Melanin-concentrating hormone and immune function

[en] To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence, demonstrating that MCH and its receptors are expressed by cells of the immune system and directly influence the response of these cells in some circumstances. This therefore supports the idea that, as with other peptides, MCH could be considered as a modulator of the immune system. Moreover, we suggest that this could have important implications in several immune-mediated disorders and affirm that there is a clear need for further investigation

Disciplines :

Immunology & infectious disease

Author, co-author :

Lakaye, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique

Coumans, Bernard ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Harray, Sophie ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Grisar, Thierry ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique

Language :

English

Title :

Melanin-concentrating hormone and immune function

Publication date :

2009

Journal title :

Peptides

ISSN :

0196-9781

eISSN :

1873-5169

Publisher :

Elsevier Science, New York, United States - New York

Volume :

Pages :

2076-80

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 November 2009

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Bibliography

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