.), 88, 215-220.
Nasreddine L. & Parent-Massin D. (2002). - Food contamination by metals and pesticides in the European Union. Should we worry? Toxicol. Lett., 127, 29-41.
National Food Agency Finland (2005). - Varying species of fish twice a week. Available at: http://www.palvelu.fi/ evi/files/55_519_349.pdf (accessed on 15 August 2005).
Neidert E., Trotman R.B. & Saschenbrecker P.W. (1994). - Levels and incidence of pesticide residues in selected agricultural food commodities available in Canada. J. Assoc. off. anal. Chem., 77, 18-24.
Oliver B.G. & Niimi A.J. (1988). - Trophodynamic analysis of polychlorinated biphenyl congeners and other chlorinated hydrocarbons in the Lake Ontario ecosystem. Environ. Sci. Technol., 22, 388-397.
Paoliello M.M. & De Capitani E.M. (2005). - Environmental contamination and human exposure to lead in Brazil. Rev. environ. Contam. Toxicol., 184, 59-96.
Paris F., Jeandel C., Servant N. & Sultan C. (2006). - Increased serum estrogenic bioactivity in three male newborns with ambiguous genitalia: a potential consequence of prenatal exposure to environmental endocrine disrupters. Environ. Res., 100 (1), 39-43.
Pedersen D.H., Wilkins III J.R., Bean T.L., Mitchell G.L., Crawford J.M. & Jones L.A. (1999). - Agricultural hazard data from a population-based survey of cash grain farms: Ohio observations. Appl. occupat. environ. Hyg., 14, 299-305.
Peraica M., Radic B., Lucic A. & Pavlovic M. (1999). - Toxic effects of mycotoxins in humans. Bull. WHO, 77, 754-766.
Pfohl-Leszkawicz A. (1999). - Les mycotoxines dans l'alimentation : évaluation et gestion du risque. Lavoisier, Collection Rec&Doc, Paris.
Pussemier L. (2003). - Les contaminations chimiques dans les systèmes de production «bio» et conventionnel. In La sécurité alimentaire. Une approche scientifique. Institut Danone, Brussels, 35-56.
Pussemier L., Mohimont L., Huyghebaert A. & Goeyens L. (2004). - Enhanced levels of dioxins in eggs from free range hens; a fast evaluation approach. Talanta (Oxford), 63, 1274-1276.
Pussemier L., Larondelle Y., van Peteghem C. & Huyghebaert A. (2006). - Chemical safety of conventionally and organically produced foodstuffs: a tentative comparison under Belgian conditions. Food Control, 17, 14-21.
Renwick A.G., Barlow S.M., Hertz-Picciotto I, Boobis A.R., Dybing E., Edler L., Eisenbrand G., Greig J.B., Kleiner J., Lambe J., Müller D.J.G., Smith M.R., Tritscher A., Tuijtelaars S., van den Brandt P.A., Walker R. & Kroes R. (2003). - Risk characterisation of chemicals in food and diet. Food chem. Toxicol., 41, 1211-1271.
Reuter G. (1989). - Requirements for the effectiveness of disinfectants for the food-processing industry. Zentralbl. Bakteriol. Mikrobiol. Hyg., 187, 564-577.
Riley R.T. (1998). - Mechanistic interactions of mycotoxins: theoretical consideration. In Mycotoxins in agriculture and food safety (K.K. Sinha & D. Bhatnagar, eds). Marcel Dekker Inc., New York and Basle, 227-253.
Rodahl K. (1949). - Toxicity of polar bear liver. Nature, 164, 530-531.
Rodricks J.V. (1986). - FDAs ban on the use of DES in meat production: a case study. In Agriculture and human values. Kluwer Academic Publishers B.V., Dordrecht, Boston, New York, London, 10-25.
Ruppol P., Delfosse Ph. & Hornick J.-L. (2004). - La contamination de la filière laitière par les mycotoxines : un risque pour la santé publique en Afrique subsaharienne. Ann. Méd. vét., 148, 141-146.
Saegerman C. (2004). - Epidémiosurveillance des événements rares chez les bovins en Belgique. Thèse de doctorat en Sciences vétérinaires, orientation Médecine vétérinaire, Université de Liège.
Saegerman C., Boelaert F., Van Vlanderen I., Lomba M., Berkvens D., Ermens A., Biron P., Broeckaert F., Bernard A., De Cock A., Demont S., De Poorter G., Torfs B., Robijns J.-M., Monfort V., Vermeersch J.-P. & Lengelé L. (2001). - Monitoring des animaux vivants: exemple d'un échantillonnage pour la détection des PCBs et des dioxines chez les bovins de boucherie en Belgique. Epidémiol. Santé anim., 38, 39-49.
Saegerman C., Berkvens D., Boelaert F., Speybroeck N., Van Vlanderen I., Lomba M., Biront P., Broeckaert F., De Cock A., Mohimont L., Demont S., De Poorter G., Torfs B., Robijns J.-M., Monfort V., Vermeersch J.-P., Lengelé L. & Bernard A. (2002). - Detection of polychlorinated biphenyls and dioxins in Belgian cattle and estimation of the maximal potential exposure in humans through diets of bovine origin. J. Toxicol. environ. Hlth, 65, 1289-1305.
Saegerman C., Claes L., Dewaele A., Desmecht D., Rollin F., Hamoir J., Gustin P., Czaplicki G., Bughin J., Wullepit J., Laureyns J., Roels S., Berkvens D., Vanopdenbosch E. & Thiry E. (2003). - Differential diagnosis of neurologically expressed disorders in Western European cattle. In Risk analysis of prion diseases in animals. Rev. sci. tech. Off. int. Epiz., 22 (1), 83-102.
Schillhorn van Veen T. (2005). - International trade and food safety in developing countries. Food Control, 16, 491-496.
Schwâgele F. (2005). - Traceability from a European perspective. Meat Sci., 71, 164-173.
Seawright A.A. (1982). - Chemical residues in foods of animal origin. In Animal health in Australia, Vol. 2. Chemical and plant poisons. Australian Government Publishing Service, Canberra, 235-244.
Settepani J.A. (1984). - The hazard of using chloramphenicol in food animals. J. Am. vet. med. Assoc., 184 (8), 930-931.
Sharma S.K. & Whiting R.C. (2005). - Methods for detection of Clostridium botulinum toxin in foods. J. Food Protec., 68 (6), 1256-1263.
Smith J.E., Lewis C.W., Anderson J.G. & Solomos G.L. (1994). - Mycotoxins, occurrence and toxicity. In Mycotoxins in human nutrition and health. European Commission, Directorate-General XII, Science, Research and Development, Agro-Industrial Research Division, Brussels, 1-55.
Steenland K., Piacitelli L., Deddens J., Fingerhut M. & Chang L. (1999). - Cancer, heart disease, and diabetes in workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. J. natl. Cancer Inst., 91 (9), 779-786.
Steenland K., Bertazzi P., Baccarelli A. & Kogevinas M. (2004). - Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ. Hlth Perspect., 112 (13), 1265-1268.
Stolker A. & Brinkman U. (2005). - Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals: a review. J. Chromatogr., 1067, 15-53.
Sudlof S.F., Riviere J.E. & Graigmill A.L. (1990). - Food animal residue avoidance databank: trade name file. A comprehensive compendium of dairy cattle drugs, 5th Ed. University of Florida, Gainesville.
Sunesson A.L., Gullberg J. & Blomquist G. (2001). - Airborne chemical compounds on dairy farms. J. environ. Monit., 3 (2), 210-216.
Travis C.C. & Hatterner-Frey H.A. (1991). - Human exposure to dioxin. Sci. total Environ., 104 (1-2), 97-127.
Trotter W.J. & Dickerson R. (1993). - Pesticide residues in composited milk collected through the US pasteurized milk network. J. Assoc. off. anal. Chem., 76 (6), 1220-1225.
United Nations Environment Programmes (1999). - Dioxin and furan inventories: national and regional emissions of PCDD/PCDF. Available at: http://www.chem.unep.ch/pops/pdf/dioxinfuran/difurpt.pdf (accessed on 15 August 2005).
United States Department of Agriculture (2002). - Agricultural chemical usage 2001: dairy cattle and dairy facilities summary. National Agricultural Statistics Service, Washington, DC.
Van Baale M.J., Galland J.C., Hyatt D.R. & Milliken G.A. (2003). - A survey of dairy producer practices and attitudes pertaining to dairy market beef food safety. Food Protec. Trends, 23 (6), 466-473.
Van den Berg M., Birnbaum L., Bosveld A., Brunstrom B., Cook P., Feeley M., Giesy J.P., Hanberg A., Hasegawa R., Kennedy S., Kubiak T., Larsen J.C., van Leeuwen F., Liem K., Nolt C., Peterson R., Poellinger L., Safe S., Schrenk D., Tillitt D., Tysklind M., Younes M., Waern F. & Zacharewski T. (1998). - Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Hlth Perspect., 106 (12), 775.
Van Leeuwen F.X., Feeley M., Schrenk D., Larsen J.C., Farland W. & Younes M. (2000). - Dioxins: WHO'S tolerable daily intake (TDI) revisited. Chemosphere, 40 (9-11), 1095-1101.
Vrijens B., De Henauw S., Dewettinck K., Talloen W., Goeyens L., De Backer G. & Willems J.L. (2002). - Probabilistic intake assessment and body burden estimation of dioxin-like substances in background conditions and during a short food contamination episode. Food Addit. Contam., 19 (7), 687-700.
Waltner-Toews D. & McEwen S.A. (1994). - Insecticide residues in foods of animal origin: a risk assessment. Prev. vet. Med., 20, 179-200.
Waltner-Toews D. & McEwen S.A. (1994). - Residues of antibacterial and antiparasitic drugs in foods of animal origin: a risk assessment. Prev. vet. Med., 20, 219-234.
Waltner-Toews D. & McEwen S.A. (1994). - Residues of hormonal substances in foods of animal origin: a risk assessment. Prev. vet. Med., 20, 235-247.
Weber L.W. & Greim H. (1997). - The toxicity of brominated and mixed-halogenated dibenzo-p-dioxins and dibenzofurans: an overview. J. Toxicol. environ. Hlth, 50 (3), 195-215.
White J., Warrell D., Eddleston M., Currie B.J., White I.M. & Isbister G.K. (2003). - Clinical toxicology: where are we now? J. Toxicol. Clin. Toxicol., 41, 263-276.
Wilkinson T.L., Purschwitz M.A., Schuler R.T. & Skjolaas C.A. (1998). - Farm hazard inspection checklist. University of Wisconsin-Madison Extension, Madison.
Woese K., Lange D., Boess C. & Bögl K.W. (1997). - A comparison of organically and conventionally grown foods: results of a review of the relevant literature. J. Sci. Food Agric., 74, 281-293.
World Health Organization (1998). - Executive summary. In Assessment of health risk of dioxins: re-evaluation of the tolerable daily intake. WHO, Geneva, 1-19.
World Health Organization (WHO) (1999). - Basic food safety for health workers. WHO, Geneva.
World Health Organization (WHO) (2000). - Polychlorinated biphenyls (PCBs). In Air quality guidelines, second edition, Chapter 5.10. WHO Regional Office for Europe, Copenhagen, 22. Available at: http://www.euro.who.int/ document/aiq/5_10pcb.pdf (accessed on 15 August 2005).
World Health Organization (WHO) (2000). - Polychlorinated dibenzodioxins and dibenzofurans. In Air quality guidelines, second edition, Chapter 5.11. WHO Regional Office for Europe, Copenhagen, 21. Available at: http://www.euro.who. int/document/aiq/5_11pcddpcdf.pdf (accessed on 15 August 2005).
World Health Organization (WHO) (2004). - Database of public health chemical incidents: first year pilot phase report. Weekly epidemiol. Rec., 7, 72-76.
World Health Organization (WHO) (2005). - International programme on chemical safety. Chemical safety information from intergovernmental
World Health Organization (WHO) (2005). - PCBs and dioxins in salmon. WHO, Geneva. Available at: http://www.who.int/foodsafety/chem/pcbsalmon/en/ print.html (accessed on 15 August 2005).
Wu M.L., Yang C.C., Yang G.Y., Ger J. & Deng J.F. (1997). - Scombroid fish poisoning: an overlooked marine food poisoning. Vet. hum. Toxicol., 39, 236-241.
Yiannikouris A. & Jouany J.-P. (2002). - Les mycotoxines dans les aliments des ruminants, leur devenir et leurs effets chez l'animal. Prod. anim., 15, 3-16.
Zwietering M. (2005). - Practical considerations on food safety objectives. Food Control, 16, 817-823.