Article (Scientific journals)
Cardiac Biomarkers and Prediction of Early Outcome After Heart Valve Surgery: A Prospective Observational Study.
Wozolek, Aaron; Jaquet, Oceane; Donneau, Anne-Françoise et al.
2022In Journal of Cardiothoracic and Vascular Anesthesia
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Keywords :
GDF15; NT-proBNP; biomarker; galectin-3; heart valve; soluble ST2; surgery
Abstract :
[en] OBJECTIVES: Circulating cardiac biomarkers may improve the prediction of long-term outcomes after cardiac surgery. The authors sought to assess if cardiac biomarkers also help better predict short-term morbidity. DESIGN: Prospective observational study. SETTING: Single academic hospital. PARTICIPANTS: A total of 250 patients undergoing aortic or mitral valve surgery with or without associated coronary artery bypass grafts. INTERVENTION: None MEASUREMENT AND MAIN RESULTS: Relationships between preoperative plasma concentrations of four cardiac biomarkers (sST2, Galectin-3, GDF-15, and NT-proBNP) and postoperative outcome were assessed using logistic regressions and Cox proportional hazards models. The primary outcome was a composite of 30-day mortality, an inotropic support longer than 48 hours and an initial length of stay in the intensive care >five days. Secondary outcome measures were postoperative acute kidney injury, inotropic support duration, lengths of intensive care unit and hospital stays, and 30-day and one-year mortality. No association was observed between any of the four cardiac biomarkers and the primary outcome. The preoperative levels of Galectin-3 (hazard ratio = 1.2; p < 0.001) and sST2 (hazard ratio = 1.01, p < 0.001) were significantly associated with one-year survival, and their addition to the EuroSCORE II significantly improved the prediction of one-year mortality (p < 0.001). Similarly, Galectin-3 was associated with postoperative acute kidney injury (odds ratio = 1.15, p = 0.001) and improved the prediction of this complication when added to the EuroSCORE II (p = 0.002). CONCLUSIONS: These results suggested that the ability of cardiac biomarkers to predict short-term outcome after cardiac surgery, though of interest, appears limited. Conversely, cardiac biomarkers may have the potential to refine the prediction of long-term outcome. Admittedly, all positive results were obtained on secondary outcomes and must be regarded with caution.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Wozolek, Aaron 
Jaquet, Oceane 
Donneau, Anne-Françoise 
Lancellotti, Patrizzio  
Le Goff, Caroline  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Radermecker, Marc ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie humaine
Lavigne, Jean-Paul 
Durieux, Rodolphe  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Roediger, Laurence 
Senard, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Hans, Grégory  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
More authors (5 more) Less
Language :
English
Title :
Cardiac Biomarkers and Prediction of Early Outcome After Heart Valve Surgery: A Prospective Observational Study.
Publication date :
2022
Journal title :
Journal of Cardiothoracic and Vascular Anesthesia
ISSN :
1053-0770
eISSN :
1532-8422
Publisher :
W. B. Saunders Co., United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2021 Elsevier Inc. All rights reserved.
Available on ORBi :
since 07 December 2021

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