[en] Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-β-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.
Disciplines :
Microbiology
Author, co-author :
Luzzaro, F.; Laboratorio di Microbiologia, Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy
Docquier, Jean-Denis ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'ingénierie des protéines
Colinon, C.; Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy
Endimiani, A.; Laboratorio di Microbiologia, Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy
Lombardi, G.; Laboratorio di Microbiologia, Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy
Amicosante, G.; Dipto. di Sci. e Tecnol. Biomediche, Università di L'Aquila, I-67100 L'Aquila, Italy
Rossolini, G. M.; Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy
Toniolo, A.; Laboratorio di Microbiologia, Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy, Laboratorio di Microbiologia, Ospedale di Circolo, Università dell'Insubria, Viale Borri 57, 21100 Varese, Italy
Language :
English
Title :
Emergence in Klebsiella pneumoniae and Enterobacter cloacae Clinical Isolates of the VIM-4 Metallo-β-Lactamase Encoded by a Conjugative Plasmid
Publication date :
2004
Journal title :
Antimicrobial Agents and Chemotherapy
ISSN :
0066-4804
eISSN :
1098-6596
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
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