Poster (Scientific congresses and symposiums)
Relationship between quality of life and disordered physiology and cytology in asthma : a retrospective study from a secondary care center
Louis, Gilles; Pétré, Benoît; SCHLEICH, FLorence et al.
2020Virtual ERS International Congress
 

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Keywords :
asthma; quality of life; inflammation
Abstract :
[en] Introduction: Asthma related quality of life has become an important outcome in the assessment of a patient alongside classical objective physiological and inflammatory parameters. Methods: We conducted a retrospective study in a large population of asthmatics recruited from a University secondary care center between 2010 and 2019 (N= 1337). Patients completed asthma quality of life questionnaire (AQLQ) and underwent sputum induction. A disease severity classification was determined by the combination of the alteration of physiological and cytological variables. Group 1 (n=304) included mild asthmatics with FEV1 > 80 % of predicated values, sputum eosinophils <3% and sputum neutrophils < 76%. Group 2 (n=81) included moderate asthmatics with FEV1 between 60% and 80% and sputum eosinophils between 3% and 20% or sputum neutrophils between 76% and 90%. Group 3 (n=72) included severe asthmatics with FEV1 <60% and sputum eosinophils > 20% or sputum neutrophils > 90%. Results: For the whole cohort, AQLQ reached on average 4,5 ranging from 1,07 to 7. AQLQ was correlated with FEV1 (rs=0,33 ; p <0,001) and with sputum eosinophils (rs=-0,14 ; p< 0,001) but not with sputum neutrophils (rs=-0,001 ; p = 0,76). There was a progressive and significant decline in mean AQLQ from group 1 to group 3. Mean (± SEM) AQLQ was 4,8 (±0,07), 4 (± 0,14) and 3,5 (± 0,13) in group 1, 2 and 3 respectively. Conclusion: In our retrospective study, asthma related quality of life deteriorates as airway obstruction and sputum eosinophils increase. Because of its impact on quality of life, it seems essential to consider the eosinophilic inflammatory component in asthma management.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Louis, Gilles  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques
Pétré, Benoît  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Education thérap. du patient au serv. des soins int.
SCHLEICH, FLorence ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
HENKET, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique de l'asthme
PAULUS, Virginie ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique de l'asthme
GUISSARD, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique de l'asthme
LOUIS, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
Guillaume, Michèle ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie nutritionnelle
Language :
English
Title :
Relationship between quality of life and disordered physiology and cytology in asthma : a retrospective study from a secondary care center
Publication date :
2020
Event name :
Virtual ERS International Congress
Event date :
du 7 septembre 2020 au 9 septembre 2020
Audience :
International
Available on ORBi :
since 12 October 2020

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