Biomarkers; Biomarkers, Tumor; Chemistry, Clinical; Humans; Laboratories; Sensitivity and Specificity; Interpretation; Limitations; Perspectives; Single molecule array; Tumor biomarkers
Abstract :
[en] In current practice, the use of circulating oncological biomarkers by clinicians is almost inseparable from cancer patients management. However, the interpretation of the results is not always easy because it is more specific to laboratory medicine and involves notions of peri-analytical orders as well as analytical sensitivity and specificity. In the past, the development of new analytical techniques improved the analytical sensitivity or allowed the implementation of new biomarkers; this observation would still be true today. Mass spectrometry, microRNA assay, or Single Molecule Array (SiMoA) are recent analytical developments with very good analytical performances that could contribute to the improvement of cancer patient management.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Sqalli, Ghali ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
LADANG, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire endocrinologie
Language :
French
Title :
Dosage au laboratoire de chimie clinique des biomarqueurs circulants oncologiques : limites et perspectives.
Alternative titles :
[en] Clinical chemistry laboratory assay of circulating oncology biomarkers : limitations and perspectives
Publication date :
May 2021
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
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