Article (Scientific journals)
Une décennie d’avancées dans l’asthme : l’apport des biothérapies.
Schleich, Florence; Frix, Anne-Noëlle; Paulus, Virginie et al.
2020In Revue Médicale de Liège, 75 (5-6), p. 350-355
Peer reviewed
 

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Keywords :
Anti-Asthmatic Agents; Asthma/therapy; Belgium; Biological Therapy; Humans; Quality of Life; Biologicals; Eosinophils; Induced sputum; Type 2 inflammation; Severe asthma
Abstract :
[en] Asthma is a chronic heterogeneous airway disease. There are different asthma inflammatory phenotypes with various responses to treatment and different disease severities. When asthma requires chronic systemic corticosteroids or hospitalizations despite maximal inhaled therapies in asthmatic patients in whom comorbidities have been managed and who are considered as compliant, the pulmonologist may propose biological treatment to reduce exacerbations and the dose of systemic corticosteroids. During the last ten years, the number of biologics for the management of type-2 severe asthma has increased. Anti-IgE monoclonal antibodies (omalizumab) are available for more than ten years and recommended in severe allergic asthma. New biologics are now available to block IL-5 (mepolizumab, reslizumab) or its receptor (benralizumab). These treatments allow a reduction of exacerbations and of the dose of systemic corticosteroids, an improvement in asthma control, in asthma quality of life and for some of them, an increase in lung function. New biologics will soon be available in Belgium for the management of severe asthma. In addition to the improvement of asthma control in severe asthma, biological treatments have improved the understanding of the mechanisms leading to severe asthma.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Schleich, Florence ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Frix, Anne-Noëlle ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
Paulus, Virginie 
Guissard, Françoise 
Sanchez, Carole 
Henket, Monique 
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
French
Title :
Une décennie d’avancées dans l’asthme : l’apport des biothérapies.
Alternative titles :
[en] Asthma : the contribution of biotherapies
Publication date :
2020
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
75
Issue :
5-6
Pages :
350-355
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 February 2021

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