Profil

Josse Claire

GIGA Cancer - Human Genetics

See author's contact details
ORCID
0000-0003-0315-3718
Main Referenced Co-authors
Bours, Vincent  (50)
Jerusalem, Guy  (30)
Freres, Pierre  (14)
Poulet, Christophe  (14)
Fasquelle, Corinne  (11)
Main Referenced Keywords
breast cancer (10); Rwanda (5); cancer (4); Animals (3); BRCA (3);
Main Referenced Unit & Research Centers
Giga-Genetics - ULiège [BE] (5)
GIGA‐R - Giga‐Research - ULiège [BE] (4)
Giga-Cancer - ULiège [BE] (4)
Human Genetics (2)
GIGA-Human Genetics (1)
Main Referenced Disciplines
Oncology (24)
Genetics & genetic processes (16)
Biochemistry, biophysics & molecular biology (5)
Life sciences: Multidisciplinary, general & others (4)
Computer science (2)

Publications (total 57)

The most downloaded
1435 downloads
JERUSALEM, G., COLLIGNON, J., Josse, C., SCHROEDER, H., RORIVE, A., FRERES, P., LAMBERT, F., KOOPMANSCH, B., PONCIN, A., & BOURS, V. (2015). Cancer du sein : de la thérapie ciblée à la médecine personnalisée. Revue Médicale de Liège, 70 (5-6), 269-276. https://hdl.handle.net/2268/184321

The most cited

480 citations (Scopus®)

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x https://hdl.handle.net/2268/260539

Poulet, C.* , Debit, A.* , Josse, C., Jerusalem, G., Azencott, C.-A., Bours, V., & Van Steen, K. (2023). Assessing Random Forest self-reproducibility for optimal short biomarker signature discovery. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/303314. doi:10.1101/2023.03.29.534695
* These authors have contributed equally to this work.

BOEMER, F., JOSSE, C., LUIS, G., Di Valentin, E., Thiry, J., CELLO, C., CABERG, J.-H., DADOUMONT, C., HARVENGT, J., Lumaka, A., BOURS, V., & DEBRAY, F.-G. (18 February 2022). Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy. International Journal of Molecular Sciences, 23 (4), 2253. doi:10.3390/ijms23042253
Peer Reviewed verified by ORBi

Bhardwaj, A., Josse, C., VAN DAELE, D., Poulet, C., Chavez, M., Struman, I., & Van Steen, K. (2022). Deeper insights into long-term survival heterogeneity of Pancreatic Ductal Adenocarcinoma (PDAC) patients using integrative individual-and group-level transcriptome network analyses. Scientific Reports, 12 (11027). doi:10.1038/s41598-022-14592-1
Peer Reviewed verified by ORBi

Freire, M. V., MARTIN, M., Thissen, R., Van Marcke, C., SEGERS, K., SEPULCHRE, E., LEROI, N., LETE, C., FASQUELLE, C., Radermacher, J., Gokburun, Y., COLLIGNON, J., Sacré, A., JOSSE, C., PALMEIRA, L., & BOURS, V. (2022). Case Report Series: Aggressive HR Deficient Colorectal Cancers Related to BRCA1 Pathogenic Germline Variants. Frontiers in Oncology, 12, 835581. doi:10.3389/fonc.2022.835581
Peer Reviewed verified by ORBi

Thissen, R., ARTESI, M., Durkin, K., JOSSE, C., PALMEIRA, L., & BOURS, V. (24 December 2021). Comprehensive detection of homologous recombination deficiency by Nanopore sequencing [Poster presentation]. GIGA cancer day, Liège, Belgium.

Poncin, A., Onesti, C. E., JOSSE, C., Boulet, D., Thiry, J., Bours, V., & Jerusalem, G. (August 2021). Immunity and Breast Cancer: Focus on Eosinophils. Biomedicines, 9 (9), 1087. doi:10.3390/biomedicines9091087
Peer Reviewed verified by ORBi

Uyisenga, J. P.* , Debit, A.* , Poulet, C., Frères, P., Poncin, A., Thiry, J., Mutesa, L., Jerusalem, G., Bours, V.* , & JOSSE, C.*. (03 June 2021). Differences in plasma microRNA content impair microRNA-based signature for breast cancer diagnosis in cohorts recruited from heterogeneous environmental sites. Scientific Reports, 11 (1), 11698. doi:10.1038/s41598-021-91278-0
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Niemi, M., Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., ... HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x
Peer Reviewed verified by ORBi

Onesti, C. E., JOSSE, C., Boulet, D., Bours, V., & JERUSALEM, G. (2020). High plasmatic levels of IL-4 and IL- 13 are associated with recurrence and worse survival in breast cancer. Tumori Journal.
Peer Reviewed verified by ORBi

ONESTI, C. E., JOSSE, C., Beaumecker, B., Boulet, D., Thiry, J., BOURS, V., & JERUSALEM, G. (2020). The relative eosinophil count in breast cancer as an emerging prognostic biomarker. European Journal of Cancer. doi:10.1016/S0959-8049(20)30766-8
Peer reviewed

Uyisenga, J., Butera, Y., Debit, A., JOSSE, C., Ainhoa, C. C., Karinganire, E., Cyuzuzo, A. P., Umurungi, N., Kalinijabo, Y., Uwimana, S., Mutesa, L., & Bours, V. (2020). Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages. Hormones and Cancer. doi:10.1007/s12672-020-00393-3
Peer reviewed

Uyisenga, J., SEGERS, K., Lumaka, A. Z., Mugenzi, P., FASQUELLE, C., Boujemla, B., JOSSE, C., Mutesa, L., & Bours, V. (2020). Screening of germline mutations in young Rwandan patients with breast cancers. Molecular Genetics and Genomic Medicine. doi:10.1002/mgg3.1500
Peer Reviewed verified by ORBi

Jacquinet, A., Boujemla, B., FASQUELLE, C., Thiry, J., JOSSE, C., Lumaka, A., Brischoux-Boucher, E., Dubourg, C., David, V., Pasquier, L., Lehman, A., Morcel, K., Guerrier, D., & Bours, V. (2020). GREB1L variants in familial and sporadic hereditary urogenital adysplasia and Mayer-Rokitansky-Kuster-Hauser syndrome. Clinical Genetics, 98 (2), 126-137. doi:10.1111/cge.13769
Peer Reviewed verified by ORBi

ONESTI, C. E., JOSSE, C., Boulet, D., Thiry, J., Beaumecker, B., BOURS, V., & JERUSALEM, G. (2020). Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse. Oncoimmunology. doi:10.1080/2162402X.2020.1761176
Peer Reviewed verified by ORBi

Uyisenga, J., SEGERS, K., Butera, Y., Musoni, E., Uwimana, S., Habanabakize, T., Ruzigana, G., Mugenzi, P., JOSSE, C., BOURS, V., & Mutesa, L. (04 December 2019). Primary sarcoma of the breast in the young Rwandan females. Breast Cancer Reports, 6 (2). doi:10.7243/2057-1631-6-2
Peer reviewed

Uyisenga, J., SEGERS, K., Lumaka Zola, A., Mugenzi, P., Boujemla, B., JOSSE, C., Mutesa, L., & BOURS, V. (26 September 2019). Germline mutations in young Rwandan with breast cancers [Paper presentation]. The Joint Minimally Invasive Surgery (MIS) & 3rd Rwanda Biotechnology Conference, Kigali, Rwanda.

ONESTI, C. E., BOEMER, F., JOSSE, C., LEDUC, S., Poulet, C., BOURS, V., & JERUSALEM, G. (2019). Tryptophan catabolism differentiates breast cancer patients from healthy controls but does not predict outcome. Annals of Oncology.
Peer Reviewed verified by ORBi

Latge, G., Poulet, C., JOSSE, C., JERUSALEM, G., & Bours, V. (15 March 2019). Role of DNA methylation in INK4a-ARF-INK4b locus expression in breast cancer [Poster presentation]. 19th Meeting of the Belgian Society of Human Genetics, Liège, Belgium.

Debit, A., Poulet, C., JOSSE, C., Azencott, C.-A., Jerusalem, G., Van Steen, K., & BOURS, V. (15 March 2019). TOWARDS AN ACCURATE CANCER DIAGNOSIS MODELIZATION:COMPARISON OF RANDOM FOREST STRATEGIES [Poster presentation]. 19th BeSHG meeting 15th March 2019 Liege, Belgium, Liege, Belgium.

ONESTI, C. E., BOEMER, F., JOSSE, C., LEDUC, S., BOURS, V., & JERUSALEM, G. (2019). Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy. Journal of Translational Medicine, 17, 239. doi:10.1186/s12967-019-1984-2
Peer Reviewed verified by ORBi

Debit, A., Poulet, C., JOSSE, C., Van Steen, K., JERUSALEM, G., Bours, V., & Azencott, C.-A. (05 October 2018). Towards an accurate cancer diagnosis modelization: Comparison of Random Forest strategies [Poster presentation]. 5th conference Bioinformatics for young international researchers expo byteMAL 2018, Liege, Belgium.

Uyisenga, J., SEGERS, K., Lumaka Zola, A., Mugenzi, P., FASQUELLE, C., Boujemla, B., JOSSE, C., Mutesa, L., & Bours, V. (20 September 2018). Screening of germline mutations in young Rwandan with breast cancer [Paper presentation]. Joint 11th Conference of African Society of Human Genetics (AfSHG)& 12th H3 Africa Consortium Meeting, Kigali, Rwanda.

ONESTI, C. E., JOSSE, C., Poncin, A., FRERES, P., Poulet, C., BOURS, V., & JERUSALEM, G. (2018). Predictive and prognostic role of peripheral blood eosinophil count in triple-negative and hormone receptor-negative/HER2-positive breast cancer patients undergoing neoadjuvant treatment. Oncotarget. doi:10.18632/oncotarget.26120
Peer Reviewed verified by ORBi

Latgé, G., JOSSE, C., Poulet, C., Bours, V., & Jerusalem, G. (13 September 2018). Role of DNA methylation in INK4a-ARF-INK4b locus expression in breast cancer [Poster presentation]. GIGA-Cancer DAY, Liege, Belgium.

Debit, A., JOSSE, C., JERUSALEM, G., BOURS, V., & Poulet, C. (13 September 2018). Towards an accurate cancer diagnosis modelization:Comparison of Random Forest strategies [Poster presentation]. JOINT MEETING GIGA-CANCER DAY 2018 / EDT-CANCEROLOGY, Liege, Belgium.

ONESTI, C. E., JOSSE, C., PONCIN, A., FRERES, P., Poulet, C., BOURS, V., & JERUSALEM, G. (13 September 2018). Predictive and prognostic role of peripheral blood eosinophil count in triple negative and hormone receptor negative/HER2 positive breast cancers patients undergoing neoadjuvant treatment [Paper presentation]. GIGA-Cancer Day 2018 / EDT-Cancerology Vascular landscape and (pre)metastatic niche in cancer biology.

Uyisenga, J., SEGERS, K., Lumaka Zola, A., Mugenzi, P., FASQUELLE, C., Boujemla, B., JOSSE, C., Mutesa, L., & Bours, V. (11 September 2018). Germline mutations in young Rwandan with breast cancers [Poster presentation]. GIGA Cancer Day, Liège, Belgium.

Costanza, B., Turtoi, A., Bellahcene, A., Hirano, T., Peulen, O., Blomme, A., Hennequiere, J., MUTIJIMA NZARAMBA, E., Boniver, J., Meuwis, M.-A., JOSSE, C., KOOPMANSCH, B., SEGERS, K., Yokobori, T., Fahmy, K., Thiry, M., COIMBRA MARQUES, C., Garbacki, N., Colige, A., ... Castronovo, V. (2018). Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9 (12), 10665-10680. doi:10.18632/oncotarget.24366
Peer Reviewed verified by ORBi

Latge, G., Poulet, C., Bours, V., JOSSE, C., & Jerusalem, G. (2018). Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers. International Journal of Molecular Sciences, 19 (1). doi:10.3390/ijms19010123
Peer Reviewed verified by ORBi

Freres, P., Bouznad, N., Servais, L., JOSSE, C., Wenric, S., Poncin, A., Thiry, J., Moonen, M., Oury, C., Lancellotti, P., Bours, V., & Jerusalem, G. (2018). Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients. BMC Cancer, 18 (1). doi:10.1186/s12885-018-4015-4
Peer Reviewed verified by ORBi

Debit, A., Wenric, S., JOSSE, C., Van Steen, K., & Bours, V. (May 2017). Normalization and correction for batch effects via RUV for RNA-seq data: practical implications for Breast Cancer Research [Poster presentation]. European Human Genetics Conference ESHG 2017, Copenhagen, Denmark.

Wenric, S., El Guendi, S., CABERG, J.-H., Bezzaou, W., Fasquelle, C., Charloteaux, B., Karim, L., Hennuy, B., FRERES, P., COLLIGNON, J., BOUKERROUCHA, M., SCHROEDER, H., Olivier, F., Jossa, V., JERUSALEM, G., JOSSE, C., & BOURS, V. (May 2017). Transcriptome wide analysis of natural antisense transcripts shows potential role in breast cancer [Poster presentation]. 50th meeting of the European Society of Human Genetics, Copenhagen, Denmark.

Wenric, S.* , Sticca, T.* , CABERG, J.-H., Josse, C., Fasquelle, C., HERENS, C., JAMAR, M., MAX, S., GOTHOT, A., CAERS, J., & Bours, V. (2017). Exome copy number variation detection: Use of a pool of unrelated healthy tissue as reference sample. Genetic Epidemiology, 41, 35-40. doi:10.1002/gepi.22019
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Wenric, S., ElGuendi, S., CABERG, J.-H., Bezzaou, W., Fasquelle, C., Charloteaux, B., Karim, L., Hennuy, B., FRERES, P., COLLIGNON, J., BOUKERROUCHA, M., SCHROEDER, H., OLIVIER, F., Jossa, V., Jerusalem, G., JOSSE, C., & Bours, V. (2017). Transcriptome-wide analysis of natural antisense transcripts shows their potential role in breast cancer. Scientific Reports, 7 (1), 17452. doi:10.1038/s41598-017-17811-2
Peer Reviewed verified by ORBi

BOEMER, F., Fasquelle, C., D'OTREPPE DE BOUVETTE, S., JOSSE, C., DIDEBERG, V., SEGERS, K., GUISSARD, V., CAPRARO, V., Debray, F.-G., & Bours, V. (2017). A next-generation newborn screening pilot study: NGS on dried blood spots detects causal mutations in patients with inherited metabolic diseases. Scientific Reports, 7 (1), 17641. doi:10.1038/s41598-017-18038-x
Peer Reviewed verified by ORBi

Sticca, T., CABERG, J.-H., Wenric, S., Poulet, C., HERENS, C., JAMAR, M., Josse, C., El Guendi, S., MAX, S., BEGUIN, Y., GOTHOT, A., CAERS, J., & Bours, V. (2017). Genomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity. Genes, Chromosomes and Cancer, 56, 18-27. doi:10.1002/gcc.22397
Peer Reviewed verified by ORBi

Josse, C., & Bours, V. (2016). MicroRNAs and Inflammation in Colorectal Cancer. In O. Slaby & G. A. Calin, Non-coding RNAs in Colorectal Cancer (1° éd, pp. 53-69). Switzerland: Springer. doi:10.1007/978-3-319-42059-2_3
Peer reviewed

FRERES, P., PONCIN, A., MOONEN, M., Josse, C., Oury, C., BOURS, V., LANCELLOTTI, P., & JERUSALEM, G. (2016). La cardiotoxicité des traitements anti-cancéreux. Revue Médicale de Liège, 71 (9), 382-387.
Peer reviewed

Freres, P.* , Wenric, S.* , BOUKERROUCHA, M., Fasquelle, C., Thiry, J., Bovy, N., Struman, I., Geurts, P., COLLIGNON, J., SCHROEDER, H., KRIDELKA, F., LIFRANGE, E., Jossa, V., Bours, V.* , Josse, C.* , & JERUSALEM, G.*. (2015). Circulating microRNA-based screening tool for breast cancer. Oncotarget. doi:10.18632/oncotarget.6786
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Boukerroucha, M., Josse, C., SEGERS, K., El Guendi, S., FRERES, P., JERUSALEM, G., & Bours, V. (26 March 2015). BRCA1 germline mutation and glioblastoma development: report of cases. BMC Cancer, 15, 181. doi:10.1186/s12885-015-1205-1
Peer Reviewed verified by ORBi

Boukerroucha, M., Josse, C., El Guendi, S., FRERES, P., Marée, R., Wenric, S., SEGERS, K., COLLIGNON, J., JERUSALEM, G., & BOURS, V. (2015). Genetic study of triple negative breast cancers [Poster presentation]. Impakt Breast Cancer Conference, Brussels, Belgium. doi:10.1093/annonc/mdv116.11

Bovy, N., Blomme, B., Freres, P., Dederen, S., Nivelles, O., Lion, M., Carnet, O., Martial, J., Noël, A., Thiry, M., Jerusalem, G., Josse, C., Bours, V., Tabruyn, S., & Struman, I. (2015). Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer. Oncotarget. doi:10.18632/oncotarget.3520
Peer Reviewed verified by ORBi

JERUSALEM, G., COLLIGNON, J., Josse, C., SCHROEDER, H., RORIVE, A., FRERES, P., LAMBERT, F., KOOPMANSCH, B., PONCIN, A., & BOURS, V. (2015). Cancer du sein : de la thérapie ciblée à la médecine personnalisée. Revue Médicale de Liège, 70 (5-6), 269-276.
Peer reviewed

DEBRAY, F.-G., Stumpfig, C., Vanlander, A. V., DIDEBERG, V., Josse, C., CABERG, J.-H., BOEMER, F., Bours, V., Stevens, R., Seneca, S., Smet, J., Lill, R., & van Coster, R. (2015). Mutation of the iron-sulfur cluster assembly gene IBA57 causes fatal infantile leukodystrophy. Journal of Inherited Metabolic Disease. doi:10.1007/s10545-015-9857-1
Peer Reviewed verified by ORBi

Boukerroucha, M., Josse, C., El Guendi, S., Boujemla, B., Freres, P., Marée, R., Wenric, S., SEGERS, K., COLLIGNON, J., Jerusalem, G., & Bours, V. (2015). Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers. BMC Cancer, 15 (1), 755. doi:10.1186/s12885-015-1740-9
Peer Reviewed verified by ORBi

FRERES, P., JOSSE, C., Bovy, N., Boukerroucha, M., Struman, I., BOURS, V., & JERUSALEM, G. (2014). Neoadjuvant chemotherapy in breast cancer induces miR-34a and miR-122 expression. Journal of Cellular Physiology. doi:10.1002/jcp.24730
Peer Reviewed verified by ORBi

JOSSE, C., Bouznad, N., Geurts, P., Irrthum, A., Huynh-Thu, V. A., Servais, L., Hego, A., Delvenne, P., Bours, V., & Oury, C. (2014). Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 306, 229-43. doi:10.1152/ajpgi.00484.2012
Peer Reviewed verified by ORBi

Wenric, S., Freres, P., Josse, C., Bours, V., & Jerusalem, G. (09 December 2013). A miRNA expression based diagnostic tool for breast cancer using random forests [Poster presentation]. Benelux Bioinformatics Conference 2013.

Wenric, S., JOSSE, C., Fasquelle, C., Poulet, C., Sticca, T., Boukerroucha, M., JERUSALEM, G., & Bours, V. (15 March 2013). Exome sequencing of tumors: relevance in copy-number alteration (CNA) analysis and fixed tissue samples [Poster presentation]. 13th Annual Meeting of the Belgian Society of Human Genetics, Bruxelles, Belgium.

COLLIGNON, J., Struman, I., Tabruyn, S., Josse, C., Boukerroucha, M., JERUSALEM, G., & BOURS, V. (2011). Aspects moléculaires du cancer du sein triple négatif et les implications thérapeutiques. Revue Médicale de Liège, 66 (5-6), 393-396.
Peer reviewed

Josse, C., Schoemans, R., Niessen, N.-A., Delgaudine, M., Hellin, A.-C., Herens, C., Delvenne, P., & Bours, V. (August 2010). Systematic chromosomal aberrations found in murine bone marrow-derived mesenchymal stem cells. Stem Cells and Development, 19 (8), 1167-1173. doi:10.1089/scd.2009.0264
Peer Reviewed verified by ORBi

Schoemans, R., Aigrot, M.-S., Wu, C., Marée, R., Hong, P., Belachew, S., Josse, C., Lubetzki, C., & Bours, V. (2010). Oligodendrocyte development and myelinogenesis are not impaired by high concentrations of phenylalanine or its metabolites. Journal of Inherited Metabolic Disease, 33 (2), 113-20. doi:10.1007/s10545-010-9052-3
Peer Reviewed verified by ORBi

Zeddou, M., Briquet, A., Relic, B., Josse, C., Malaise, M., Gothot, A., Lechanteur, C., & Beguin, Y. (2010). The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood. Cell Biology International, 34 (7), 693-701. doi:10.1042/CBI20090414
Peer Reviewed verified by ORBi

Legssyer, R., Josse, C., Piette, J., Ward, R. J., & Crichton, R. R. (2003). Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine. Journal of Inorganic Biochemistry, 94 (1-2), 36-42. doi:10.1016/S0162-0134(02)00633-5
Peer Reviewed verified by ORBi

JOSSE, C., Boelaert, J. R., Best-Belpomme, M., & Piette, J. (2001). Importance of post-transcriptional regulation of chemokine genes by oxidative stress. Biochemical Journal, 360 (Pt 2), 321-33. doi:10.1042/0264-6021:3600321
Peer Reviewed verified by ORBi

Josse, C., Legrand-Poels, S., Piret, B., Sluse, F., & Piette, J. (1998). Impairment of mitochondrial functions abolishes NF-kappaB activation by an oxidative stress. Free Radical Biology and Medicine.
Peer Reviewed verified by ORBi

JOSSE, C., Legrand-Poels, S., Piret, B., Sluse, F., & Piette, J. (1998). Impairment of the mitochondrial electron chain transport prevents NF-kappa B activation by hydrogen peroxide. Free Radical Biology and Medicine, 25 (1), 104-112. doi:10.1016/S0891-5849(98)00057-4
Peer Reviewed verified by ORBi

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