Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status
Narbutas, Justinas; Chylinski, Daphné; Van Egroo, Maximeet al.
2021 • In Frontiers in Aging Neuroscience, 13, p. 666181
cognitive performance; cognitive reserve; allostatic load; AD biomarkers; APOE; midlife
Abstract :
[en] Studies exploring the simultaneous influence of several physiological and environmental factors on domain-specific cognition in late middle-age remain scarce. Therefore, our objective was to determine the respective contribution of modifiable risk/protective factors (cognitive reserve and allostatic load) on specific cognitive domains (episodic memory, executive functions, and attention), taking into account non-modifiable factors [sex, age, and genetic risk for Alzheimer’s disease (AD)] and AD-related biomarker amount (amyloid-beta and tau/neuroinflammation) in a healthy late-middle-aged population. One hundred and one healthy participants (59.4 ± 5 years; 68 women) were evaluated for episodic memory, executive and attentional functioning via neuropsychological test battery. Cognitive reserve was determined by the National Adult Reading Test. The allostatic load consisted of measures of lipid metabolism and sympathetic nervous system functioning. The amyloid-beta level was assessed using positron emission tomography in all participants, whereas tau/neuroinflammation positron emission tomography scans and apolipoprotein E genotype were available for 58 participants. Higher cognitive reserve was the main correlate of better cognitive performance across all domains. Moreover, age was negatively associated with attentional functioning, whereas sex was a significant predictor for episodic memory, with women having better performance than men. Finally, our results did not show clear significant associations between performance over any cognitive domain and apolipoprotein E genotype and AD biomarkers. This suggests that domain-specific cognition in late healthy midlife is mainly determined by a combination of modifiable (cognitive reserve) and non-modifiable factors (sex and age) rather than by AD biomarkers and genetic risk for AD.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology Neurosciences & behavior Geriatrics
Author, co-author :
Narbutas, Justinas ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Chylinski, Daphné ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Van Egroo, Maxime; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Koshmanova, Ekaterina ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Besson, Gabriel ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory
Muto, Vincenzo ; Université de Liège - ULiège > GIGA CRC In vivo Imaging
Schmidt, Christina ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Balteau, Evelyne ; Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.
Phillips, Christophe ; Université de Liège - ULiège > GIGA CRC In vivo Im. - Neuroimaging, data acquisi. & proces.
MAQUET, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.
Vandewalle, Gilles ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Sleep and chronobiology
Bastin, Christine ; Université de Liège - ULiège > GIGA CRC In vivo Imaging - Aging & Memory
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status
Cognitive Fitness in Aging study Fonds National de la Recherche Scientifique (FRS-FNRS, FRSM 3.4516.11, EOS Project MEMODYN No. 30446199; Belgium) Wallonia-Brussels Federation (Grant for Concerted Research Actions— SLEEPDEM) European Regional Development Fund (ERDF, Radiomed Project)
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique FWB - Fédération Wallonie-Bruxelles ULiège - Université de Liège Fondation Pierre et Simone Clerdent ERDF - European Regional Development Fund ERC - European Research Council
Funding text :
[18F]Flutemetamol doses were provided and cost covered by GE Healthcare Ltd. (Little Chalfont, United Kingdom) as part of an investigatorsponsored study (ISS290) agreement. The latter agreement had no influence on the protocol and results of the study reported here.
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