Article (Scientific journals)
Evolution of Drug Interactions With Antiretroviral Medication in People With HIV.
El Moussaoui, Majdouline; Lambert, Iseult; MAES, Nathalie et al.
2020In Open Forum Infectious Diseases, 7 (11), p. 416
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Keywords :
HIV; antiretroviral therapy; drug interactions
Abstract :
[en] BACKGROUND: Polypharmacy and drug interactions are important issues for HIV-infected individuals. The number and nature of those interactions are continuously evolving with the use of new antiretroviral drugs and the aging of HIV-infected individuals. We aimed to analyze this evolution over time. METHODS: This retrospective cohort study was conducted in the University Hospital of Liège (Belgium). Treatments of HIV-infected outpatients attending Liège University Hospital were collected and analyzed in 2012 and 2016. The University of Liverpool HIV drug interactions database was used to determine drug interactions. RESULTS: We included 1038 patients in 2016, of whom 78% had 1 comedication. Polypharmacy was seen in 20% of the cohort. Four percent of the patients presented red flag interactions, and 38% had orange flag interactions. Nonantiretroviral (non-ARV) therapeutic classes involved in drug interactions were mostly cardiovascular and central nervous system drugs. They were followed by hormone drugs and dietary supplements for orange flag interactions. Two factors significantly contributed to both red and orange flag interactions: the number of non-ARV comedications and protease inhibitor-based ARV regimens. The proportion of patients with red or orange flag interactions remained stable from 2012 to 2016. CONCLUSIONS: This study highlights the persistence of an alarming number of contraindicated drug interactions and a high prevalence of potential drug interactions over time. Identification, prevention, and management of drug interactions remain a key priority in HIV care.
Disciplines :
Immunology & infectious disease
Author, co-author :
El Moussaoui, Majdouline  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
Lambert, Iseult ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
MAES, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
SAUVAGE, Anne-Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
FRIPPIAT, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
MEURIS, Christelle ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
UURLINGS, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
LECOMTE, Marianne ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
LEONARD, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
Fombellida, Karine;  Centre Hospitalier Universitaire de Liège - CHU > Médecine interne > Maladies infectieuses - Médecine interne générale
VAIRA, Dolorès ;  Université de Liège - ULiège > AIDS Reference Laboratory
Vercheval, Christelle ;  Centre Hospitalier Universitaire de Liège - CHU > Pharmacie clinique
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopath. - Maladies infect. et médec. interne gén.
Darcis, Gilles ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine Interne > Maladies infectieuses - Médecine interne générale
More authors (4 more) Less
Language :
English
Title :
Evolution of Drug Interactions With Antiretroviral Medication in People With HIV.
Publication date :
2020
Journal title :
Open Forum Infectious Diseases
eISSN :
2328-8957
Publisher :
Oxford University Press, Cary, United States - North Carolina
Volume :
7
Issue :
11
Pages :
ofaa416
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Available on ORBi :
since 06 January 2021

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