[en] Background. Cognitive complaints are gaining more attention as they may represent an early marker of increased risk for AD in individuals without objective decline at standard neuropsychological examination.
Objective. Our aim was to assess whether cognitive complaints in late middle-aged individuals not seeking medical help are related to objective cognitive outcomes known as early markers for AD risk, concomitant affective state, and amyloid-β (Aβ) burden.
Methods. Eighty-seven community-based cognitively normal individuals aged 50-69 years underwent neuropsychological assessment for global cognition, using Preclinical Alzheimer’s Cognitive Composite 5 (PACC5) score, and a more specific episodic memory measure. Affective state was based on self-assessment questionnaires for depression and anxiety. Aβ PET burden was assessed via [18F]Flutemetamol (N=84) and [18F]Florbetapir (N=3) uptake. Cognitive complaints were evaluated using Cognitive Difficulties Scale.
Results. Higher cognitive complaints were significantly associated with lower episodic memory performance and worse affective state. Moreover, higher level of cognitive complaints was related to higher (but still sub-clinical) global Aβ accumulation (at uncorrected significance level). Importantly, all three aspects remained significant when taken together in the same statistical model, indicating that they explained distinct parts of variance.
Conclusion. In healthy Aβ negative late middle-aged individuals, a higher degree of cognitive complaints is associated with lower episodic memory efficiency, more anxiety and depression, as well as, potentially, with higher Aβ burden, suggesting that complaints might signal subtle decline. Future studies should untangle how cognitive complaints in healthy aging populations are related to longitudinal changes in objective cognition and AD biomarker correlates.
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Narbutas, Justinas ; Université de Liège - ULiège > GIGA-CRC In Vivo Imaging
Van Egroo, Maxime; Université de Liège - ULiège > GIGA-CRC In Vivo Imaging
Chylinski, Daphné ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Koshmanova, Ekaterina ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Talwar, Puneet ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Besson, Gabriel ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory
Muto, Vincenzo ; Université de Liège - ULiège > GIGA CRC In vivo Imaging
Schmidt, Christina ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Balteau, Evelyne ; Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.
Phillips, Christophe ; Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.
MAQUET, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.
Bastin, Christine ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Vandewalle, Gilles ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Associations between cognitive complaints, memory performance, mood and amyloid-β accumulation in healthy amyloid negative late-midlife individuals
Publication date :
2021
Journal title :
Journal of Alzheimer's Disease
ISSN :
1387-2877
eISSN :
1875-8908
Volume :
83
Pages :
127-141
Peer reviewed :
Peer reviewed
Name of the research project :
Cognitive Fitness in Aging study ERDF, Radiomed Project
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] WBI - Wallonia-Brussels International [BE] ULiège - Université de Liège [BE] Fondation Pierre et Simone Clerdent [BE] ERDF - European Regional Development Fund [BE] ERC - European Research Council [BE]
Funding number :
Fonds National de la Recherche Scientifique (FRS-FNRS, FRSM 3.4516.11, MEMODYN 30446199, Belgium); Wallonia-Brussels Federation (grant for Concerted Research Actions – grant 17/21-09 SLEEPDEM); SAO-FRA (grant 15018); European Research Council starting grant (CS; ERC-StG 757763)
Funding text :
[18F]Flutemetamol doses were provided and cost covered by GE Healthcare Ltd (Little Chalfont, UK) as part of an investigator sponsored study (ISS290) agreement. This agreement had no influence on the protocol and results of the study reported here
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