Article (Scientific journals)
Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs
SEYNAEVE, Ysaline; Heylen, Justine; FONTAINE, Corentin et al.
2021In Journal of Clinical Medicine, 10 (13), p. 2774
Peer reviewed
 

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Keywords :
Rapid diagnostic tests; Antigen detection; SARS-CoV-2
Abstract :
[en] (1) Background: In the current context of the COVID-19 crisis, there is a need for fast, easyto- use, and sensitive diagnostic tools in addition to molecular methods. We have therefore decided to evaluate the performance of newly available antigen detection kits in “real-life” laboratory conditions.(2) Methods: The sensitivity and specificity of two rapid diagnostic tests (RDT)—the COVID-19 Ag Respi-Strip from Coris Bioconcept, Belgium (CoRDT), and the coronavirus antigen rapid test cassette from Healgen Scientific, LLC, USA (HeRDT)—were evaluated on 193 nasopharyngeal samples using RT-PCR as the gold standard. (3) Results: The sensitivity obtained for HeRDT was 88% for all collected samples and 91.1% for samples with Ct 31. For the CoRDT test, the sensitivity obtained was 62% for all collected samples and 68.9% for samples with Ct 31. (4) Conclusions: Despite the excellent specificity obtained for both kits, the poor sensitivity of the CoRDT did not allow for its use in the rapid diagnosis of COVID-19. HeRDT satisfied the World Health Organization’s performance criteria for rapid antigen detection tests. Its high sensitivity, quick response, and ease of use allowed for the implementation of HeRDT at the laboratory of the University Hospital of Liège.
Disciplines :
Immunology & infectious disease
Author, co-author :
SEYNAEVE, Ysaline ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
Heylen, Justine ;  Université de Liège - ULiège > Master sc. pharma., à fin.
FONTAINE, Corentin ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Pool assistant - biologie clinique
MACLOT, Francois  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Unité de laboratoire - biomol virus - Biomoel divers
MEEX, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire bactériologie
Diep, Anh Nguyet  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Simulation en santé publique
Donneau, Anne-Françoise ;  Université de Liège - ULiège > Département des sciences de la santé publique > Biostatistique
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de microbiologie clinique
DESCY, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire mycobactérie
Language :
English
Title :
Evaluation of Two Rapid Antigenic Tests for the Detection of SARS-CoV-2 in Nasopharyngeal Swabs
Publication date :
24 June 2021
Journal title :
Journal of Clinical Medicine
Publisher :
MDPI, Basel, Switzerland
Volume :
10
Issue :
13
Pages :
2774
Peer reviewed :
Peer reviewed
Available on ORBi :
since 26 July 2021

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