Unpublished conference/Abstract (Scientific congresses and symposiums)
Association between sleep regulation and neuroimaging-derived myelin markers
Deantoni, Michele; Muto, Vincenzo; Hammad, Grégory et al.
202025th Congress of the European Sleep Research Society ESRS
 

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Keywords :
Myelin; Sleep; REM; NREM; brain maturation
Abstract :
[en] Introduction Sleep plays a crucial role in brain plasticity, and has been suggested to be involved in myelin organization. Here we assessed the association between sleep homeostatic responses and quantitative MRI-derived myelin content in a sample of healthy young men. Methods: 238 male participants (age: 22.12.7) underwent an in-lab protocol to assess homeostatic responses in slow wave and REM sleep through a modulation of prior wakefulness and sleep duration. The protocol encompassed four conditions: a baseline night (BAS, duration adjusted on participant’s sleep-wake schedule), a 12h sleep extension night (EXT) followed by a 4-h nap and an 8-h sleep opportunity night (sleep saturation; SAT) and a 12h recovery night (REC) following 40-hours sleep deprivation. For each night, four sleep parameters were extracted: sleep slow wave activity at the beginning of the night (SWA0), its overnight exponential dissipation rate (tau), and overnight mean theta and beta power per REM epoch. Participants underwent a multiparameter brain MRI protocol at 3T to extract quantitative maps sensitive to different myelin biomarkers. F-contrasts were calculated to assess whether the modularity of sleep parameters across sleep conditions explains variance in myelin biomarkers. Reported statistics are family-wise-error corrected over the entire brain volume (pFWE <.05). Results: Slow wave sleep duration and SWA0 were modulated across all sleep conditions (REC>BAS>EXT>SAT; all p < 0.001), while REM sleep percentage significantly differed only between SAT and the other sleep contexts (F(3,1257)= 13.676743, p<.001). The modulation of NREM SWA0 was associated with myelin content in the medio-temporal lobe, encompassing the bilateral hippocampus and entorhinal cortex (grey and white matter), while the modulation of REM beta power was associated to myelin content in diffuse thalamocortical tracts and overhead cortices. Discussion: Spectral power in sleep-specific frequency bands across sleep homeostasis contexts is associated with myelin content in the hippocampus and surrounding cortices as well as thalamocortical fibers. The hippocampus has been proposed as a key player for temporal coupling of brain oscillations, while thalamocortical fibers myelination may facilitate the cortical response to sleep-dependent diencephalic activity. As myelin stands for conduction velocity, it could facilitate the modulation of brain electrical oscillations, and putatively also the homeostatic response of sleep.
Disciplines :
Neurology
Neurosciences & behavior
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Deantoni, Michele ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging
Hammad, Grégory  ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Berthomier, Christian;  Physip SA, Paris, France
Baillet, Marion ;  Université de Liège - ULiège > GIGA CRC In vivo Imaging
Reyt, Mathilde ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Jaspar, Mathieu ;  Université de Liège - ULiège > Département de Psychologie > Ergonomie et intervention au travail
Meyer, Christelle;  Université de Liège - ULiège > Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab
Vanegroo, Maxime;  Université de Liège - ULiège > Cyclotron Research Center/In Vivo Imaging, Sleep and Chronobiology Lab
Lambot, Eric ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
Chellappa, Sarah Laxhmi ;  Division of Sleep and Circadian Disorders, Boston, MA, United States > Departments of Medicine and Neurology, Brigham and Women's Hospital,
Brandewinder, Marie;  Physip SA, Paris, France
Degueldre, Christian ;  Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
SALMON, Eric  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre de jour interdisciplinaire des troubles de la mémoire
Phillips, Christophe  ;  Université de Liège - ULiège > CRC In vivo Im.-Neuroimaging, data acquisition & processing
Balteau, Evelyne ;  Université de Liège - ULiège > CRC In vivo Im.-Neuroimaging, data acquisition & processing
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie
Dijk, Derk-Jan;  University of Surrey > Faculty of Health and Medical Sciences, > Surrey Sleep Research Centre
Vandewalle, Gilles  ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
MAQUET, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Schmidt, Christina  ;  Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology
More authors (12 more) Less
Language :
English
Title :
Association between sleep regulation and neuroimaging-derived myelin markers
Publication date :
22 September 2020
Event name :
25th Congress of the European Sleep Research Society ESRS
Event date :
from 22-9-2020 to 24-9-2020
Audience :
International
Funders :
WELBIO - Walloon Excellence in Life Sciences and Biotechnology [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ARC of Wallonia-Brussels federation
Fondation Pierre et Simone Clerdent [BE]
FMRE - Fondation Médicale Reine Elisabeth [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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since 08 February 2021

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