Article (Scientific journals)
Organic wastes as feedstocks for non-conventional yeast-based bioprocesses
Do Thi Hoang Diem; Theron, Chrispian; Fickers, Patrick
2019In Microorganisms, 7 (8)
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Keywords :
Alternative feedstocks; Microbial bioprocesses; Recombinant proteins; Value added products; Waste valorization; Yarrowia lipolytica; Yeast biomass
Abstract :
[en] Non-conventional yeasts are efficient cell factories for the synthesis of value-added compounds such as recombinant proteins, intracellular metabolites, and/or metabolic by-products. Most bioprocess, however, are still designed to use pure, ideal sugars, especially glucose. In the quest for the development of more sustainable processes amid concerns over the future availability of resources for the ever-growing global population, the utilization of organic wastes or industrial by-products as feedstocks to support cell growth is a crucial approach. Indeed, vast amounts of industrial and commercial waste simultaneously represent an environmental burden and an important reservoir for recyclable or reusable material. These alternative feedstocks can provide microbial cell factories with the required metabolic building blocks and energy to synthesize value-added compounds, further representing a potential means of reduction of process costs as well. This review highlights recent strategies in this regard, encompassing knowledge on catabolic pathways and metabolic engineering solutions developed to endow cells with the required metabolic capabilities, and the connection of these to the synthesis of value-added compounds. This review focuses primarily, but not exclusively, on Yarrowia lipolytica as a yeast cell factory, owing to its broad range of naturally metabolizable carbon sources, together with its popularity as a non-conventional yeast. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Disciplines :
Biotechnology
Author, co-author :
Do Thi Hoang Diem ;  Microbial Processes and Interactions, TERRA Teaching and Research Centre, University of Liège-Gembloux AgroBio Tech, Av. de la Faculté, 2B, Gembloux, B-5030, Belgium
Theron, Chrispian ;  Microbial Processes and Interactions, TERRA Teaching and Research Centre, University of Liège-Gembloux AgroBio Tech, Av. de la Faculté, 2B, Gembloux, B-5030, Belgium
Fickers, Patrick ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Language :
English
Title :
Organic wastes as feedstocks for non-conventional yeast-based bioprocesses
Publication date :
2019
Journal title :
Microorganisms
eISSN :
2076-2607
Publisher :
MDPI AG
Volume :
7
Issue :
8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 February 2021

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