Article (Scientific journals)
Joining soft tissues to bone: Insights from modeling and simulations
Tits, Alexandra; Ruffoni, Davide
2021In Bone Reports
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Keywords :
Enthesis; Bone-tendon interface; Modeling; Computer simulations; Fibrocartilage; Bimaterial attachment; Finite element analysis
Abstract :
[en] Entheses are complex multi-tissue regions of the musculoskeletal system serving the challenging task of con-necting highly dissimilar materials such as the compliant tendon to the much stiffer bone, over a very small region. The first aim of this review is to highlight mathematical and computational models that have been developed to investigate the many attachment strategies present at entheses at different length scales. Entheses are also relevant in the medical context due to the high prevalence of orthopedic injuries requiring the reat-tachment of tendons or ligaments to bone, which are associated with a rather poor long-term clinical outcome. The second aim of the review is to report on the computational works analyzing the whole tendon to bone complex as well as targeting orthopedic relevant issues. Modeling approaches have provided important insights on anchoring mechanisms and surgical repair strategies, that would not have been revealed with experiments alone. We intend to demonstrate the necessity of including, in future models, an enriched description of enthesis biomechanical behavior in order to unravel additional mechanical cues underlying the development, the func-tioning and the maintaining of such a complex biological interface as well as to enhance the development of novel biomimetic adhesive, attachment procedures or tissue engineered implants.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Tits, Alexandra ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
Ruffoni, Davide  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
Language :
English
Title :
Joining soft tissues to bone: Insights from modeling and simulations
Publication date :
2021
Journal title :
Bone Reports
eISSN :
2352-1872
Publisher :
Elsevier, Amsterdam, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 January 2021

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