Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit-A Monocentric Retrospective Observational Study.

Gregoire, Emilien; Pirotte, Benoit François; Moerman, Filip; Altdorfer, Antoine; Gaspard, Laura; Firre, Eric; Moonen, Martial; Fraipont, Vincent; ERNST, Marie; DARCIS, Gilles

doi:10.3390/pathogens10111370

Article (Scientific journals)

Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit-A Monocentric Retrospective Observational Study.

Gregoire, Emilien; Pirotte, Benoit François; Moerman, Filip et al.

2021 • In Pathogens (Basel, Switzerland), 10 (11)

Peer reviewed

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https://hdl.handle.net/2268/266056

DOI
10.3390/pathogens10111370

PubMed
34832526

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Keywords :

COVID-19-associated pulmonary aspergillosis (CAPA); bronchoalveolar lavage (BAL); coronavirus disease 2019 (COVID-19); galactomannan (GM); intensive care unit (ICU); invasive pulmonary aspergillosis (IPA)

Abstract :

[en] Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is an increasingly recognized complication of COVID-19 and is associated with significant over-mortality. We performed a retrospective monocentric study in patients admitted to the intensive care unit (ICU) for respiratory insufficiency due to COVID-19 from March to December 2020, in order to evaluate the incidence of CAPA and the associated risk factors. We also analysed the diagnostic approach used in our medical centre for CAPA diagnosis. We defined CAPA using recently proposed consensus definitions based on clinical, radiological and microbiological criteria. Probable cases of CAPA occurred in 9 out of 141 patients included in the analysis (6.4%). All cases were diagnosed during the second wave of the pandemic. We observed a significantly higher realization rate of bronchoalveolar lavage (BAL) (51.1% vs. 28.6%, p = 0.01) and Aspergillus testing (through galactomannan, culture, PCR) on BAL samples during the second wave (p < 0.0001). The testing for Aspergillus in patients meeting the clinical and radiological criteria of CAPA increased between the two waves (p < 0.0001). In conclusion, we reported a low but likely underestimated incidence of CAPA in our population. A greater awareness and more systematic testing for Aspergillus are necessary to assess the real incidence and characteristics of CAPA.

Disciplines :

Immunology & infectious disease

Author, co-author :

Gregoire, Emilien

Pirotte, Benoit François

Moerman, Filip

Altdorfer, Antoine

Gaspard, Laura

Firre, Eric

Moonen, Martial

Fraipont, Vincent

ERNST, Marie ; Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique

DARCIS, Gilles ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service des maladies infectieuses - médecine interne

Language :

English

Title :

Incidence and Risk Factors of COVID-19-Associated Pulmonary Aspergillosis in Intensive Care Unit-A Monocentric Retrospective Observational Study.

Publication date :

2021

Journal title :

Pathogens (Basel, Switzerland)

ISSN :

2076-0817

eISSN :

2076-0817

Volume :

Issue :

Peer reviewed :

Peer reviewed

Available on ORBi :

since 14 December 2021

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