Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases.

[en] Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade that culminates in cellular apoptosis. Despite the CD95 receptor does not exhibit any kinase activity by itself, phosphorylation/dephosphorylation events seem important to regulate many aspects of CD95-mediated apoptosis. Here, we try to highlight particularly the importance of protein phosphatases in the modulation of the CD95 system.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Gloire, Geoffrey ; Université de Liège - ULiège > GIGA-R : Virologie - Immunologie

Charlier, Edith ; Université de Liège - ULiège > GIGA-R : Virologie - Immunologie

Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - GIGA-Research

Language :

English

Title :

Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases.

Publication date :

2008

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Elsevier Science, Oxford, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 October 2009

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