Article (Scientific journals)
Parathormone, bone alkaline phosphatase and 25-hydroxyvitamin D status in a large cohort of 1200 children and teenagers.
LADANG, Aurélie; ROUSSELLE, Olivier; Huyghebaert, Loreen et al.
2020In Acta Clinica Belgica, p. 1-6
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Keywords :
Parathyroid hormone; bone alkaline phosphatase; children; pediatric reference range; vitamin D
Abstract :
[en] OBJECTIVES: 25-Hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone alkaline phosphatase (BALP) are biomarkers of calcium/phosphate metabolism and bone turnover. Although vitamin D deficiency is a well-known cause of secondary hyperparathyroidism, few studies have considered vitamin D status when establishing reference ranges. In this study, we report PTH levels according to the vitamin D status and BALP levels in a large cohort of 1200 children. Additionally, we provide PTH pediatric reference values according to 25(OH)D status as well as BALP pediatric reference ranges. METHODS: Serum samples from 1200 children (equally distributed from 5 months to 20 years old) who underwent blood sampling for allergy exploration were used to quantify 25(OH)D, PTH and BALP. RESULTS: The percentage of vitamin D deficient children (<20 ng/ml) progressively increased during childhood starting from 7% in the 0 to 2 year-old subgroup to a mean of at least 50% among teenagers. PTH levels inversely mirrored 25(OH)D concentrations for all age and gender subgroups, and 25(OH)D deficient subgroups presented higher PTH levels than their non-deficient counterparts. In the non-deficient 25(OH)D population, PTH levels were the highest at 11 years old for girls and 14 years old for boys. BALP results were slightly increased during childhood and showed a constant decrease during teenage years starting from 12 years old for girls and 14 years old for boys. CONCLUSION: Our results highlight the inverse relationship between PTH and 25(OH)D in children and the need for a well characterized 25(OH)D population to establish pediatric reference ranges for PTH.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
LADANG, Aurélie  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire endocrinologie
ROUSSELLE, Olivier ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire endocrinologie
Huyghebaert, Loreen ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire techniques séparatives et stress oxydant
BEKAERT, Anne-Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Bone and cartilage markers laboratory
KOVACS, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Bone and cartilage markers laboratory
Le Goff, Caroline  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Parathormone, bone alkaline phosphatase and 25-hydroxyvitamin D status in a large cohort of 1200 children and teenagers.
Publication date :
May 2020
Journal title :
Acta Clinica Belgica
ISSN :
1784-3286
eISSN :
2295-3337
Publisher :
Taylor and Francis, Abingdon, United Kingdom
Pages :
1-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 July 2020

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