Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.

Darcis, Gilles; Bouquegneau, Antoine; Maes, Nathalie; Thys, Marie; Henket, Monique; Labye, Florence; Rousseau, Anne-Françoise; Canivet, Perrine; Desir, Colin; Calmes, Doriane; Schils, Raphael; De Worm, Sophie; Léonard, Philippe; Meunier, Paul; Moutschen, Michel; Louis, Renaud; Guiot, Julien

doi:10.1016/j.ijid.2021.07.016

Article (Scientific journals)

Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.

Darcis, Gilles; Bouquegneau, Antoine; Maes, Nathalie et al.

2021 • In International Journal of Infectious Diseases, 109, p. 209-216

Peer reviewed

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https://hdl.handle.net/2268/266516

DOI
10.1016/j.ijid.2021.07.016

PubMed
34273510

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Keywords :

COVID-19; Cohort Studies; Follow-Up Studies; Humans; Prospective Studies; SARS-CoV-2; long COVID; post-COVID; post-acute COVID-19; sequelae

Abstract :

[en] OBJECTIVES: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. METHODS: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. RESULTS: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P<0.0001). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. CONCLUSION: The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time.

Disciplines :

Immunology & infectious disease

Author, co-author :

Darcis, Gilles ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses

Bouquegneau, Antoine ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie

Maes, Nathalie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico-économiques > Appui à la recherche clinique et biostatistique

Thys, Marie ; Centre Hospitalier Universitaire de Liège - CHU > Service des informations médico-économiques

Henket, Monique ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie

Labye, Florence; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne

Rousseau, Anne-Françoise ; Centre Hospitalier Universitaire de Liège - CHU > Département des soins intensifs

Canivet, Perrine ; Centre Hospitalier Universitaire de Liège - CHU > Département de radiologie

Desir, Colin ; Centre Hospitalier Universitaire de Liège - CHU > Département de radiologie

Calmes, Doriane ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie

More authors (7 more)

Language :

English

Title :

Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.

Publication date :

2021

Journal title :

International Journal of Infectious Diseases

ISSN :

1201-9712

eISSN :

1878-3511

Volume :

109

Pages :

209-216

Peer reviewed :

Peer reviewed

Commentary :

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since 29 December 2021

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