Article (Scientific journals)
Immunity and Breast Cancer: Focus on Eosinophils
Poncin, Aurélie; Onesti, Concetta Elisa; JOSSE, Claire et al.
2021In Biomedicines, 9 (9), p. 1087
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Keywords :
eosinophils; breast cancer; tumor immunity
Abstract :
[en] The role of eosinophils, a cell type involved in the immune response to parasitic infections and allergies, has been investigated in different cancer types, in both tumor tissue and at the circulating level. Most studies showed a role mainly in conjunction with immunotherapy in melanomas and lung tumors, while few data are available in breast cancer. In this review, we summarize literature data on breast cancer, showing a prognostic role of circulating eosinophil counts as well as of the presence of tumor tissue infiltration by eosinophils. In particular, some studies showed an association between a higher circulating eosinophil count and a good prognosis, as well as an association with response to neoadjuvant chemotherapy in hormone receptor-negative/HER2-positive and in triple negative breast cancer. Several mechanistic studies have also been conducted in in vivo models, but the exact mechanism by which eosinophils act in the presence of breast cancer is still unknown. Further studies on this subject are desirable, in order to understand their role at the cellular level, identify related biomarkers and/or possibly search for new therapeutic targets.
Disciplines :
Oncology
Author, co-author :
Poncin, Aurélie ;  Centre Hospitalier Universitaire de Liège - CHU > Département des sciences cliniques > Service d'oncologie médicale
Onesti, Concetta Elisa 
JOSSE, Claire  ;  Centre Hospitalier Universitaire de Liège - CHU > Département des sciences cliniques > Service d'oncologie médicale
Boulet, Delphine 
Thiry, Jérôme 
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Jerusalem, Guy  ;  Université de Liège - ULiège > Département des sciences cliniques > Oncologie
Language :
English
Title :
Immunity and Breast Cancer: Focus on Eosinophils
Publication date :
August 2021
Journal title :
Biomedicines
eISSN :
2227-9059
Publisher :
MDPI AG, Switzerland
Volume :
9
Issue :
9
Pages :
1087
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 September 2021

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