[en] OBJECTIVES: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. METHODS: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. RESULTS: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P<0.0001). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. CONCLUSION: The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time.
Disciplines :
Immunology & infectious disease
Author, co-author :
Darcis, Gilles ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses
Bouquegneau, Antoine ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Maes, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico-économiques > Appui à la recherche clinique et biostatistique
Thys, Marie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico-économiques
Henket, Monique ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie
Labye, Florence; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne
Rousseau, Anne-Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Département des soins intensifs
Canivet, Perrine ; Centre Hospitalier Universitaire de Liège - CHU > Département de radiologie
Desir, Colin ; Centre Hospitalier Universitaire de Liège - CHU > Département de radiologie
Calmes, Doriane ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie
Schils, Raphael ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses
De Worm, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses
Léonard, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses
Meunier, Paul ; Centre Hospitalier Universitaire de Liège - CHU > Département de radiologie
Moutschen, Michel ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie
Guiot, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie
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