Utility of Computed Tomographic Angiography for Pulmonary Hypertension Assessment in a Cohort of West Highland White Terriers With or Without Canine Idiopathic Pulmonary Fibrosis
Soliveres, Eugénie; Mc Entee, Kathleen; Couvreur, Thierryet al.
computed tomography angiography; West Highland white terrier; canine idiopathic pulmonary fibrosis; pulmonary trunk; pulmonary hypertension
Abstract :
[en] West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF) are at risk of developing precapillary pulmonary hypertension (PH). In humans, thoracic computed tomography angiography (CTA) is commonly used to diagnose and monitor patients with lower airway diseases. In such patients, CTA helps to identify comorbidities, such as PH, that could negatively impact prognosis. Diameter of the pulmonary trunk (PT), pulmonary trunk-to-aorta ratio (PT/Ao), and right ventricle-to-left ventricle ratio (RV/LV) are CTA parameters commonly used to assess the presence of PH. Pulmonary vein-to-right pulmonary artery ratio (PV/PA) is a new echocardiographic parameter that can be used in dogs to diagnose PH. The primary aim of this study was to evaluate the use of various CTA parameters to diagnose PH. An additional aim was to evaluate the correlation of RV/LV measurements between different CTA planes. CTA and echocardiography were prospectively performed on a total of 47 WHWTs; 22 affected with CIPF and 25 presumed healthy control dogs. Dogs were considered to have PH if pulmonary vein-to-right pulmonary artery ratio (PV/PA) measured on 2D-mode echocardiography was less than to 0.7. WHWTs affected with CIPF had higher PT/Ao compared with control patients. In WHWTs affected with CIPF, PT size was larger in dogs with PH (15.4 mm) compared with dogs without PH (13 mm, p = 0.003). A cutoff value of 13.8 mm predicted PH in WHWTs affected with CIPF with a sensitivity of 90% and a specificity of 87% (AUC = 0.93). High correlations were observed between the different CTA planes of RV/LV. Results suggest that diameter of the PT measured by CTA can be used to diagnose PH in WHWTs with CIPF.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Soliveres, Eugénie ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Imagerie médicale des animaux de compagnie
Fastrès, Aline ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Biologie clinique
Roels, Elodie ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Médecine interne des animaux de compagnie
Merveille, Anne-Christine ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Cardiologie des animaux de compagnie
Tutunaru, Alexandru-Cosmin ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Anesthésiologie et réanimation des animaux de compagnie
Clercx, Cécile ; Université de Liège - ULiège > Dépt d'Ens. et de Clinique des animaux de Compagnie (DCC) > Médecine interne des animaux de compagnie
Bolen, Géraldine ; Université de Liège - ULiège > Département d'Ens. et de Clinique des Equidés (DCE) > Imagerie médicale des équidés
Language :
English
Title :
Utility of Computed Tomographic Angiography for Pulmonary Hypertension Assessment in a Cohort of West Highland White Terriers With or Without Canine Idiopathic Pulmonary Fibrosis
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