Article (Scientific journals)
Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions
Bearzatto, Bertrand; Servais, Laurent; Roussel, Céline et al.
2006In FASEB Journal, 20, p. 380-382
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Keywords :
calretinin; granule cells; mice
Abstract :
[en] SPECIFIC AIMS Inactivation of gene coding for calretinin, a calcium binding protein acting as a fast calcium buffer, deeply altered the cerebellar physiology leading to motor discoordination. Although mechanistic hypotheses have been proposed to explain these alterations, the widespread expression of calretinin in the whole central nervous system and its expression in several neuronal types in the cerebellar circuitry preclude a precise mechanistic demonstration. The aim of this study was to determine to what extent the expression of calretinin in a specific neuronal cell type, the cerebellar granule cells, contributes to the phenotype detected in calretinin knockout (Cr–/–) mice. To achieve this objective, we constructed transgenic Cr–/– mice exhibiting a selective re-expression of Cr in granule cells (hereafter referred to as Cr-rescue) through the promoter function of the GABAA receptor {alpha}6 subunit gene.
Disciplines :
Biochemistry, biophysics & molecular biology
Genetics & genetic processes
Author, co-author :
Bearzatto, Bertrand;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Servais, Laurent;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Roussel, Céline;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Gall, David;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Baba-Aïssa, Fawzia;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Schurmans, Stéphane  ;  Université Libre de Bruxelles - ULB > IRIBHM, IBMM
de Kerchove d’Exaerde, Alban;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Cheron, Guy;  Université Libre de Bruxelles - ULB > §Laboratory of Movement Biomechanics
Schiffmann, Serge N.;  Université Libre de Bruxelles - ULB > Laboratory of Neurophysiology
Language :
English
Title :
Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions
Publication date :
2006
Journal title :
FASEB Journal
ISSN :
0892-6638
eISSN :
1530-6860
Publisher :
Federation of American Society for Experimental Biology, Bethesda, United States - Maryland
Volume :
20
Pages :
380-382
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 November 2009

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