Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial

Neyrinck, A.; Rodriguez, J.; Taminiau, Bernard; Amadieu, C.; Herpin, F.; Allaert, F.A.; Cani, P.; Daube, Georges; Bindels, L.; Delzenne, N.

doi:10.1038/s41598-020-80947-1

Article (Scientific journals)

Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial

Neyrinck, A.; Rodriguez, J.; Taminiau, Bernard et al.

2021 • In Scientific Reports, 11, p. 2627

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/256998

DOI
10.1038/s41598-020-80947-1

PubMed
33514774

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Keywords :

synbiotic; middle-aged adult; gastrointestinal discomfort

Abstract :

[en] Several studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a synbiotic approach (co-administration of a probiotic bacteria and a prebiotic dietary fibre) to improve gastrointestinal wellness and inflammatory markers in middle-aged people. Middle-aged subjects were randomized to take synbiotic (Bifidobacterium animalis lactis and fructo-oligosaccharides (FOS)) or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotictreated volunteers while the synbiotic treatment significantly decreased the number of days with abdominal discomfort. Synbiotic treatment had no impact on mood dimensions, quality of life scores or the overall composition of the gut microbiota (16S rRNA gene sequencing of DNA extracted from stool). Importantly, plasma proinflammatory cytokines (interleukin (IL)-6, IL-8, IL-17a and interferongamma (IFNγ)) were significantly lower after 30 days of synbiotic supplementation. This effect appears to be independent of the gut barrier function. This study demonstrates that a combination of B. animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease inflammatory status with improvement of gut disorders in middle-aged people.

Disciplines :

Gastroenterology & hepatology

Author, co-author :

Neyrinck, A.

Rodriguez, J.

Taminiau, Bernard ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires

Amadieu, C.

Herpin, F.

Allaert, F.A.

Cani, P.

Daube, Georges ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires

Bindels, L.

Delzenne, N.

Language :

English

Title :

Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial

Publication date :

2021

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Pages :

2627

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

Nutrigutior

Funders :

Service public de Wallonie. Secrétariat général - SPW-SG

Available on ORBi :

since 17 February 2021

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