Article (Scientific journals)
Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study
HUART, Justine; Cirillo, Arianna; Taminiau, Bernard et al.
2021In Metabolites, 11 (5), p. 282
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Keywords :
Metabolomics; hypertension; micribiome
Abstract :
[en] Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called "the dipping profile", has been poorly investigated. Sixteen male volunteers and 10 female partners were subjected to 24 h ambulatory BP monitoring and were categorized in normotensive (NT) versus HT, as well as in dippers versus non-dippers. Nuclear magnetic resonance (NMR)-based metabolomics was performed on stool samples. A 5-year comparative follow-up of BP profiles and stool metabolomes was done in men. Significant correlations between stool metabolome and 24 h mean BP levels were found in both male and female cohorts and in the entire cohort (R2 = 0.72, R2 = 0.79, and R2 = 0.45, respectively). Multivariate analysis discriminated dippers versus non-dippers in both male and female cohorts and in the entire cohort (Q2 = 0.87, Q2 = 0.98, and Q2 = 0.68, respectively). Fecal amounts of acetate, propionate, and butyrate were higher in HT versus NT patients (p = 0.027; p = 0.015 and p = 0.015, respectively), as well as in non-dippers versus dippers (p = 0.027, p = 0.038, and p = 0.036, respectively) in the entire cohort. SCFA levels were significantly different in patients changing of dipping status over the 5-year follow-up. In conclusion, stool metabolome changes upon global and circadian BP profiles in both genders.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
HUART, Justine   ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Cirillo, Arianna  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Taminiau, Bernard  ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
DESCY, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire mycobactérie
SAINT-REMY, Annie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Daube, Georges  ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
KRZESINSKI, Jean-Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
MELIN, Pierrette  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
De Tullio, Pascal  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
JOURET, François   ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
 These authors have contributed equally to this work.
Language :
English
Title :
Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study
Publication date :
29 April 2021
Journal title :
Metabolites
eISSN :
2218-1989
Publisher :
MDPI AG
Volume :
11
Issue :
5
Pages :
282
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 August 2021

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