Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial
[en] Several studies suggest that microbial alterations (dysbiosis) are intimately linked to chronic
inflammation occurring upon aging. The aim of this study was to investigate the potential interest of a
synbiotic approach (co-administration of a probiotic bacteria and a prebiotic dietary fibre) to improve
gastrointestinal wellness and inflammatory markers in middle-aged people. Middle-aged subjects
were randomized to take synbiotic (Bifidobacterium animalis lactis and fructo-oligosaccharides (FOS))
or placebo for 30 days. Stool frequency and consistency were improved in both placebo and synbiotictreated
volunteers while the synbiotic treatment significantly decreased the number of days with
abdominal discomfort. Synbiotic treatment had no impact on mood dimensions, quality of life scores
or the overall composition of the gut microbiota (16S rRNA gene sequencing of DNA extracted from
stool). Importantly, plasma proinflammatory cytokines (interleukin (IL)-6, IL-8, IL-17a and interferongamma
(IFNγ)) were significantly lower after 30 days of synbiotic supplementation. This effect appears
to be independent of the gut barrier function. This study demonstrates that a combination of B.
animalis lactis and the well-known prebiotic FOS could be a promising synbiotic strategy to decrease
inflammatory status with improvement of gut disorders in middle-aged people.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Neyrinck, A.
Rodriguez, J.
Taminiau, Bernard ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
Amadieu, C.
Herpin, F.
Allaert, F.A.
Cani, P.
Daube, Georges ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
Bindels, L.
Delzenne, N.
Language :
English
Title :
Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial
Publication date :
2021
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
11
Pages :
2627
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Nutrigutior
Funders :
Service public de Wallonie. Secrétariat général - SPW-SG
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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